Prenatal Undernutrition and Ageing and Longevity

  • Susanne R. de RooijEmail author
Part of the Healthy Ageing and Longevity book series (HAL, volume 9)


Dietary restriction is one of the most extensively studied ways to elongate lifespan, but when species are undernourished before birth, effects are completely opposite. In the present chapter, evidence from animal experimental as well as from human studies is presented demonstrating that prenatal undernutrition increases the risk for ageing-associated diseases of the brain and the body, seems to accelerate the ageing process and decrease lifespan. The findings presented here are of importance from a public health perspective as prenatal nutrition may be a modifiable factor affecting healthy ageing. Also, understanding the processes by which prenatal undernutrition leads to accelerated ageing may provide clues on how we can detect early ageing and implement interventional approaches when conditions are still reversible.


Prenatal undernutrition Ageing Ageing-associated disease Longevity Public health perspective 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Clinical Epidemiology, Biostatistics & Bio InformaticsAmsterdam University Medical Centers, Location AMCAmsterdamThe Netherlands

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