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Genomics, Proteomics, and Metabolomics for Stem Cells Monitoring in Regenerative Medicine

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Genomics, Proteomics, and Metabolomics

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Stem cells are undifferentiated cells that contain long-term potency for differentiation and self-renewal. There is a fine interest to know the mechanisms for stem cells behavior, and use their capacity in medicine researches, developmental and aging studies. In addition to growth factors and morphogens, multiple metabolic pathways take part in the stem cell fate regulation. In current chapter we aim to discuss about stem cell metabolomics such as the ways to maintain stem cell in proliferation and quiescence mood in the hypoxic and normoxic niche. We then describe the mechanisms by which stem cells retain their multipotency properties. Several mechanisms such as oxidative stress which involve in aging reviewed below to explain the decrease in stem cells numbers and function. Then we will go to discuss about the genomics of stem cells. The regulatory genome is significantly important in maintaining pluripotency, therefore scientists attempt to find other components that involved in stem cells differentiation or maintaining self-renewal. We will then explain the specific features of the genomics of IPCs and ESCs. The present work aimed to use the newest genetic engineering techniques combined with in vitro and in vivo imaging applications to realize the full translational potential of hESCs and iPSCs.

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Authors and Affiliations

  1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Saeed Heidari-Keshel, Azam Rahimi & Arash Khojasteh

  2. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mostafa Rezaei-Tavirani

  3. Biomedical and Electrical Engineering Department, School of Engineering, University of Bradford, Bradford, UK

    Farshid Sefat

  4. Interdisciplinary Research Centre in Polymer Science & Technology (IRC Polymer), University of Bradford, Bradford, UK

    Farshid Sefat

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  1. Saeed Heidari-Keshel
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  1. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism, Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Metabolomics and Genomics Research Center, Endocrinology and Metabolism, Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Babak Arjmand

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Heidari-Keshel, S., Rahimi, A., Rezaei-Tavirani, M., Sefat, F., Khojasteh, A. (2019). Genomics, Proteomics, and Metabolomics for Stem Cells Monitoring in Regenerative Medicine. In: Arjmand, B. (eds) Genomics, Proteomics, and Metabolomics. Stem Cell Biology and Regenerative Medicine. Humana, Cham. https://doi.org/10.1007/978-3-030-27727-7_2

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