Lung Cancer Receptors and Targeting Strategies

  • Uday Koli
  • Anomitra Dey
  • P. Nagendra
  • Padma V. Devarajan
  • Ratnesh JainEmail author
  • Prajakta DandekarEmail author
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 39)


Lung cancer still remains the leading cause of cancer-related deaths worldwide. Till now, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) have effectively responded to conventional therapy. However, because of cancer nature and subsequent side effects of conventional therapy, inventing novel drug targets for lung cancer therapies has become essential. The disease management recently has seen a paradigm shift with the advent of next-generation sequencing, which has extensively affected the disease prognosis and hence led to newer targeted therapies. Receptors particularly have played an important role as molecular targets and hence presented new opportunities for intracellular targeting of drug delivery systems. Such approach for therapy not only improves the efficacy of the drug but also reduces the overall systemic cytotoxicity. This chapter extensively focuses on such receptors targeted for lung cancer therapy. Further, the role of receptors like epidermal growth factor receptor (EGFR), c-MET, and vascular endothelial growth factor (VEGF) has been discussed with respect to their appropriate ligand(s) binding and developed nanocarrier system for targeting. In addition, this chapter presents the current status of clinical outcomes of conventional drugs in targeting these receptors and thus improving the overall survival rate in patients suffering from this dreaded disease.


Lung cancer epidermal growth factor receptor (EGFR) ligand targeting c-MET receptor vascular endothelial growth factor receptor 





Anaplastic lymphoma kinase




Antibody-mediated cellular cytotoxicity


Adenosine triphosphate


A disintegrin and metalloproteinase




Confirmed response rate


Epidermal growth factor






Epidermal growth factor receptor


Growth factor receptor-bound protein 2


Hypoxia-activated prodrugs


Hypoxia inducible factor-1α


Hepatocyte growth factor


Hepatocyte growth factor receptor


Heparin-binding EGF


Monoclonal antibodies


Mitogen-activated protein kinase


Non-small cell lung cancer




Objective response rate


Phosphatidylinositol 3′-kinase


Phospholipase C


Phospholipase C-γ




Receptor tyrosine kinases


Squamous cell carcinomas


Small cell lung cancer


Signal transducers and activators of transcription


Structure activity relationship


Single chain variable fragment


Transforming growth factor alpha


Tyrosine kinase inhibitors


Transforming growth factor beta 1


Tumor necrosis factor alpha


Vascular endothelial growth factor


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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  1. 1.Department of Pharmaceutical Sciences &TechnologyInstitute of Chemical Technology, MatungaMumbaiIndia
  2. 2.Department of Pharmaceutical SciencesInsitute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence, Government of MaharashtraMumbaiIndia
  3. 3.Department of Chemical EngineeringInstitute of Chemical Technology, MatungaMumbaiIndia

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