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Painful Skin Nodules, Prolonged Fever and Cervical Lymphadenopathy

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Abstract

  • Disseminated non-tuberculous mycobacterial infections occurring in a young patient should raise the suspicion of an underlying primary immunodeficiency

  • First line investigations should comprise a search for mendelian susceptibility to mycobacterial disease (MSMD), in particular IL-12:IFN-γ loop defects

  • Patients with acquired defects that could disrupt the IFN-γ-associated immune pathway, such as pathological presence of anti-IFN-γ autoantibodies with neutralizing capacity, display a similar immunodeficiency picture to MSMD

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Authors and Affiliations

  1. Dermatology Service, KK Women’s and Children’s Hospital, Singapore, Singapore

    Michelle N. G. Ying, Emily Yiping Gan & Jean Aan Mark Koh

Authors
  1. Michelle N. G. Ying
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  2. Emily Yiping Gan
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  3. Jean Aan Mark Koh
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Editor information

Editors and Affiliations

  1. Student’s Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Farzaneh Rahmani

  2. Department of Immunology, School of Medicine, Research Center for Immunodeficiencies (RCID), Children’s Medical Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Nima Rezaei

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Ying, M.N.G., Gan, E.Y., Koh, J.A.M. (2020). Painful Skin Nodules, Prolonged Fever and Cervical Lymphadenopathy. In: Rahmani, F., Rezaei, N. (eds) Pediatric Autoimmunity and Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-26280-8_34

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  • DOI: https://doi.org/10.1007/978-3-030-26280-8_34

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-26279-2

  • Online ISBN: 978-3-030-26280-8

  • eBook Packages: MedicineMedicine (R0)

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