Skip to main content

The Role of Palliative Care in Cirrhosis

  • Chapter
  • First Online:
The Critically Ill Cirrhotic Patient
  • 904 Accesses

Abstract

Cirrhosis is a significantly life-limiting disease, and once a cirrhotic patient has decompensated into critical illness and hospitalization, annual mortality rates become quite high with median survival ≤6 months when MELD scores are ≥21. This chapter will review palliative care concepts in the support and treatment of cirrhotic patients. At the outset, it is essential to note that palliative care is not only the responsibility of palliative care specialists but also of hepatologists, gastroenterologists, hospitalists, or any health-care professional caring for seriously ill patients. A contemporary definition of palliative care including its relationship to hospice will be offered along with reflection on the evolution and the benefits of this relatively new (2008) board-certified specialty. The six common tasks of palliative care, whether provided by the hepatologist or the palliative care specialist, will then be reviewed, with a focus on serious illness communication and advance care planning. Finally, this chapter will close with a review of opioid use in the setting of end-stage liver disease and terminal care of the dying cirrhotic.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ratib S, Fleming KM, et al. 1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998-2009: a large population study. J Hepatol. 2014;60(2):282–9. https://doi.org/10.1016/j.jhep.2013.09.027.

    Article  PubMed  Google Scholar 

  2. Salpeter SR, Luo EJ, Malter DS, Stuart B. Systematic review of noncancer presentations with a median survival of 6 months or less. Am J Med. 2012;125(5):512.e1–6. Epub 2011 Oct 24.

    Article  Google Scholar 

  3. Deaths: final data for 2016. National Vital Statistics Reports. Volume 67, number 5. https://www.cdc.gov/nchs/data/nvsr/nvsr67/nvsr67_05.pdf.

  4. Kelley AS. Defining “serious illness”. J Palliat Med. 2014;17(9):985.

    Article  Google Scholar 

  5. Moss AH, Ganjoo J, Sharma S, et al. Utility of the “Surprise” Question to identify dialysis patients with high mortality. Clin J Am Soc Nephrol. 2008;3(5):1379–84.

    Article  Google Scholar 

  6. Moss AH, Lunney JR, Culp S, et al. Prognostic significance of the “surprise” question in cancer patients. J Palliat Med. 2010;13(7):837–40.

    Article  Google Scholar 

  7. White N, Kupeli N, Vidkerstaff V, Stone P. How accurate is the “Surprise Question” at identifying patients at the end of life? A systematic review and meta-analysis. BMC Med. 2017;15:139. Published online 2017 Aug 2. https://doi.org/10.1186/s12916-017-0907-4.

    Article  PubMed  PubMed Central  Google Scholar 

  8. https://www.nhpco.org/sites/default/files/public/Statistics_Research/2017_Facts_Figures.pdf.

  9. The SUPPORT Principal Investigators. A controlled trial to improve care for seriously ill hospitalized patents. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). JAMA. 1995;274:1591–8.

    Article  Google Scholar 

  10. Barnato AE, Chang CC, et al. Is survival better at hospitals with higher “End-of-Life” treatment intensity? Med Care. 2010;48(2):125–32.

    Article  Google Scholar 

  11. Riley GF, Lubitz JD. Long-term trends in medicare payments in the last year of life. Health Serv Res. 2010;45(2):565–76.

    Article  Google Scholar 

  12. Kelley AS, McGarry K, Fahle S, et al. Out of pocket spending in the last 5 years of life. J Gen Intern Med. 2013;28(2):304–9.

    Article  Google Scholar 

  13. Barnato AE, Herndon MB, et al. Are regional variations in end-of-life care intensity explained by patient preferences? A study of the US medicare population. Med Care. 2007;45(5):386–93.

    Article  Google Scholar 

  14. Steinhauser KE, Christakis NA, et al. Factors considered important at the end of life by patients, family, physicians, and other care providers. JAMA. 2000;284(19):2476–82.

    Article  CAS  Google Scholar 

  15. Lorenz K, Lynn J, et al. Evidence for improving palliative care at the end of life. Ann Intern Med. 2008;148:147–59.

    Article  Google Scholar 

  16. Wagner-Johnson N, Carson K, Grossman S. High outpatient pain intensity scores predict impending hospital admissions in patients with cancer. J Pain Symptom Manage. 2010;39(2):180–5.

