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Plaque Erosion

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Cardiovascular OCT Imaging

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Abstract

Plaque rupture and erosion are the two most common causes of acute coronary syndromes (ACS). Although plaque rupture has been well-characterized by autopsy and clinical studies, current knowledge of plaque erosion remains poor. A combination of insights from autopsy, in vitro pathobiology, and in vivo optical coherence tomography (OCT) imaging studies has led to the understanding that plaques prone to rupture and erosion are fundamentally different. Consequently, their optimal management may also differ. Early clinical studies suggest that, in a carefully selected subset of patients with plaque erosion as detected by OCT, treatment with anti-thrombotic therapy alone may be a feasible and safe alternative to stent placement. Further well-powered prospective studies are necessary to investigate such tailored treatment of ACS due to plaque erosion and rupture.

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  1. Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Vikas Thondapu & Ik-Kyung Jang

  2. Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Peter Libby

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    Ik-Kyung Jang

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Thondapu, V., Libby, P., Jang, IK. (2020). Plaque Erosion. In: Jang, IK. (eds) Cardiovascular OCT Imaging. Springer, Cham. https://doi.org/10.1007/978-3-030-25711-8_6

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