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Hypoparathyroidism and Quality of Life

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Hypoparathyroidism
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Abstract

Patients with hypoparathyroidism often have many complaints that suggest poor quality of life (QOL). There is a large intra- and interindividual variability in these impairments, which is not clearly explained by the underlying biochemical differences. Formal studies of QOL in this disease are becoming available but do suffer from the lack of disease-specific instruments. Such instruments would be helpful for quantifying the subjective experiences that patients have when on conventional therapy as well as in response to PTH and its analogs. Further studies are also needed to understand the mechanisms of QOL deficits and their relationship to biochemical control.

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References

  1. Mannstadt M, et al. Efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study. Lancet Diabetes Endocrinol. 2013;1(4):275–83.

    Article  CAS  Google Scholar 

  2. Buttner M, Musholt TJ, Singer S. Quality of life in patients with hypoparathyroidism receiving standard treatment: a systematic review. Endocrine. 2017;58(1):14–20.

    Article  Google Scholar 

  3. Shoback D. Clinical practice. Hypoparathyroidism. N Engl J Med. 2008;359(4):391–403.

    Article  CAS  Google Scholar 

  4. Shoback DM, et al. Presentation of hypoparathyroidism: etiologies and clinical features. J Clin Endocrinol Metab. 2016;101(6):2300–12.

    Article  CAS  Google Scholar 

  5. Santonati A, et al. PTH(1-34) for surgical hypoparathyroidism: a prospective, open-label investigation of efficacy and quality of life. J Clin Endocrinol Metab. 2015;100(9):3590–7.

    Article  CAS  Google Scholar 

  6. Arlt W, et al. Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D. Eur J Endocrinol. 2002;146(2):215–22.

    Article  CAS  Google Scholar 

  7. Sikjaer T, et al. Concurrent hypoparathyroidism is associated with impaired physical function and quality of life in hypothyroidism. J Bone Miner Res. 2016;31(7):1440–8.

    Article  Google Scholar 

  8. Cho NL, et al. Surgeons and patients disagree on the potential consequences from hypoparathyroidism. Endocr Pract. 2014;20(5):427–46.

    Article  Google Scholar 

  9. Underbjerg L, et al. Postsurgical hypoparathyroidism – risk of fractures, psychiatric diseases, cancer, cataract, and infections. J Bone Miner Res. 2014;29(11):2504–10.

    Article  Google Scholar 

  10. Underbjerg L, et al. The epidemiology of nonsurgical hypoparathyroidism in Denmark: a Nationwide Case Finding Study. J Bone Miner Res. 2015;30(9):1738–44.

    Article  CAS  Google Scholar 

  11. Astor MC, et al. Epidemiology and health-related quality of life in hypoparathyroidism in Norway. J Clin Endocrinol Metab. 2016;101(8):3045–53.

    Article  CAS  Google Scholar 

  12. Cusano NE, et al. PTH(1-84) is associated with improved quality of life in hypoparathyroidism through 5 years of therapy. J Clin Endocrinol Metab. 2014;99(10):3694–9.

    Article  CAS  Google Scholar 

  13. Cusano NE, et al. The effect of PTH(1-84) on quality of life in hypoparathyroidism. J Clin Endocrinol Metab. 2013;98(6):2356–61.

    Article  CAS  Google Scholar 

  14. Palermo A, et al. PTH(1-34) for surgical hypoparathyroidism: a 2-year prospective, open-label investigation of efficacy and quality of life. J Clin Endocrinol Metab. 2018;103(1):271–80.

    Article  Google Scholar 

  15. Sikjaer T, et al. Effects of PTH(1-84) therapy on muscle function and quality of life in hypoparathyroidism: results from a randomized controlled trial. Osteoporos Int. 2014;25(6):1717–26.

    Article  CAS  Google Scholar 

  16. Vokes TJ, et al. Recombinant human parathyroid hormone effect on health-related quality of life in adults with chronic hypoparathyroidism. J Clin Endocrinol Metab. 2018;103(2):722–31.

    Article  Google Scholar 

  17. Winer KK. Does PTH replacement therapy improve quality of life in patients with chronic hypoparathyroidism? J Clin Endocrinol Metab. 2018;103(7):2752–5.

    Article  Google Scholar 

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Vokes, T. (2020). Hypoparathyroidism and Quality of Life. In: Cusano, N. (eds) Hypoparathyroidism. Springer, Cham. https://doi.org/10.1007/978-3-030-29433-5_13

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  • DOI: https://doi.org/10.1007/978-3-030-29433-5_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-29432-8

  • Online ISBN: 978-3-030-29433-5

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