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RPE Autofluorescence

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Retinal Pigment Epithelium in Health and Disease

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Abstract

Fundus autofluorescence is essentially determined by the fluorophores of the retinal pigment epithelium. The retinal pigment epithelium plays a crucial role in many retinal diseases. Metabolic processes of the RPE lead in a unique way to changes in autofluorescence, especially triggered by lipofuscin and melanolipofuscin. The examination of autofluorescence therefore extends the understanding of pathophysiology of diseases and disease progression. As a result of considerable technical advances, even single intracellular granules can be analysed in detail today. These techniques will become relevant for clinical examinations in the future.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, HSK Wiesbaden, University of Mainz, Wiesbaden, Germany

    Stefan Dithmar

  2. Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany

    Nil Celik

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  1. Stefan Dithmar
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  2. Nil Celik
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Editors and Affiliations

  1. Department of Ophthalmology, University of Kiel, University Medical Center, Kiel, Schleswig-Holstein, Germany

    Alexa Karina Klettner

  2. Department of Ophthalmology HSK Wiesbaden, University of Mainz, Wiesbaden, Germany

    Stefan Dithmar

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Dithmar, S., Celik, N. (2020). RPE Autofluorescence. In: Klettner, A., Dithmar, S. (eds) Retinal Pigment Epithelium in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-28384-1_13

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  • DOI: https://doi.org/10.1007/978-3-030-28384-1_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-28383-4

  • Online ISBN: 978-3-030-28384-1

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