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Cancer of Reproductive System: Receptors and Targeting Strategies

  • Manish Gore
  • Amita Puranik
  • Abhishek Indurkar
  • Bismita Sonowal
  • Padma V. Devarajan
  • Ratnesh JainEmail author
  • Prajakta DandekarEmail author
Chapter
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 39)

Abstract

Carcinogenesis in the different organs of the reproductive system, particularly, prostate, ovarian, and cervical tissues, involves aberrant expression of various physiological receptors belonging to different superfamilies. This chapter provides insights into the physiological receptors that are associated with the genesis, progression, metastasis, management, as well as the prognosis of the cancers of the male and female reproductive systems. It also highlights the structural and binding characteristics of the highly predominant receptors, namely, androgen, estrogen, progesterone, and gonadotropin-releasing hormone (GnRH) receptors, which are overexpressed in these cancers and discusses various strategies to target them.

Keywords

Reproductive Cancers Prostate Ovarian Cervical Receptors Structure Binding Target 

Abbreviations

5-Α DHT

5Α-di-hydro testosterone

AD

Adenovirus

ADC

Antibody–drug conjugates

AIs

Aromatase inhibitors

ARE

Androgen response elements

BPH

Benign prostate hyperplasia

CDK

Cyclin-dependent kinase

CNS

Central nervous system

CRPC

Castrate-resistant prostate cancer

DBD

DNA-binding domain

DOX

Doxorubicin

E2

Estradiol

EGF

Epidermal growth factor

EGFR

Epidermal growth factor receptor

EOC

Endometrial ovarian cancer

ER

Estrogen receptor

ERE

Estrogen response elements

FSH

Follicle-stimulating hormone

FSHR

Follicle-stimulating hormone receptor

GLU

Glutamate

GNRH

Gonadotropin-releasing hormone

GNRHR

Gonadotropin-releasing hormone receptor

GPCR

G-protein-coupled receptor

GPER

G-protein estrogen receptor

HER-2

Human epidermal growth factor receptor-2

HPG

Hypothalamic–pituitary gonadal (axis)

HPV

Human papilloma virus

HRE

Hormone response elements

HSP

Heat shock proteins

i.m.

Intramuscular

LBD

Ligand-binding domain

LBP

Ligand-binding pocket

LH

Luteinizing hormone

LHR

Luteinizing hormone receptor

mAbs

Monoclonal antibodies

MCRPC

Metastatic castrate-resistant prostate cancer

NLS

Nuclear localization signal

NTD

N-terminal transcription regulational domain

P4

Progesterone

PR

Progesterone receptor

PRB

Retinoblastoma protein

PRE

Progesterone response elements

PSA

Prostate-specific antigen

PSGR

Prostate-specific G-protein-coupled receptor

PSMA

Prostate-specific membrane antigen

PSMAA

Prostate-specific membrane aptamers

RES

Reticulo-endothelial system

RP2D

Recommended phase 2 dose

s.c.

Subcutaneous

SAR

Structure–activity relationships

SARM

Selective androgen receptor modulators

SCID

Severe combined immunodeficiency

SERM

Selective estrogen receptor modulators

SMA

Styrene–maleic scid

SMA-RAL

SMA-encapsulated raloxifene

SPRM

Selective progesterone receptor modulators

TMD

Transmembrane domain

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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Manish Gore
    • 1
  • Amita Puranik
    • 3
  • Abhishek Indurkar
    • 1
  • Bismita Sonowal
    • 1
  • Padma V. Devarajan
    • 2
  • Ratnesh Jain
    • 3
    Email author
  • Prajakta Dandekar
    • 2
    Email author
  1. 1.Department of Pharmaceutical Sciences & TechnologyInstitute of Chemical TechnologyMumbaiIndia
  2. 2.Department of Pharmaceutical SciencesInsitute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence, Government of MaharashtraMumbaiIndia
  3. 3.Department of Chemical EngineeringInstitute of Chemical TechnologyMumbaiIndia

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