Abstract
Diabetic retinopathy (DR) is a multifaceted disease, combining the deleterious effects of hyperglycemia and the propensity for accumulation of reactive oxygen species. Studies indicate that auto-oxidation of glucose, reduced antioxidant activity, and metabolic aberrations contribute to the pathogenesis of DR. These abnormalities stem from a fundamental imbalance between ROSs and antioxidant scavengers. To correct this imbalance and downstream effects, we propose that superoxide dismutase 3 (SOD3) is a viable therapeutic target for DR.
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References
Al-Gubory KH, Fowler PA, Garrel C (2010) The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int J Biochem Cell Biol 42:1634–1650
Batinic-Haberle I, Tovmasyan A et al (2014) SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal 20:2372–2415
Calderon GD, Juarez OH et al (2017) Oxidative stress and diabetic retinopathy: development and treatment. Eye 31:1122–1130
Chen B, Caballero S et al (2009) Delivery of antioxidant enzyme genes to protect against ischemia/reperfusion-induced injury to retinal microvasculature. Invest Ophthalmol Vis Sci 50:55877–55595
Evans JL, Goldfine ID et al (2002) Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 42:599–622
Faraci FM, Didion SP (2004) Vascular protection superoxide dismutase isoforms in the vessel wall. Arterioscler Thromb Vasc Biol 24:1367–1373
GarcÃa-Aguilar A, Cuezva JM (2018) A review of the inhibition of the mitochondrial ATP synthase by IF1 in vivo: reprogramming energy metabolism and inducing mitohormesis. Front Physiol 9:1322
Gast TJ, Fu X et al (2016) A computational model of peripheral photocoagulation for the prevention of progressive diabetic capillary occlusion. J Diabetes Res 2016:2508381
Gosbell AD, Stefanovic N (2006) Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1. Invest Ophthalmol Vis Sci 47:2613–2622
Hakki Kalkan I, Suher M (2013) The relationship between the level of glutathione impairment of glucose metabolism and complications of diabetes mellitus. Pak J Med 29:938–942
Hartsock MJ, Cho H et al (2016) A mouse model of retinal ischemia-reperfusion injury through elevation of intraocular pressure. J Vis Exp (113)
Juha P. Laurila, Lilja E. Laatikainen, Maria D. Castellone, Mikko O. Laukkanen, Eshel Ben-Jacob, (2009) SOD3 Reduces Inflammatory Cell Migration by Regulating Adhesion Molecule and Cytokine Expression. PLoS ONE 4 (6):e5786
Klein JA, Ackerman SL (2003) Oxidative stress, cell cycle, and neurodegeneration. J Clin Investig 111:785–793
Kowluru RA, Chan PS (2007) Oxidative stress and diabetic retinopathy. Exp Diabetes Res 2007:43603
Laight DW, Carrier MJ, Anggard EE (2000) Antioxidants, diabetes and endothelial dysfunction. Cardiovasc Res 47:457–464
Laukkanen MO, Cammarota F et al (2015) Extracellular superoxide dismutase regulates the expression of small GTPase regulatory proteins GEFs, GAPs, and GDI. PLoS One 10(3):e0121441
Markus P. Schneider, Jennifer C. Sullivan, Paul F. Wach, Erika I. Boesen, Tatsuo Yamamoto, Tohru Fukai, David G. Harrison, David M. Pollock, Jennifer S. Pollock, (2010) Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury. Kidney International 78 (4):374-381
Panfoli I, Calzia D et al (2012) Extra-mitochondrial aerobic metabolism in retinal rod outer segments: new perspectives in retinopathies. Med Hypotheses 78:423–427
Pattison DI, Rahmanto AS, Davies MJ (2012) Photo-oxidation of proteins. Photochem Photobiol Sci 11:38–53
Pham-Huy LA, He H, Pham-Huy C (2008) Free radicals, antioxidants in disease and health. Int J Biomed Sci 4:89–96. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614697/.
Rahimi N (2012) The ubiquitin-proteasome system meets angiogenesis. Mol Cancer Ther 11:538
Sahajpal NS, Goel RK et al (2018) Pathological perturbations in diabetic retinopathy: hyperglycemia, AGEs, oxidative stress and inflammatory pathways. Curr Protein Pept Sci 20:92
Seddon JM, Ajani UA et al (1994) Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA 272:1413–1420. https://doi.org/10.1001/jama.1994.03520180037032
Singh B, Bhat HK (2012) Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer. Carcinogenesis 33:2601–2610
Song H, Vijayasarathy C, Zeng Y, Marangoni D, Bush RA, Wu Z, Sieving PA (2016) NADPH oxidase contributes to photoreceptor degeneration in constitutively active RAC1 mice. Invest Ophthalmol Vis Sci 57:2864–2875
Usui S, Komeima K et al (2009) Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Mol Ther 17:778–786
Young TA, Cunningham CC, Bailey SM (2002) Reactive oxygen species production by mitochondrial respiratory chain in isolated rat hepatocytes and liver mitochondria. Arch Biochem Biophys 405:65–72
Zeng H, Ding M et al (2014) Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice. Neuroscience 275:54–61
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Ikelle, L., Naash, M.I., Al-Ubaidi, M.R. (2019). Oxidative Stress, Diabetic Retinopathy, and Superoxide Dismutase 3. In: Bowes Rickman, C., Grimm, C., Anderson, R., Ash, J., LaVail, M., Hollyfield, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 1185. Springer, Cham. https://doi.org/10.1007/978-3-030-27378-1_55
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DOI: https://doi.org/10.1007/978-3-030-27378-1_55
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