Abstract
Endometrial hyperplasia (EH) represents a spectrum of irregular morphological alterations, whereby abnormal proliferation of the endometrial gland results in increased thickness of endometrial tissue with alterations of glandular architecture and in an increase in gland-to-stroma ratio when compared to endometrium from the proliferative phase of the cycle. There are two different systems to classify endometrial hyperplasia, the World Health Organization (WHO) schema and the endometrial intraepithelial neoplasia (EIN). Endometrial hyperplasia’s risk factors are the same as those of endometrial cancer type1. Endometrial hyperplasia is often suspected in women with abnormal uterine bleeding and diagnosis is performed by transvaginal ultrasonography and hysteroscopy. The confirmation of diagnosis requires histological analysis of endometrial tissue by hysteroscopy.
Based on our experience and the nomenclature used by Italian authors, we developed a classification of hysteroscopic images based on the degree of hysteroscopic suspicion.
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References
Ellenson LH, Ronnett BM, Kurman RJ. Precursor lesions of endometrial carcinoma. In: Kurman RJ, Ellenson LH, Ronnett BM, editors. Blaustein’s pathology of the female genital tract. Boston, MA: Springer; 2011. p. 359–92.
Kurman R, Carcangiu M, Herrington C, Young R. World Health Organisation classification of tumors of female reproductive organs. 4th ed. Lyon, France: International Agency for Research on Cancer (IARC) Press; 2014.
Silverberg SG. Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. Mod Pathol. 2000;13:309–27.
Murali R, Soslow RA, Weigelt B. Classification of endometrial carcinoma: more than two types. Lancet Oncol. 2014;15:e268–78.
Creasman WT, Odicino F, Maisonneuve P, Quinn MA, Beller U, Benedet JL, Heintz APM, Ngan HYS, Pecorelli S. Carcinoma of the corpus uteri. FIGO 26th annual report on the results of treatment in gynecological cancer. Int J Gynaecol Obstet. 2006;95:S105–43.
Abu-Rustum NR, Zhou Q, Gomez JD, Alektiar KM, Hensley ML, Soslow RA, Levine DA, Chi DS, Barakat RR, Iasonos A. A nomogram for predicting overall survival of women with endometrial cancer following primary therapy: toward improving individualized cancer care. Gynecol Oncol. 2010;116:399–403.
Matias-Guiu X, Prat J. Molecular pathology of endometrial carcinoma. Histopathology. 2013;62:111–23.
Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long-term study of ‘untreated’ hyperplasia in 170 patients. Cancer. 1985;56:403–12.
Dotto J. Early endometrial cancer detection and its precursors in high-risk patients using cytology and microhysteroscopy. Doctoral thesis, Facultad de Medicina, University of Buenos Aires, Argentina; 1989.
Arrighi A, Testa R, Orman S, et al. La pesquisa del carcinoma endometrial. Rev Soc Obstet Gynecol. 1994;73:3–7.
Scarselli G, Mencaglia L, Tantini C, et al. Attualita e propettive di una nuovatecnicaendoscopicanellaroutineginecologica: La microcolpohisteroscopia. Patol Clin Obstet Ginecol. 1983;11:343–74.
Hamou J. Aspects microhysteroscopiques. In: Hamou J, editor. Hysteroscopieet Microcolpohysteroscopie. Atlas et Traite. Paris: Appleton & Lange; 1984. p. 99.
Dotto J, Ghinelli C, Novelli J, et al. Correlación citohistopatológica en patología endometrial. Rev Soc Obstet Gyneco. 1980;159:237.
Dotto J, Lema B, Dotto J Jr, Hamou J. Classification of microhysteroscopic images and their correlation with histologic diagnoses. J Am Gynecol Laparosc. 2003;10(2):233–46.
Hamou JE. Mycrohysteroscopie, une novelle technique en endoscopie, ses applications. Acta Endosc. 1980;10:415–22.
Kurman R, Kaminsky P, Norris H. The behavior of endometrial hyperplasia. A long term study of untreated hyperplasia in 170 patients. Cancer. 1985;56:403–12.
Mencaglia L, Tantini C, Pappalardo S, et al. Classificazzionee datiepidemiologicisulleiperplasiaendometriali. Presented at the Congresso Nazionale de Endocrinologia Ginecologia, Madonna di Campligio, Italy, March 18–25; 1984.
Mencaglia L, Scarselli G. Etatsprecancereux et cancereux de l’endometre. In: Hamou J, editor. Hysteroscopie et Microcolpohysteroscopie. Atlas et Traite. Palermo, Italy: Cofese; 1984. p. 145–63.
Mencaglia L, Scarselli G, Tantini C, et al. Programma di screening per il carcinoma dellèndometrio. Bol Assoc Ital Endosc Ginecol. 1985;11:123–6.
Mencaglia L, Perino A, Hamou J. Hysteroscopy in perimenopausal and postmenopausal women with abnormal uterine bleeding. J Reprod Med. 1987;32:577–82.
Bergeron C, Nogales FF, Masseroli M, Abeler V, Duvillard P, Müller-Holzner E, Pickartz H, Wells M. A multicentric European study testing the reproducibility of the WHO classification of endometrial hyperplasia with a proposal of a simplified working classification for biopsy and curettage specimens. Am J Surg Pathol. 1999;23:1102–8.
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Dotto, J.E., Bigozzi, M.A. (2020). Endometrial Hyperplasia. In: Tinelli, A., Alonso Pacheco, L., Haimovich, S. (eds) Atlas of Hysteroscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-29466-3_14
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DOI: https://doi.org/10.1007/978-3-030-29466-3_14
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