Abstract
Proton pump inhibitor (PPI)-induced hypocalcemia is a serious adverse effect of a widely prescribed medication, especially for patients with hypoparathyroidism. We present the case of PPI-associated hypocalcemia in a patient with postsurgical hypoparathyroidism. A 58-year-old woman with a history of papillary thyroid cancer status post total thyroidectomy 20 years ago with postsurgical hypothyroidism and hypoparathyroidism with hypercalciuria on stable dosages of calcitriol 0.5 mcg once a day, dietary calcium, and chlorthalidone presented with severe, symptomatic hypocalcemia 4 days after starting lansoprazole. This condition resolved following cessation of PPI therapy and the replenishment of calcium stores. Proton pump inhibitor therapy can induce severe, symptomatic hypocalcemia in patients with chronic hypoparathyroidism.
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Vallejo, F., Sum, M. (2020). Acute Hypocalcemia from Proton Pump Inhibitor Use. In: Cusano, N. (eds) Hypoparathyroidism. Springer, Cham. https://doi.org/10.1007/978-3-030-29433-5_2
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DOI: https://doi.org/10.1007/978-3-030-29433-5_2
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