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Neurologic and Neurodegenerative Diseases of the Larynx pp 143–159Cite as

Parkinson Disease

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Abstract

Parkinson disease is the most common neurodegenerative disease reported worldwide and presents multiple diverse and disparate manifestations over a prolonged disease course. At any point, speech and swallowing functions may be disturbed, and dysfunctional swallowing, leading to aspiration pneumonia, is the most common cause of death. Current treatments demonstrate limited benefit for speech and swallowing impairments, but novel approaches and greater insight into disease pathogenesis offer hope of improved management of Parkinson disease and its sequelae.

Keywords

  • Parkinson disease
  • Dysphagia
  • Aspiration pneumonia
  • α-Synucleinopathy
  • Hypophonia
  • Lee Silverman Voice Technique
  • Choir therapy

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Fig. 12.1
Fig. 12.2
Fig. 12.3

Abbreviations

AADC:

Aromatic amino acid decarboxylase

AD:

Autosomal dominant

AR:

Autosomal recessive

BBB:

Blood-brain barrier

COMT:

Catechol-O-methyltransferase

DA:

Dopamine

DJ-1:

DJ-1 parkinsonism associated deglycase∗

LRRK2:

Leucine-rich repeat kinase 2∗

Parkin:

Parkin (PARK2)∗

PD:

Parkinson disease

PINK1:

PTEN-induced putative kinase 1∗

RLN:

Recurrent laryngeal nerve

SNCA:

α-Synuclein gene (also called PARK1/4)∗

UES:

Upper esophageal sphincter

VF:

Vocal folds

VFSS:

Video-fluoroscopic swallowing study

∗:

Gene names for genes associated with familial Parkinson disease

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Authors and Affiliations

  1. Department of Otolaryngology, North Shore Hospital Auckland, Auckland, New Zealand

    Jacqui E. Allen

  2. The University of Auckland, Auckland, New Zealand

    Jacqui E. Allen

  3. Department of Speech Science, The University of Auckland, Auckland, New Zealand

    Anna Miles

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Correspondence to Jacqui E. Allen .

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Editors and Affiliations

  1. Division of Otolaryngology–Head & Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, CA, USA

    MD Philip A. Weissbrod

  2. Division of Otolaryngology–Head & Neck Surgery, Department of Surgery, University of Wisconsin–Madison, Madison, WI, USA

    MD David O. Francis

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Allen, J.E., Miles, A. (2020). Parkinson Disease. In: Weissbrod, P., Francis, D. (eds) Neurologic and Neurodegenerative Diseases of the Larynx. Springer, Cham. https://doi.org/10.1007/978-3-030-28852-5_12

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