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Genomic Drivers in Follicular Lymphoma

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Follicular Lymphoma

Abstract

This chapter discusses the genetic mutation landscape in follicular lymphoma (FL) and its role in tumor initiation and progression. The t(14;18)(q32;q21) translocation that places the BCL2 oncogene under control of the immunoglobulin heavy-chain enhancer is a genetic hallmark of FL. However, mutations in chromatin modifying genes (CMGs) such as KMT2D, CREBBP, and EZH2 have emerged as key genetic hits that promote lymphomagenesis. These mutations, and others that are implicated in FL, are discussed in this chapter. We provide insight into their biological function and the mechanisms by which their deregulation contributes to lymphomagenesis, and we discuss their role in disease genesis and progression.

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  1. University of Texas MD Anderson Cancer Center, Department of Lymphoma/Myeloma, Houston, TX, USA

    Saber Tadros & Michael R. Green

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    Nathan H. Fowler

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Tadros, S., Green, M.R. (2020). Genomic Drivers in Follicular Lymphoma. In: Fowler, N. (eds) Follicular Lymphoma. Springer, Cham. https://doi.org/10.1007/978-3-030-26211-2_3

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