Skip to main content
SpringerLink
Log in
Book cover

Diagnosis of Musculoskeletal Tumors and Tumor-like Conditions pp 237–239Cite as

Chemotherapy of Ewing Sarcoma

  • Chapter
  • First Online:

  • 1170 Accesses

Abstract

Ewing sarcoma (ES) shares with osteosarcoma similarities in the strategy of treatment.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. ESMO/European Sarcoma Network Working Group. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012;23(Suppl 7):vii100–9.

    Google Scholar 

  2. Grier HE, Krailo MD, Tarbell NJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003;348(8):694–701.

    Article  CAS  Google Scholar 

  3. Cotterill SJ, Ahrens S, Paulussen M, et al. Prognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing’s Sarcoma Study Group. J Clin Oncol. 2000;18:3108–14.

    Article  CAS  Google Scholar 

  4. Bacci G, Ferrari S, Bertoni F, et al. Prognostic factors in nonmetastatic Ewing’s sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli. J Clin Oncol. 2000;18:4–11.

    Article  CAS  Google Scholar 

  5. Granowetter L, Womer R, Devidas M, et al. Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children’s Oncology Group Study. J Clin Oncol. 2009;27(15):2536–41.

    Article  CAS  Google Scholar 

  6. Womer RB, West DC, Krailo MD, et al. Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children’s Oncology Group. J Clin Oncol. 2012;30(33):4148–54.

    Article  CAS  Google Scholar 

  7. Ferrari S, Sundby Hall K, Luksch R, et al. Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients. Results of the Italian Sarcoma Group/Scandinavian Sarcoma Group III protocol. Ann Oncol. 2011;22(5):1221–7.

    Article  CAS  Google Scholar 

  8. Whelan J, Le Deley MC, Dirksen U, et al. Efficacy of busulfan-melphalan high dose chemotherapy consolidation (BuMel) in localized high-risk Ewing sarcoma (ES): results of EURO-EWING 99-R2 randomized trial (EE99R2Loc). J Clin Oncol. 2016;34(15_Suppl):11000.

    Article  Google Scholar 

  9. Cangir A, Vietti TJ, Gehan EA, et al. Ewing’s sarcoma metastatic at diagnosis. Results and comparisons of two intergroup Ewing’s sarcoma studies. Cancer. 1990;66:887–93.

    Article  CAS  Google Scholar 

  10. Kolb EA, Kushner BH, Gorlick R, et al. Long-term event-free survival after intensive chemotherapy for Ewing’s family of tumors in children and young adults. J Clin Oncol. 2003;21(18):3423–30.

    Article  CAS  Google Scholar 

  11. Luksch R, Tienghi A, Hall KS, et al. Primary metastatic Ewing’s family tumors: results of the Italian Sarcoma Group and Scandinavian Sarcoma Group ISG/SSG IV Study including myeloablative chemotherapy and total-lung irradiation. Ann Oncol. 2012;23(11):2970–6.

    Article  CAS  Google Scholar 

  12. Ladenstein R, Pötschger U, Le Deley MC, et al. Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial. J Clin Oncol. 2010;28(20):3284–91.

    Article  CAS  Google Scholar 

  13. Dirksen U, Le Deley MC, Brennan B, et al. Efficacy of busulfan-melphalan high dose chemotherapy consolidation (BuMel) compared to conventional chemotherapy combined with lung irradiation in ewing sarcoma (ES) with primary lung metastases: Results of EURO-EWING 99-R2pulm randomized trial (EE99R2pul). J Clin Oncol. 2016;34(15_Suppl):11001.

    Article  Google Scholar 

  14. Bacci G, Longhi A, Ferrari S, et al. Pattern of relapse in 290 patients with nonmetastatic Ewing’s sarcoma family tumors treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999. Eur J Surg Oncol. 2006;32(9):974–9.

    Article  CAS  Google Scholar 

  15. Briccoli A, Rocca M, Ferrari S, Mercuri M, Ferrari C, Bacci G. Surgery for lung metastases in Ewing’s sarcoma of bone. Eur J Surg Oncol. 2004;30(1):63–7.

    Article  CAS  Google Scholar 

  16. Hunold A, Weddeling N, Paulussen M, Ranft A, Liebscher C, Jürgens H. Topotecan and cyclophosphamide in patients with refractory or relapsed Ewing tumors. Pediatr Blood Cancer. 2006;47(6):795–800.

    Article  Google Scholar 

  17. Wagner LM, McAllister N, Goldsby RE, et al. Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma. Pediatr Blood Cancer. 2007;48(2):132–9.

    Article  Google Scholar 

  18. Palmerini E, Jones RL, Setola E, et al. Irinotecan and temozolomide in recurrent Ewing sarcoma: an analysis in 51 adult and pediatric patients. Acta Oncol. 2018;13:1–7.

    Google Scholar 

  19. Ferrari S, del Prever AB, Palmerini E, et al. Response to high-dose ifosfamide in patients with advanced/recurrent Ewing sarcoma. Pediatr Blood Cancer. 2009;52(5):581–4.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chemotherapy Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Stefano Ferrari & Emanuela Palmerini

  2. Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy

    Emanuela Palmerini

Authors
  1. Stefano Ferrari
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Emanuela Palmerini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Emanuela Palmerini .

Editor information

Editors and Affiliations

  1. I.S.G. Italian Sarcoma Group, Bologna, Italy

    Piero Picci

  2. IIIrd Clinic of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy

    Marco Manfrini

  3. Istituto Ortopedico Rizzoli, Bologna, Italy

    Davide Maria Donati

  4. Department of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Marco Gambarotti

  5. Department of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Alberto Righi

  6. Istituto Rizzoli, Bologna, Italy

    Daniel Vanel

  7. Department of Medicine, University of Padua School of Medicine, Padua, Italy

    Angelo Paolo Dei Tos

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ferrari, S., Palmerini, E. (2020). Chemotherapy of Ewing Sarcoma. In: Picci, P., et al. Diagnosis of Musculoskeletal Tumors and Tumor-like Conditions. Springer, Cham. https://doi.org/10.1007/978-3-030-29676-6_41

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-29676-6_41

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-29675-9

  • Online ISBN: 978-3-030-29676-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation