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Adiposity Is the Enemy: Body Composition and Insulin Sensitivity

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Insulin Resistance

Part of the book series: Contemporary Endocrinology ((COE))

Abstract

It was once thought that declining insulin sensitivity was associated with age—the older you get, the more insulin resistant you become. However, since the advent of advanced imaging techniques in the 1980s and 1990s, it has become apparent that insulin resistance is actually associated with the increase in body fatness that occurs during aging, rather than aging per se. In addition, these imaging techniques have fueled the debate about which regional adipose depot—total body fat, subcutaneous fat, visceral fat, or deep subcutaneous fat—contributes most significantly to insulin resistance. This debate, in turn, has spurred investigation into the mechanisms behind the detrimental effect of body fat on insulin sensitivity. So, the goal of this chapter is to unravel some of the literature dedicated to assessing the effect of body composition on insulin sensitivity and to track the effect of body fatness on insulin sensitivity through the human lifespan—from childhood precursors to adult disease.

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Authors and Affiliations

  1. Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Shanlee M. Davis & Janine Higgins

  2. Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Vanessa D. Sherk

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  1. Section of Pediatric Endocrinology, Children’s Hospital Colorado, Aurora, CO, USA

    Philip S. Zeitler

  2. Department of Pediatrics, Children’s Hospital Colorado, Aurora, CO, USA

    Kristen J. Nadeau

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Davis, S.M., Sherk, V.D., Higgins, J. (2020). Adiposity Is the Enemy: Body Composition and Insulin Sensitivity. In: Zeitler, P., Nadeau, K. (eds) Insulin Resistance. Contemporary Endocrinology. Humana, Cham. https://doi.org/10.1007/978-3-030-25057-7_9

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