Abstract
Non-Melanocytic Skin Cancers: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular invasion, lymph node involvement, and the status of excision margins. Current WHO Classifications of Malignant Tumours and TNM8 are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response. A summary is given of the more common non-carcinoma malignancies that are encountered at this site in diagnostic practice.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Bibliography
Alsaad KO, Obaidat NA, Ghazarian D. Skin adnexal neoplasms—part 1: an approach to tumours of the pilosebaceous unit. J Clin Pathol. 2007;60:145–59.
Allen KJ, Cappel MA, Killian JM, Brewer JD. Basosquamous carcinoma and metatypical basal cell carcinoma: a review of treatment with Mohs micrographic surgery. Int J Dermatol. 2014;53:1395–403.
Asher RG, Hollowood K. Primary cutaneous lymphoma: An overview based on the WHO–EORTC classification. Diagn Histopathol. 2010;16:168–81.
Baxter JM, Patel AM, Varma S. Facial basal cell carcinoma. BMJ. 2012;345:37–42.
Calonje JE, Brenn T, Lazar AJ, McKee PH. McKee’s Pathology of the Skin with Clinical Correlations. 4th ed. Philadelphia: Elsevier Saunders; 2012.
Carr RA, Taibjee SM, Turnbull N, Attili S. Follicular squamous cell carcinoma is an under-recognised common skin tumour. Diagn Histopathol. 2014;20:289–96.
Cerroni L. Lymphoproliferative lesions of the skin. J Clin Pathol. 2006;59:813–26.
Cho-Vega JH, Medeiros LJ, Prieto VG, Vega F. Leukemia cutis. Am J Clin Pathol. 2008;129:130–42.
Elder DE, Massi D, Scolyer RA, Willemze R. WHO classification of skin tumours. 4th ed. Lyon: IARC; 2018.
Fernandez-Flores A. Considerations on the measurement of follicular squamous cell carcinoma. Am J Dermatopathol. 2013;35:135–7.
Goh SGN, Calonje E. Cutaneous vascular tumours: an update. Histopathology. 2008:661–73.
Leonard N. Cutaneous metastases: where do they come from and what can they mimic? Curr Diagn Pathol. 2007;13:320–30.
Llombart B, Monteagudo C, Lopez-Guerrero JA, Carda C, Jorda E, Sanmartin O, Almenar S, Molina I, Martin JM, Llombart-Bosch A. Clinicopathological and immunohistochemical analysis of 20 cases of Merkel cell carcinoma in search of prognostic markers. Histopathology. 2005;46:622–34.
Motley R, Kersey P, Lawrence C. Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma. Br J Dermatol. 2002;146:18–25.
Murphy GF, Elder DE. Non-melanocytic tumors of the skin. In: Atlas of tumor pathology. 3rd series. Fascicle 1. Washington: AFIP; 1991.
Obaidat NA, Alsaad KO, Ghazarian D. Skin adnexal neoplasms—part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol. 2007;60:129–44.
Ogawa T, Kiuru M, Konia TH, Fung MA. Acantholytic squamous cell carcinoma is usually associated with hair follicles, not acantholytic actinic keratosis, and is not “high risk”: Diagnosis, management, and clinical outcomes in a series of 115 cases. J Am Acad Dermatol. 2016;76:327–33.
Public Health England. National Cancer Registration and Analysis Service. Non-melanoma skin cancer in England, Scotland, Northern Ireland, and Ireland NCIN Data Briefing; (n.d.). http://www.ncin.org.uk/view?rid=2178.
Shriner DL, McCoy DK, Goldberg DJ, Wagner RF Jr. Mohs’ micrographic surgery. J Am Acad Dermatol. 1998;39:79–97.
Slater DN. Classification and diagnosis of cutaneous lymphoproliferative disorders. In: Lowe DG, Underwood SCE, editors. Recent advances in histopathology 20. London: RSM Press; 2003. p. 53–72.
Telfer NR, Colver GB, Morton CA. Guidelines for the management of basal cell carcinoma. Br J Dermatol. 2008;159:35–48.
The Royal College of Pathologists. Cancer Datasets (Basal cell carcinoma, malignant melanoma, invasive squamous cell carcinoma, Merkel cell carcinoma, primary cutaneous adnexal carcinomas) and tissue pathway for dermatopathology; (n.d.). https://www.rcpath.org/profession/guidelines/cancer-datasets-and-tissue-pathways.html.
Van Roggen JFG, Lim TK, Hogendoorn PCW. The histopathological differential diagnosis of mesenchymal tumours of the skin. Curr Diagn Pathol. 2005;11:371–89.
Weedon D. Skin pathology. 3rd ed. London: Churchill Livingstone; 2009.
Weedon D, LeBoit P, Burg G, Sarasin A. World Health Organisation classification of tumours. Pathology and genetics. Tumours of the skin. Lyon: IARC Press; 2005.
Yanofsky VR, Mercer SE, Phelps RG. Histopathological variants of cutaneous squamous cell carcinoma: a review. J Skin Cancer. 2010;2011:210813.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Boyle, D.P. (2020). Non-Melanocytic Skin Cancers. In: Boyle, D., Allen, D. (eds) Histopathology Reporting. Springer, Cham. https://doi.org/10.1007/978-3-030-27828-1_20
Download citation
DOI: https://doi.org/10.1007/978-3-030-27828-1_20
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-27827-4
Online ISBN: 978-3-030-27828-1
eBook Packages: MedicineMedicine (R0)