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Techniques to Assess Insulin Action in Youth

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Book cover Insulin Resistance

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

Insulin resistance is a central component to several important metabolic disorders and pathological conditions. Various methods are used to assess insulin sensitivity on both an individual level and epidemiological level. Several factors, such as validity, cost, and reproducibility, are important to the clinician and researcher in determining the most appropriate method. The insulin-clamp technique is considered the “gold standard” and provides the purest assessment of in vivo insulin sensitivity. The addition of mathematical modeling to simpler, oral-based assessments, such as the oral glucose tolerance test, is showing promise. In large-scale epidemiological studies, simple fasting surrogate estimates have been shown to be useful. This chapter will describe several methods used to assess insulin sensitivity in pediatrics and their advantages and disadvantages.

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Authors and Affiliations

  1. Kinesiology and Sport Science, Youngstown State University, Youngstown, OH, USA

    Sara Fleet Michaliszyn

  2. Department of Pediatric Endocrinology, Metabolism & Diabetes Mellitus, University of Pittsburgh, School of Medicine, Pediatric Clinical & Translational Research Center, Center for Pediatric Research in Obesity and Metabolism, Pittsburgh, PA, USA

    Silva Arslanian

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  1. Sara Fleet Michaliszyn
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Correspondence to Sara Fleet Michaliszyn .

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Editors and Affiliations

  1. Section of Pediatric Endocrinology, Children’s Hospital Colorado, Aurora, CO, USA

    Philip S. Zeitler

  2. Department of Pediatrics, Children’s Hospital Colorado, Aurora, CO, USA

    Kristen J. Nadeau

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Michaliszyn, S.F., Arslanian, S. (2020). Techniques to Assess Insulin Action in Youth. In: Zeitler, P., Nadeau, K. (eds) Insulin Resistance. Contemporary Endocrinology. Humana, Cham. https://doi.org/10.1007/978-3-030-25057-7_2

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  • DOI: https://doi.org/10.1007/978-3-030-25057-7_2

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  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-030-25055-3

  • Online ISBN: 978-3-030-25057-7

  • eBook Packages: MedicineMedicine (R0)

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