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Data for HIPEC in Colorectal Cancer (T4 Lesions and Metastases)

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Cancer Regional Therapy

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Abstract

Peritoneal carcinomatosis is a common progression of colorectal cancer with poor prognosis for many patients. Though the advent of modern chemotherapy and biologic treatments has resulted in improved survival for patients with advanced colorectal cancer, patients with peritoneal carcinomatosis have shown worse response to systemic chemotherapy and improvement in their overall and disease-free survival lags behind those with liver and lung metastases. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal cancer represent an important regional approach adjuvant therapy. Though few randomized studies exist, case report and case-control studies continue to demonstrate better than expected survival in select patients with peritoneal carcinomatosis from colorectal cancer when compared to historical controls. Though morbidity and mortality of cytoreductive surgery and HIPEC for advanced colorectal cancer remain high, it is within a range established for other interventions for advanced cancers and has been shown to improve with increased surgeon and institution experience. Though HIPEC was initially introduced for the management of established peritoneal carcinomatosis, ongoing research into adjuvant HIPEC at the time of curative surgery in patients with locally advanced tumors and HIPEC paired with planned “second-look” surgery in high-risk patients with advanced minimally metastatic disease suggests HIPEC may have an expanded role in the management of advanced colorectal cancer.

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Authors and Affiliations

  1. New York Presbyterian – Weill Cornell Medical Center, Department of General Surgery, New York, NY, USA

    Victoria Aveson

  2. Memorial Sloan-Kettering Cancer Center, Department of Surgery, New York, NY, USA

    Garrett M. Nash

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  1. Victoria Aveson
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  2. Garrett M. Nash
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Correspondence to Garrett M. Nash .

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Editors and Affiliations

  1. City Of Hope National Medical Center, Duarte, CA, USA

    Yuman Fong

  2. Medical College of Wisconsin, Milwaukee, WI, USA

    T. Clark Gamblin

  3. City Of Hope National Medical Center, Duarte, CA, USA

    Ernest S. Han

  4. City Of Hope National Medical Center, Duarte, CA, USA

    Byrne Lee

  5. Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA

    Jonathan S. Zager

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Aveson, V., Nash, G.M. (2020). Data for HIPEC in Colorectal Cancer (T4 Lesions and Metastases). In: Fong, Y., Gamblin, T., Han, E., Lee, B., Zager, J. (eds) Cancer Regional Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-28891-4_9

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  • DOI: https://doi.org/10.1007/978-3-030-28891-4_9

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