Abstract
Inflammatory bowel disease is a heterogeneous disorder in terms of severity of inflammation, disease progression, and response to treatment. This implicates difficulties for clinical management of the disease. Tools for a precision medicine approach with optimized diagnosis and disease management and cost-effective treatment strategies and less adverse events are indeed eagerly awaited. Molecular profiling could help in this regard. To date, however, molecular profiling of disease progression and treatment responses has lingered behind in the management of inflammatory bowel disease. Still, thanks to technological advances and optimized study designs, predicting phenotypes of inflammatory bowel disease by molecular profiling using different types of omics has been rapidly evolving. In this chapter, we summarize the current status of prediction of disease progression, response to therapy, and adverse events in inflammatory bowel disease to highlight the recent progress made in molecular profiling.
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Lee, HS., Cleynen, I. (2019). Molecular Profiling of IBD Subtypes and Therapy Responses. In: Hedin, C., Rioux, J., D'Amato, M. (eds) Molecular Genetics of Inflammatory Bowel Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-28703-0_8
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