Abstract
The resistance of common or resurgent pathogens to standard antibiotic therapies is a significant health problem, so the need for new antimicrobial sources is imperative. It is widely known that the most promising source of new drugs remains natural products, mainly those of microbial origin. Such is the case of microbial nanoparticles (NPs) which have unusual physical, chemical, and biological properties like as powerful antibacterial activities. While NPs synthesized by chemical methods involve hazardous and expensive processes, nano-biosynthesis is a green technology by which NPs are obtained through biological processes such as the reduction of a metal salt by the action of biomolecules.
The aim of this chapter is to provide an overview of the continuing central role of natural products like the NPs in the discovery and development of new pharmaceuticals. It is known that Actinobacteria are excellent producers of specialized biomolecules, such as NPs. Moreover, it was demonstrated that they have in their genomes many more biosynthetic pathways, which constitute an untapped promising source of new antibacterial molecules and other therapeutic agents. Here, we focus on those heavy metal-resistant strains, due to biogenic NPs are synthesized by simple processes of metal reductions which can naturally occur as part of cellular detoxification mechanisms. In this context, a brief description of the ways of the NPs bioproduction is given. Although extracellular production of metal NPs has more commercial applications in several areas, intracellular production is of the particular dimension and with less polydispersity. This is remarkable due to the control over particle size, and polydispersity is needed to be established for biotechnological purposes. Also, a brief overview of some of the most important methods for nanoparticle characterization is provided. The most applied techniques in NPs characterization are ultraviolet-visible (UV-vis) spectrophotometer, transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), dynamic light scattering (DLS), X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Zeta potential measurement, particle size analysis (PSA), and energy dispersive X-ray spectroscopy (EDX).
By last, this chapter describes the mechanisms that explain the antimicrobial properties of NPs, and it is believed that the more relevant traits of NPs are related with their surface-reactive groups exposed, leading to the formation of reactive oxygen species (ROS). This is indirectly related to their size, as the size of the particle decreases and its surface area increases and determines the potential number of reactive groups on the particle surface.
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References
Ahmad A, Senapati S, Khan M et al (2003a) Extracellular biosynthesis of monodisperse gold nanoparticles by a novel extremophilic Actinomycete, Thermomonospora sp. Langmuir 19:3550–3553. https://doi.org/10.1021/LA026772L
Ahmad A, Senapati S, Khan MI et al (2003b) Intracellular synthesis of gold nanoparticles by a novel alkalotolerant actinomycete, Rhodococcus species. Nanotechnology 14:824–828. https://doi.org/10.1088/0957-4484/14/7/323
Alani F, Moo-Young M, Anderson W (2012) Biosynthesis of silver nanoparticles by a new strain of Streptomyces sp. compared with Aspergillus fumigatus. World J Microbiol Biotechnol 28:1081–1086. https://doi.org/10.1007/s11274-011-0906-0
Albarracín VH, Alonso-Vega P, Trujillo ME et al (2010) Amycolatopsis tucumanensis sp. nov., a copper-resistant actinobacterium isolated from polluted sediments. Int J Syst Evol Microbiol 60:397–401. https://doi.org/10.1099/ijs.0.010587-0
Alvarez A, Saez J, Davila Costa J et al (2017) Actinobacteria: current research and perspectives for bioremediation of pesticides and heavy metals. Chemosphere 166:41–62. https://doi.org/10.1016/J.CHEMOSPHERE.2016.09.070
AshaRani PV, Low Kah Mun G, Hande MP, Valiyaveettil S (2009) Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3:279–290. https://doi.org/10.1021/nn800596w
Asmathunisha N, Kathiresan K (2013) A review on biosynthesis of nanoparticles by marine organisms. Colloids Surf B Biointerfaces 103:283–287. https://doi.org/10.1016/J.COLSURFB.2012.10.030
