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DNA Systems Under Internal and External Forcing pp 69–93Cite as

Force-Induced Unravelling of DNA Origami

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Abstract

We present the forcible unravelling of some of the largest DNA nanostructures ever simulated with a nucleotide-level coarse-grained model and combine our results with experiments to shed light on the mechanical properties and unfolding pathways of DNA origami systems.

In my own stories I have found that violence is strangely capable of returning my characters to reality and preparing them to accept their moment of grace.

—Flannery O’Connor, from On Her Own Work (1963).

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Authors and Affiliations

  1. John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA

    Dr. Megan Clare Engel

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  1. Dr. Megan Clare Engel
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Correspondence to Megan Clare Engel .

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Engel, M.C. (2019). Force-Induced Unravelling of DNA Origami. In: DNA Systems Under Internal and External Forcing. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-030-25413-1_4

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