MR Plaque Imaging in Peripheral Artery Disease

  • Jie Sun
  • Chun YuanEmail author


Lower extremity peripheral artery disease (PAD) is one of the most common local manifestations of systemic atherosclerosis. In population studies conducted in the United States and Europe, PAD is estimated to affect approximately 7% of those aged ≥40 years and 21% of those aged ≥65 years. Globally, more than 200 million people are living with PAD, and the number is expected to continue to grow in the next decade due to aging populations worldwide and the increasing prevalence of chronic kidney disease and diabetes. The majority of PAD patients either have no apparent symptoms or have atypical symptoms due to individual variations in lifestyle, pain threshold, or comorbidities. Given the lack of effective medical therapies for PAD beyond exercise programs, understanding and prevention of disease progression at the subclinical stage represent an important question as prophylactic measures are likely most effective in the early stage of PAD.


MR plaque imaging Peripheral artery disease Lower extremity peripheral artery disease PAD 



Ankle-brachial index


Delay alternating with mutation for tailored excitation


Double-echo steady-state


Double inversion recovery


Fast low-angle shot


Fast spin echo


Intraplaque hemorrhage


Motion-sensitized driven-equilibrium prepared rapid gradient echo


Magnetization-prepared rapid acquisition gradient echo


Motion-sensitized driven-equilibrium


Peripheral artery disease


Superficial femoral artery


Sampling perfection with application-optimized contrasts using different flip angle evolution


Walking and Leg Circulation Study



Dr. Sun receives grant support from the American Heart Association (17MCPRP33671077). Dr. Yuan receives grant support from the National Institutes of Health (R01 HL103609 and R01 NS092207) and serves as a member of Philips Radiology Advisory Network.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of RadiologyUniversity of WashingtonSeattleUSA
  2. 2.University of WashingtonSeattleUSA

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