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Oral Mucosal Immunity and Microbiome pp 165–178Cite as

Neutrophil Interaction with Emerging Oral Pathogens: A Novel View of the Disease Paradigm

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1197))

Abstract

Periodontitis is a multifactorial chronic inflammatory infectious disease that compromises the integrity of tooth-supporting tissues. The disease progression depends on the disruption of host–microbe homeostasis in the periodontal tissue. This disruption is marked by a shift in the composition of the polymicrobial oral community from a symbiotic to a dysbiotic, more complex community that is capable of evading killing while promoting inflammation. Neutrophils are the main phagocytic cell in the periodontal pocket, and the outcome of the interaction with the oral microbiota is an important determinant of oral health. Novel culture-independent techniques have facilitated the identification of new bacterial species at periodontal lesions and induced a reappraisal of the microbial etiology of periodontitis. In this chapter, we discuss how neutrophils interact with two emerging oral pathogens, Filifactor alocis and Peptoanaerobacter stomatis, and the different strategies deploy by these organisms to modulate neutrophil effector functions, with the goal to outline a new paradigm in our knowledge about neutrophil responses to putative periodontal pathogens and their contribution to disease progression.

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Authors and Affiliations

  1. Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, USA

    Irina Miralda, Aruna Vashishta & Silvia M. Uriarte

  2. Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, USA

    Irina Miralda & Silvia M. Uriarte

Authors
  1. Irina Miralda
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  2. Aruna Vashishta
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  3. Silvia M. Uriarte
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Corresponding author

Correspondence to Silvia M. Uriarte .

Editor information

Editors and Affiliations

  1. Division of Oral Diseases, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden

    Georgios N. Belibasakis  & Nagihan Bostanci  & 

  2. Department of Microbiology, University of Pennsylvania, Penn Dental Medicine, Philadelphia, PA, USA

    George Hajishengallis

  3. King’s College London Dental Institute, London, UK

    Michael A. Curtis

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Miralda, I., Vashishta, A., Uriarte, S.M. (2019). Neutrophil Interaction with Emerging Oral Pathogens: A Novel View of the Disease Paradigm. In: Belibasakis, G.N., Hajishengallis, G., Bostanci, N., Curtis, M.A. (eds) Oral Mucosal Immunity and Microbiome. Advances in Experimental Medicine and Biology, vol 1197. Springer, Cham. https://doi.org/10.1007/978-3-030-28524-1_12

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