Bansal V, Bharde A, Ramanathan R, Bhargava S (2012) Inorganic materials using “unusual” microorganisms. Adv Colloid Interf Sci 179–182:150–168. https://doi.org/10.1016/J.CIS.2012.06.013
Bastús NG, Merkoçi F, Piella J, Puntes V (2014) Synthesis of highly monodisperse citrate-stabilized silver nanoparticles of up to 200 nm: kinetic control and catalytic properties. Chem Mater 26:2836–2846. https://doi.org/10.1021/cm500316k
Beeler E, Singh OV (2016) Extremophiles as sources of inorganic bio-nanoparticles. World J Microbiol Biotechnol 32:156. https://doi.org/10.1007/s11274-016-2111-7
Bentley SD, Chater KF, Cerdeño-Tárraga A-M et al (2002) Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417:141–147. https://doi.org/10.1038/417141a
Bérdy J (2005) Bioactive microbial metabolites. J Antibiot (Tokyo) 58:1–26. https://doi.org/10.1038/ja.2005.1
Borase HP, Salunke BK, Salunkhe RB et al (2014) Plant extract: a promising biomatrix for ecofriendly, controlled synthesis of silver nanoparticles. Appl Biochem Biotechnol 173:1–29. https://doi.org/10.1007/s12010-014-0831-4
Brayner R, Ferrari-Iliou R, Brivois N et al (2006) Toxicological impact studies based on Escherichia coli bacteria in ultrafine ZnO nanoparticles colloidal medium. Nano Lett 6:866–870. https://doi.org/10.1021/NL052326H
Bull AT, Stach JEM (2007) Marine actinobacteria: new opportunities for natural product search and discovery. Trends Microbiol 15:491–499. https://doi.org/10.1016/J.TIM.2007.10.004
Chauhan R, Kumar A, Abraham J (2013) A biological approach to synthesis of silver nanoparticles with Streptomyces sp. JAR1 and its antimicrobial activity. Sci Pharm 81:607–621. https://doi.org/10.3797/scipharm.1302-02
Chauhan N, Narang J, Jain U (2016) Amperometric acetylcholinesterase biosensor for pesticides monitoring utilising iron oxide nanoparticles and poly(indole-5-carboxylic acid). J Exp Nanosci 11:111–122. https://doi.org/10.1080/17458080.2015.1030712
Dasgupta N, Ramalingam C (2016) Silver nanoparticle antimicrobial activity explained by membrane rupture and reactive oxygen generation. Environ Chem Lett 14:477–485. https://doi.org/10.1007/s10311-016-0583-1
Davies J, Davies D (2010) Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev 74:417–433. https://doi.org/10.1128/MMBR.00016-10
Dávila Costa JS, Amoroso MJ (2014) Current biotechnological applications of the genus Amycolatopsis. World J Microbiol Biotechnol 30:1919–1926. https://doi.org/10.1007/s11274-014-1622-3
Dávila Costa JS, Albarracín VH, Abate CM (2011a) Cupric reductase activity in copper-resistant Amycolatopsis tucumanensis. Water Air Soil Pollut 216:527–535. https://doi.org/10.1007/s11270-010-0550-6
Dávila Costa JS, Albarracín VH, Abate CM (2011b) Responses of environmental Amycolatopsis strains to copper stress. Ecotoxicol Environ Saf 74:2020–2028. https://doi.org/10.1016/j.ecoenv.2011.06.017
Dávila Costa JS, Kothe E, Abate CM, Amoroso MJ (2012) Unraveling the Amycolatopsis tucumanensis copper-resistome. Biometals 25:905–917. https://doi.org/10.1007/s10534-012-9557-3
Durán N, Marcato PD, De Souza GIH et al (2007) Antibacterial effect of silver nanoparticles produced by fungal process on textile fabrics and their effluent treatment. J Biomed Nanotechnol 3:203–208. https://doi.org/10.1166/jbn.2007.022
El-Deeb B, Mostafa NY, Altalhi A, Gherbawy Y (2013) Extracellular biosynthesis of silver nanoparticles by bacteria Alcaligenes faecalis with highly efficient anti-microbial property. Int J Chem Eng 30:2051–7858
Erasmus M, Cason ED, van Marwijk J et al (2014) Gold nanoparticle synthesis using the thermophilic bacterium Thermus scotoductus SA-01 and the purification and characterization of its unusual gold reducing protein. Gold Bull 47:245–253. https://doi.org/10.1007/s13404-014-0147-8
Gade AK, Bonde P, Ingle AP et al (2008) Exploitation of Aspergillus niger for synthesis of silver nanoparticles. J Biobaased Mater Bioenergy 2:243–247. https://doi.org/10.1166/jbmb.2008.401
Ghai R, McMahon KD, Rodriguez-Valera F (2012) Breaking a paradigm: cosmopolitan and abundant freshwater actinobacteria are low GC. Environ Microbiol Rep 4:29–35. https://doi.org/10.1111/j.1758-2229.2011.00274.x
Ghazwani A (2015) Biosynthesis of silver nanoparticles by Aspergillus niger, Fusarium oxysporum and Alternaria solani. Afr J Biotechnol 14:2170–2174
