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Hypoparathyroidism in Pregnancy

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Hypoparathyroidism

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Abstract

Hypoparathyroidism during pregnancy requires careful review and follow-up to avoid maternal and fetal complications including fetal losses. Pregnancy is associated with physiologic changes in the calcium-regulating hormones which include a rise in calcitriol levels, with increased calcium absorption from the bowel, as well as an increase in the renal calcium filtered load. Parathyroid hormone related peptide (PTHrP) production is increased, and the source is both the placenta and the breasts. There is variation in the response to these physiologic changes during pregnancy, and women require close monitoring to ensure that serum calcium is maintained in the low-normal reference range. Calcium supplements are safe in pregnancy, as is the use of calcitriol and cholecalciferol. The safety of PTH has not been evaluated during pregnancy. The use of hydrochlorothiazide is not recommended during pregnancy. Close monitoring by a multidisciplinary team including primary care, endocrinologist, pediatrician, and obstetrician is necessary for optimal outcomes for both the mother and the baby.

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Conflict of Interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. McMaster University, Hamilton, ON, Canada

    Yousef Alalawi, Hajar Abu Alrob & Aliya Khan

  2. Bone Research and Education Centre, Oakville, ON, Canada

    Iman M’Hiri

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  1. Yousef Alalawi
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  2. Iman M’Hiri
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  4. Aliya Khan
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Correspondence to Aliya Khan .

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Editors and Affiliations

  1. Department of Medicine, Division of Endocrinology, Northwell Health/Lenox Hill Hospital, New York, NY, USA

    Natalie E. Cusano

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Alalawi, Y., M’Hiri, I., Alrob, H.A., Khan, A. (2020). Hypoparathyroidism in Pregnancy. In: Cusano, N. (eds) Hypoparathyroidism. Springer, Cham. https://doi.org/10.1007/978-3-030-29433-5_15

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  • DOI: https://doi.org/10.1007/978-3-030-29433-5_15

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  • Print ISBN: 978-3-030-29432-8

  • Online ISBN: 978-3-030-29433-5

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