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Microcirculation pp 45–54Cite as

Dynamic Control of Microvessel Diameters by Metabolic Factors

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Abstract

To maintain tissue function under steady state conditions and under increased workload, an adequate regulation of microvascular diameters is required. Microvessels continuously adapt to hemodynamic and metabolic stimuli. Vascular diameter increase in response to flow-induced shear stress establishes a positive feedback loop causing diameters of low-flow vessels to further decrease. This is balanced by metabolic signals released from vessels, tissue or red blood cells which can increase vascular diameters in undersupplied regions thus providing negative feedback regulation. Perturbation of these mechanisms leads to vascular maladaptation and microvascular dysfunction which underlies a multitude of clinical conditions possibly including myocardial angina in the absence of epicardial stenosis.

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Author information

Authors and Affiliations

  1. Department of Physiology, Charité Universitätsmedizin Berlin, Berlin, Germany

    Axel R. Pries & Bettina Reglin

  2. Deutsches Herzzentrum Berlin, Berlin, Germany

    Axel R. Pries

Authors
  1. Axel R. Pries
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  2. Bettina Reglin
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Corresponding author

Correspondence to Axel R. Pries .

Editor information

Editors and Affiliations

  1. Department of Cardiology, Carol Davila University of Medicine, Bucharest, Romania

    Maria Dorobantu

  2. Cardiovascular Program-ICCC, IR- Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain

    Lina Badimon

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Pries, A.R., Reglin, B. (2020). Dynamic Control of Microvessel Diameters by Metabolic Factors. In: Dorobantu, M., Badimon, L. (eds) Microcirculation. Springer, Cham. https://doi.org/10.1007/978-3-030-28199-1_3

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  • DOI: https://doi.org/10.1007/978-3-030-28199-1_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-28198-4

  • Online ISBN: 978-3-030-28199-1

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