Golinska P, Rathod D, Wypij M et al (2017) Mycoendophytes as efficient synthesizers of bionanoparticles: nanoantimicrobials, mechanism, and cytotoxicity. Crit Rev Biotechnol 37:765–778. https://doi.org/10.1080/07388551.2016.1235011
Goodfellow M, Fiedler H-P (2010) A guide to successful bioprospecting: informed by actinobacterial systematics. Antonie Van Leeuwenhoek 98:119–142. https://doi.org/10.1007/s10482-010-9460-2
Hartmann T (2008) The lost origin of chemical ecology in the late 19th century. Proc Natl Acad Sci U S A 105:4541–4546. https://doi.org/10.1073/pnas.0709231105
Hoskisson PA, Sumby P, Smith MCM (2015) The phage growth limitation system in Streptomyces coelicolor a(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity. Virology 477:100–109. https://doi.org/10.1016/J.VIROL.2014.12.036
Huang J, Lin L, Sun D et al (2015) Bio-inspired synthesis of metal nanomaterials and applications. Chem Soc Rev 44:6330–6374. https://doi.org/10.1039/C5CS00133A
Hulkoti N, Taranath T (2014) Biosynthesis of nanoparticles using microbes—a review. Colloids Surfa B Biointerfaces 121:474–483. https://doi.org/10.1016/J.COLSURFB.2014.05.027
Ivask A, Bondarenko O, Jepihhina N, Kahru A (2010) Profiling of the reactive oxygen species-related ecotoxicity of CuO, ZnO, TiO2, silver and fullerene nanoparticles using a set of recombinant luminescent Escherichia coli strains: differentiating the impact of particles and solubilised metals. Anal Bioanal Chem 398:701–716. https://doi.org/10.1007/s00216-010-3962-7
Jain N, Bhargava A, Rathi M et al (2015) Removal of protein capping enhances the antibacterial efficiency of biosynthesized silver nanoparticles. PLoS One 10:e0134337. https://doi.org/10.1371/journal.pone.0134337
Jenke-Kodama H, Sandmann A, Müller R, Dittmann E (2005) Evolutionary implications of bacterial polyketide synthases. Mol Biol Evol 22:2027–2039. https://doi.org/10.1093/molbev/msi193
Kalabegishvili TL, Murusidze IG, Kirkesali EI et al (2015) Possibilities of physical methods in development of microbial nanotechnology. Eur Chem Bull 4:43–49. https://doi.org/10.17628/ECB.2015.4.43-49
Khot L, Sankaran S, Maja J et al (2012) Applications of nanomaterials in agricultural production and crop protection: a review. Crop Prot 35:64–70. https://doi.org/10.1016/J.CROPRO.2012.01.007
Kim JS, Kuk E, Yu KN et al (2007) Antimicrobial effects of silver nanoparticles. Nanomedicine 3:95–101. https://doi.org/10.1016/j.nano.2006.12.001
Lara HH, Ayala-Núñez NV, del Ixtepan Turrent LC, Rodríguez Padilla C (2010) Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria. World J Microbiol Biotechnol 26:615–621. https://doi.org/10.1007/s11274-009-0211-3
Liu WT (2006) Nanoparticles and their biological and environmental applications. J Biosci Bioeng 102:1–7. https://doi.org/10.1263/JBB.102.1
Mahmoudi M, Simchi A, Imani M, Häfeli UO (2009) Superparamagnetic iron oxide nanoparticles with rigid cross-linked polyethylene glycol fumarate coating for application in imaging and drug delivery. J Phys Chem C 113:8124–8131. https://doi.org/10.1021/jp900798r
Manivasagan P, Venkatesan J, Sivakumar K, Kim SK (2013) RETRACTED: marine actinobacterial metabolites: current status and future perspectives. Microbiol Res 168:311–332. https://doi.org/10.1016/J.MICRES.2013.02.002
Marambio-Jones C, Hoek EMV (2010) A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment. J Nanopart Res 12:1531–1551. https://doi.org/10.1007/s11051-010-9900-y
McLean TC, Hoskisson PA, Seipke RF (2016) Coordinate regulation of antimycin and candicidin biosynthesis. mSphere 1:e00305–e00316. https://doi.org/10.1128/mSphere.00305-16
Noda-García L, Barona-Gómez F (2013) Enzyme evolution beyond gene duplication. Mob Genet Elem 3:e26439. https://doi.org/10.4161/mge.26439
Olano C, Méndez C, Salas JA (2009) Antitumor compounds from marine actinomycetes. Mar Drugs 7:210–248. https://doi.org/10.3390/md7020210
Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL (2007) Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 6:29–40. https://doi.org/10.1038/nrd2201
Polti MA, Amoroso MJ, Abate CM (2007) Chromium(VI) resistance and removal by actinomycete strains isolated from sediments. Chemosphere 67:660–667. https://doi.org/10.1016/j.chemosphere.2006.11.008
