Hypoparathyroidism in Children
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Hypoparathyroidism is a very uncommon endocrine disorder in children. In contrast to adults, in whom most cases of hypoparathyroidism are due to neck surgery, in children and adolescents, hypoparathyroidism is typically due to a genetic etiology. Identifying the genetic basis for hypoparathyroidism has important implications for both the patient and their family and can guide treatment as well as facilitate screening for anticipated comorbidities. Treatment and management can be challenging, especially in infancy. It is important to monitor treatment of hypoparathyroidism regularly in order to reduce the risk of developing nephrocalcinosis and nephrolithiasis. For at least some children with hypoparathyroidism who do not optimally respond to conventional therapy, PTH and PTH analogs represent an alternative treatment option.
KeywordsHypoparathyroidism Pediatrics Parathyroid hormone Etiologies Treatment
Conflict of Interest
Dr. Michael A. Levine has served as an advisory board member, research investigator, and consultant for Shire/Takeda.
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