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Endovascular Resuscitation and Trauma Management pp 121–133Cite as

REBOA-Induced Ischemia-Reperfusion Injury

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Abstract

Resuscitative endovascular balloon occlusion of the aorta (REBOA)-induced ischemia-reperfusion injury (IRI) represents a complex pathophysiologic process involving dysfunction of intracellular and extracellular components responsible for metabolic, thrombotic, and inflammatory signaling and cellular function. Mitigation strategies following repair and re-establishment of end-organ perfusion include surgical and pharmacologic considerations and adjuncts. Currently, there is a paucity of clinical data concerning the incidence and associated clinical ramifications of IRI following REBOA deployment. Given this limitation, this chapter aims to review IRI as a result of REBOA and discuss the current literature on REBOA-associated IRI mitigation strategies.

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Authors and Affiliations

  1. The Department of Surgery, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    Jigarkumar A. Patel & Joseph M. White

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  1. Jigarkumar A. Patel
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  2. Joseph M. White
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Correspondence to Joseph M. White .

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Editors and Affiliations

  1. Department of Cardiothoracic and Vascular Surgery, Örebro University Hospital, Örebro, Sweden

    Tal Hörer

  2. University of Maryland Medical Center, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA

    Joseph J. DuBose

  3. F. Edward Hebert School of Medicine – “America’s Medical School”, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    Todd E. Rasmussen

  4. The Department of Surgery at Uniformed Services, University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD, USA

    Joseph M. White

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Patel, J.A., White, J.M. (2020). REBOA-Induced Ischemia-Reperfusion Injury. In: Hörer, T., DuBose, J., Rasmussen, T., White, J. (eds) Endovascular Resuscitation and Trauma Management . Hot Topics in Acute Care Surgery and Trauma. Springer, Cham. https://doi.org/10.1007/978-3-030-25341-7_9

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  • DOI: https://doi.org/10.1007/978-3-030-25341-7_9

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