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Nutrigenomics as a Strategy for Neuronal Health

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Early Life Origins of Ageing and Longevity

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 9))

Abstract

Nutrigenomics through gene expression and epigenetic remodeling can program adult health. Diet during pregnancy and lactation (the first 1000 days of life) can modulate offspring’s epigenome leading to tissue specific variations during cell differentiation processes, and may define epigenetic marks associated with long-term effects on offspring neuronal health. Being epigenetics reversible, a healthy diet represents a fundamental opportunity, even after the first 1000 days of life, for maintaining cellular homeostasis. The positive impact of food (i.e. maternal milk, oily fish, fruit and vegetables, curcumin, tea) with its dietary flavonoids (i.e. sulforaphane, quercetin, lutein, resveratrol, carotenoids) and other bioactive compounds (i.e. docosahexanoic acid, melatonin etc.), will be reflected on chromatin structure modulation and DNA methylation which are associated with switching on/off of genes. An anti-inflammatory diet during early-life and across the whole life may represent a key strategy for influencing brain plasticity and for building an “epigenetic memory” useful in developing neuronal resilience against early-life stressors and to prevent age-related neurodegeneration.

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  1. Department of Life and Environmental Sciences, Polytechnic University of the Marche, Ancona, Italy

    Elisabetta Damiani

  2. Unit of Molecular Biology, School of Pharmacy, University of Camerino, Camerino, Italy

    Rosita Gabbianelli

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  1. Elisabetta Damiani
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  2. Rosita Gabbianelli
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Correspondence to Rosita Gabbianelli .

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  1. Laboratory of Epigenetics, Institute of Gerontology, Kiev, Ukraine

    Alexander Vaiserman

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Damiani, E., Gabbianelli, R. (2019). Nutrigenomics as a Strategy for Neuronal Health. In: Vaiserman, A. (eds) Early Life Origins of Ageing and Longevity. Healthy Ageing and Longevity, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-030-24958-8_9

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