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Liquid-Based Preparations in Thyroid Fine Needle Aspiration

  • Rana S. HodaEmail author
Chapter
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Abstract

  • Estimated annual incidence of thyroid nodules in the United States is 0.1%, which translates to 300,000 new nodules every year.

  • Up to 50% of the general population may have sonographically detectable thyroid nodules, although only up to 5% of these harbor a malignancy.

  • The high incidence of thyroid nodules and low rate of cancer among nodules pose a clinical dilemma.

Keywords

Thyroid cancer statistics Fine needle aspiration (FNA) of thyroid The Bethesda System for Reporting Thyroid Cytopathology TBSRTC Ancillary studies Conventional smears Liquid-based preparations ThinPrep SurePath Advantages and disadvantages of various preparations Laboratory processing techniques 

Suggested Reading

  1. 1.
    Ali SZ, Cibas ES. The Bethesda system for reporting thyroid cytopathology; definitions, criteria, and explanatory notes. 2nd ed. Cham: Springer International Publishing AG; 2018.CrossRefGoogle Scholar
  2. 2.
    American Cancer Society. Key statistics for thyroid cancer. 2019. https://www.cancer.org/cancer/thyroid-cancer/about/key-statistics.html. Accessed 14 Mar 2019.
  3. 3.
    Bessey LJ, Lai NBK, Coorough NE, Chen H, Sippel RS. The incidence of thyroid cancer by FNA varies by age and gender. J Surg Res. 2013;184:761–5.  https://doi.org/10.1016/j.jss.2013.03.086. CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Chang H, Lee E, Lee H, Choi J, Kim A, Kim BH. Comparison of diagnostic values of thyroid aspiration samples using liquid-based preparation and conventional smear: one-year experience in a single institution. APMIS. 2013;121:139–45.  https://doi.org/10.1111/j.1600-0463.2012.02944.x.CrossRefPubMedGoogle Scholar
  5. 5.
    Chong Y, Ji SJ, Kang CS, Lee EJ. Can liquid-based preparation substitute for conventional smear in thyroid fine-needle aspiration? A systematic review based on meta-analysis. Endocr Connect. 2017;6:817–29.  https://doi.org/10.1530/EC-17-0165.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Cibas ES, Ali SZ. The 2017 Bethesda system for reporting thyroid cytopathology. Thyroid. 2017;27:1341–6.  https://doi.org/10.1089/thy.2017.0500.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Cochand-Priollet B, Prat JJ, Polivka M, Thienpont L, Dahan H, Wassef M, et al. Thyroid fine needle aspiration: the morphological features on ThinPrep slide preparations. Eighty cases with histological control. Cytopathology. 2003;14:343–9.CrossRefGoogle Scholar
  8. 8.
    Duncan LD, Forrest L, Law WM Jr, Hubbard E, Stewart LE. Evaluation of thyroid fine-needle aspirations: can ThinPrep be used exclusively to appropriately triage patients having a thyroid nodule? Diagn Cytopathol. 2011;39:341–8.  https://doi.org/10.1002/dc.21392.CrossRefGoogle Scholar
  9. 9.
    Fischer AH, Clayton AC, Bentz JS, Wasserman PG, Henry MR, Souers RJ, et al. Performance differences between conventional smears and liquid-based preparations of thyroid fine-needle aspiration samples: analysis of 47,076 responses in the College of American Pathologists Interlaboratory Comparison Program in Non-Gynecologic Cytology. Arch Pathol Lab Med. 2013;137:26–31.  https://doi.org/10.5858/arpa.2012-0009-CP.CrossRefGoogle Scholar
  10. 10.
    Geers C, Bourgain C. Liquid-based FNAC of the thyroid: a 4-year survey with SurePath. Cancer Cytopathol. 2011;119:58–67.  https://doi.org/10.1002/cncy.20125.CrossRefGoogle Scholar
  11. 11.
    Hoda RS. Non-gynecologic cytology on liquid-based preparations: a morphologic review of facts and artifacts. Diagn Cytopathol. 2007;35:621–34.CrossRefGoogle Scholar
  12. 12.
    Hoda RS, VandenBussche C, Hoda SA. Diagnostic liquid-based cytology. New York: Springer; 2017.CrossRefGoogle Scholar
  13. 13.
    Isik A, Firat D, Yilmaz I, Peker K, Idiz O, Yilmaz B, et al. A survey of current approaches to thyroid nodules and thyroid operations. Int J Surg. 2018;28:100–4.  https://doi.org/10.1016/j.ijsu.2018.04.037.CrossRefGoogle Scholar
  14. 14.