Polti M, Amoroso M, Abate C (2010) Chromate reductase activity in Streptomyces sp. MC1. J Gen Appl Microbiol 56:11–18. https://doi.org/10.2323/jgam.56.11
Raghupathi KR, Koodali RT, Manna AC (2011) Size-dependent bacterial growth inhibition and mechanism of antibacterial activity of zinc oxide nanoparticles. Langmuir 27:4020–4028. https://doi.org/10.1021/la104825u
Rai M, Gade A, Yadav A (2011) Biogenic nanoparticles: an introduction to what they are, how they are synthesized and their applications. In: Metal nanoparticles in microbiology. Springer, Berlin/Heidelberg, pp 1–14
Ramanathan R, O’Mullane AP, Parikh RY et al (2011) Bacterial kinetics-controlled shape-directed biosynthesis of silver nanoplates using Morganella psychrotolerans. Langmuir 27:714–719. https://doi.org/10.1021/la1036162
Ridley CP, Lee HY, Khosla C (2008) Evolution of polyketide synthases in bacteria. Proc Natl Acad Sci U S A 105:4595–4600. https://doi.org/10.1073/pnas.0710107105
Roduner E (2006) Size matters: why nanomaterials are different. Chem Soc Rev 35:583. https://doi.org/10.1039/b502142c
Sadhasivam S, Shanmugam P, Yun K (2010) Biosynthesis of silver nanoparticles by Streptomyces hygroscopicus and antimicrobial activity against medically important pathogenic microorganisms. Colloids Surf B Biointerfaces 81:358–362. https://doi.org/10.1016/J.COLSURFB.2010.07.036
Sharma K, Singh G, Singh G et al (2015) Silver nanoparticles: facile synthesis and their catalytic application for the degradation of dyes. RSC Adv 5:25781–25788. https://doi.org/10.1039/C5RA02909K
Shi C, Zhu N, Cao Y, Wu P (2015) Biosynthesis of gold nanoparticles assisted by the intracellular protein extract of Pycnoporus sanguineus and its catalysis in degradation of 4-nitroaniline. Nanoscale Res Lett 10:147. https://doi.org/10.1186/s11671-015-0856-9
Siddiqi KS, Husen A (2016) Fabrication of metal and metal oxide nanoparticles by algae and their toxic effects. Nanoscale Res Lett 11:363. https://doi.org/10.1186/s11671-016-1580-9
Składanowski M, Wypij M, Laskowski D et al (2017) Silver and gold nanoparticles synthesized from Streptomyces sp. isolated from acid forest soil with special reference to its antibacterial activity against pathogens. J Clust Sci 28:59–79. https://doi.org/10.1007/s10876-016-1043-6
Stark WJ, Stoessel PR, Wohlleben W, Hafner A (2015) Industrial applications of nanoparticles. Chem Soc Rev 44:5793–5805. https://doi.org/10.1039/C4CS00362D
Vaghari H, Jafarizadeh-Malmiri H, Mohammadlou M et al (2016) Application of magnetic nanoparticles in smart enzyme immobilization. Biotechnol Lett 38:223–233. https://doi.org/10.1007/s10529-015-1977-z
Wen L, Zeng P, Zhang L et al (2016) Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing. Int J Nanomedicine 11:2757–2767. https://doi.org/10.2147/IJN.S106662
WHO (2015) Worldwide country situation analysis: response to antimicrobial resistance. World Health Organization, Geneva
Wypij M, Golinska P, Dahm H, Rai M (2017) Actinobacterial-mediated synthesis of silver nanoparticles and their activity against pathogenic bacteria. IET Nanobiotechnol 11:336–342
Xia T, Kovochich M, Brant J et al (2006) Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6:1794–1807. https://doi.org/10.1021/NL061025K
Xu C, Sun S (2013) New forms of superparamagnetic nanoparticles for biomedical applications. Adv Drug Deliv Rev 65:732–743. https://doi.org/10.1016/J.ADDR.2012.10.008
Xu J, Sun J, Wang Y et al (2014) Application of iron magnetic nanoparticles in protein immobilization. Molecules 19:11465–11486. https://doi.org/10.3390/molecules190811465
Xue B, He D, Gao S et al (2016) Biosynthesis of silver nanoparticles by the fungus Arthroderma fulvum and its antifungal activity against genera of Candida, Aspergillus and Fusarium. Int J Nanomedicine 11:1899–1906. https://doi.org/10.2147/IJN.S98339
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Costa, D. et al. (2020). Nanoparticles for New Pharmaceuticals: Metabolites from Actinobacteria. In: Dasgupta, N., Ranjan, S., Lichtfouse, E. (eds) Environmental Nanotechnology Volume 4. Environmental Chemistry for a Sustainable World, vol 32. Springer, Cham. https://doi.org/10.1007/978-3-030-26668-4_6
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