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Restoring Vision Using Stem Cells and Transplantation

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1185)

Abstract

The replacement of retinal cells, or the support of surviving retinal neurons, in a degenerated retina presents a significant challenge in the fields of ophthalmology and regenerative medicine. Stem cell-based therapies are being explored as an approach for treating retinal dystrophies, such as retinitis pigmentosa (RP), Stargardt’s disease, and age-related macular degeneration (AMD). This review provides an update on the recent progress made toward the restoration of vision lost to degenerative disease using stem cell-based transplantation strategies and the challenges that need to be overcome. Both retinal pigmented epithelium (RPE) and photoreceptor replacement therapies are discussed.

Keywords

  • Cell therapy
  • Cell transplantation
  • Retinal degeneration
  • Retinitis pigmentosa
  • Age-related macular disease
  • Stem cell therapy
  • Retinal organoids
  • Translational research
  • In vitro retinal pigmented epithelium
  • In vitro photoreceptor cells

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Fig. 92.1

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Acknowledgment

This work was supported by the MRC UK grant MR/M015688/1, GOSHCC, and the NIHR.

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Correspondence to Jane C. Sowden .

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Cuevas, E., Parmar, P., Sowden, J.C. (2019). Restoring Vision Using Stem Cells and Transplantation. In: Bowes Rickman, C., Grimm, C., Anderson, R., Ash, J., LaVail, M., Hollyfield, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 1185. Springer, Cham. https://doi.org/10.1007/978-3-030-27378-1_92

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