    Kim SY, Kim EK, Moon HJ, Yoon JH, Kwon HJ, Song MK, et al. Combined use of conventional smear and liquid-based preparation versus conventional smear for thyroid fine-needle aspiration. Endocrine. 2016;53:157–65.  https://doi.org/10.1007/s12020-015-0835-z.CrossRefPubMedGoogle Scholar
  15. 15.
    Langer JE, Baloch ZW, McGrath C, Loevner LA, Mandel SJ. Thyroid nodule fine-needle aspiration. Semin Ultrasound CT MR. 2012;33:158–65.  https://doi.org/10.1053/j.sult.2011.12.002.CrossRefPubMedGoogle Scholar
  16. 16.
    Luu MH, Fischer AH, Pisharodi L, Owens CL. Improved preoperative definitive diagnosis of papillary thyroid carcinoma in FNAs prepared with both ThinPrep and conventional smears compared with FNAs prepared with ThinPrep alone. Cancer Cytopathol. 2011;119:68–73.  https://doi.org/10.1002/cncy.20124.CrossRefPubMedGoogle Scholar
  17. 17.
    Michael CW, Hunter B. Interpretation of fine-needle aspirates processed by the ThinPrep technique: Cytologic artifacts and diagnostic pitfalls. Diagn Cytopathol. 2000;23:6–13.CrossRefGoogle Scholar
  18. 18.
    Michael CW, McConnel J, Pecott J, Afify AM, Al-Khafaji B. Comparison of ThinPrep and TriPath PREP liquid-based preparations in nongynecologic specimens: a pilot study. Diagn Cytopathol. 2001;25:177–84.CrossRefGoogle Scholar
  19. 19.
    Moss W, Finegersh A, Pang J, Califano JA, Coffey CS, Orosco R, et al. Needle biopsy of routine thyroid nodules should be performed using a capillary action technique with 24-27 gauge needles: a systematic review and meta-analysis. Thyroid. 2018;28:857–63.  https://doi.org/10.1089/thy.2017.0643.CrossRefPubMedGoogle Scholar
  20. 20.
    Nasuti JF, Tam D, Gupta PK. Diagnostic value of liquid-based (ThinPrep) preparations in nongynecologic cases. Diagn Cytopathol 2001;24:137–141.Google Scholar
  21. 21.
    Nagarajan N, Schneider EB, Ali SZ, Zeiger MA, Olson MT. How do liquid-based preparations of thyroid fine-needle aspiration compare with conventional smears? An analysis of 5475 specimens. Thyroid. 2015;25:308–13.  https://doi.org/10.1089/thy.2014.0394.CrossRefPubMedGoogle Scholar
  22. 22.
    Rosa M. Cytologic features of subacute granulomatous thyroiditis can mimic malignancy in liquid-based preparations. Diagn Cytopathol. 2016;44:682–4.  https://doi.org/10.1002/dc.23495.CrossRefPubMedGoogle Scholar
  23. 23.
    Rossi ED, Morassi F, Santeusanio G, Zannoni GF, Fadda G. Thyroid fine needle aspiration cytology processed by ThinPrep: an additional slide decreased the number of inadequate results. Cytopathology. 2010;21:97–102.  https://doi.org/10.1111/j.1365-2303.2009.00659.x.CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Rossi ED, Raffaelli M, Zannoni GF, Pontecorvi A, Mulè A, Callà C, et al. Diagnostic efficacy of conventional as compared to liquid-based cytology in thyroid lesions: evaluation of 10,360 fine needle aspiration cytology cases. Acta Cytol. 2009;53:659–66.CrossRefGoogle Scholar
  25. 25.
    Rossi ED, Schmitt F. When morphology meets somatic mutations: the new possible scenario in thyroid fine-needle aspiration. Acta Cytol. 2016;60:93–6.  https://doi.org/10.1159/000446796.CrossRefPubMedGoogle Scholar
  26. 26.
    Suzuki A, Hirokawa M, Higuchi M, Takada N, Yamao N, Kuma S, et al. Differentiating between benign follicular nodules and follicular neoplasms in thyroid liquid-based cytology preparations. Diagn Cytopathol. 2016;44:659–64.  https://doi.org/10.1002/dc.23500.CrossRefPubMedGoogle Scholar
  27. 27.
    Tulecke MA, Wang HH. ThinPrep for cytologic evaluation of follicular thyroid lesions: correlation with histologic findings. Diagn Cytopathol. 2004;30:7–13.CrossRefGoogle Scholar
  28. 28.
    Weeks KS, Kahl AR, Lynch CF, Charlton ME. Racial/ethnic differences in thyroid cancer incidence in the United States, 2007-2014. Cancer. 2018;124:1483–91.  https://doi.org/10.1002/cncr.31229. CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Yassa L, Cibas ES, Benson CB, Frates MC, Doubilet PM, Gawande AA, et al. Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation. Cancer. 2007;111:508–16.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.CBLPathRye BrookUSA

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