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Reviews on Biomarker Studies in Aging and Anti-Aging Research pp 129–154Cite as

Gut Microbiota and Microbiota-Related Metabolites as Possible Biomarkers of Cognitive Aging

Part of the Advances in Experimental Medicine and Biology book series (PMISB,volume 1178)

Abstract

Gut microbiota composition and functionality can influence the pathophysiology of age-related cognitive impairment and dementia, according to a large number of animal studies. The translation of this concept to humans is still uncertain, due to the relatively low number of clinical studies focused on fecal microbiota and large number of environmental factors that influence the microbiota composition. However, the fecal microbiota composition of older patients with dementia is deeply different from that of healthy active controls, conditioning a different metabolic profile. The possible use of fecal microbiota-related parameters and microbiota-derived metabolites as biomarkers of cognitive performance and dementia is critically reviewed in this paper, focusing on the most promising areas of research for the future.

Keywords

  • Alzheimer’s disease
  • Mild cognitive impairment
  • Biodiversity
  • Firmicutes/Bacteroidetes ratio
  • Microbial metabolites

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Acknowledgements

All authors have no conflict of interest to declare. No funding is reported for this manuscript.

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Authors and Affiliations

  1. Geriatric Rehabilitation Department, University-Hospital of Parma, Parma, Italy

    Andrea Ticinesi, Antonio Nouvenne, Claudio Tana, Beatrice Prati & Tiziana Meschi

  2. Microbiome Research Hub, University of Parma, Parma, Italy

    Andrea Ticinesi, Antonio Nouvenne & Tiziana Meschi

  3. Department of Medicine and Surgery, University of Parma, Parma, Italy

    Tiziana Meschi

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  1. Andrea Ticinesi
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  2. Antonio Nouvenne
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  3. Claudio Tana
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Correspondence to Andrea Ticinesi .

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  1. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Dr. Paul C. Guest

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Ticinesi, A., Nouvenne, A., Tana, C., Prati, B., Meschi, T. (2019). Gut Microbiota and Microbiota-Related Metabolites as Possible Biomarkers of Cognitive Aging. In: Guest, P. (eds) Reviews on Biomarker Studies in Aging and Anti-Aging Research. Advances in Experimental Medicine and Biology(), vol 1178. Springer, Cham. https://doi.org/10.1007/978-3-030-25650-0_8

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