    Article  Google Scholar 

  17. Purcell WT, Grossman SA, et al. Abstract No. 2963, Proc Am Soc Clin Oncol. 2003;22.

    Google Scholar 

  18. Riolfi M, Buja A, et al. Effectiveness of palliative home-care services in reducing hospital admissions and determinants of hospitalization for terminally ill patients. Palliat Med. 2014;28(5):403–11.

    Article  Google Scholar 

  19. Norton SA, Hogan LA, et al. Proactive palliative care in the medical intensive care unit: effects on length of stay for selected high-risk patients. Crit Care Med. 2007;35(6):1530–5.

    Article  Google Scholar 

  20. Campbell ML, Guzman JA. Impact of a proactive approach to improve end of life care in a medical ICU. Chest. 2003;123(1):26–71.

    Article  Google Scholar 

  21. Lautrette A, Darmon M, et al. A communication strategy and brochure for relatives of dying patients in the ICU. NEJM. 2007;356(5):469–78.

    Article  CAS  Google Scholar 

  22. Cassarett D, Packard A, et al. Do palliative consultations improve patient outcomes? J Am Geriatr Soc. 2008;56:593–9.

    Article  Google Scholar 

  23. Dionne-Odom JN, Anres A, et al. Benefits of immediate versus delayed palliative care to informal family caregivers of persons with advanced cancer: outcomes from the ENABLEIII randomized clinical trial. J Clin Oncol. 2014;32:5s. (suppl: abstr LBA9513)

    Article  Google Scholar 

  24. Morrison RS, Penrod JD, et al. Cost savings associated with US hospital palliative care programs. Arch Intern Med. 2008;168(16):1783–90.

    Article  Google Scholar 

  25. Penrod JD, Deb P, et al. Hospital-based palliative care consultation: effects on hospital cost. J Palliat Med. 2010;13(8):973–9.

    Article  Google Scholar 

  26. Morrison RS, Dietrich J, et al. Palliative care consultation teams cut hospital costs for Medicaid beneficiaries. Health Aff. 2011;30(3):454–63.

    Article  Google Scholar 

  27. McCarthy I, Philastre MR, Fine RL. Cost savings from palliative care teams and guidance for a financially viable palliative care program. Health Serv Res. 2015;50(1):217–36. https://doi.org/10.1111/1475.

    Article  PubMed  Google Scholar 

  28. Sweeney L, Halpert A, et al. Patient-centered management of complex patients can reduce costs without shortening life. Am J Manag Care. 2007;13(2):84–92.

    PubMed  Google Scholar 

  29. May P, Normand C, Cassel JB, Del Fabbro E, Fine RL, et al. Economics of Palliative Care for Hospitalized adults with serious illness: a meta-analysis. JAMA Intern Med. 2018;178:820. https://doi.org/10.1001/jamainternmed.2018.0750.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Temel JS, Greer JA, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. NEJM. 2010;363:733–42.

    Article  CAS  Google Scholar 

  31. Bakitas M, Tosteson T, et al. The Enable III randomized controlled trial of concurrent palliative oncology care. J Clin Oncol. 2014;32:5s. (suppl: abstr 9512).

    Article  Google Scholar 

  32. Ferrell BR, Temel JS, Temin S, et al. Integration of palliative care into standard oncology care: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol. 2017;35(1):96–112.

    Article  Google Scholar 

  33. Kim SH, Oh EG. Symptom experience in Korean patients with liver cirrhosis. J Pain Symptom Manag. 2006;31:326–34.

    Article  Google Scholar 

  34. Lang CA, Conrad S. Symptom prevalence and clustering of symptoms in people living with chronic Hepatitis C infection. J Pain Symptom Manag. 2006;31:335–44.

    Article  Google Scholar 

  35. Bianchi G, Marchesini G. Psychological status and depression in patients with liver cirrhosis. Dig Liver Dis. 2005;37:593–600.

    Article  CAS  Google Scholar 

  36. Diaz-Dominguez R, Perez-Bernal J. Quality of life in patients with kidney, liver, or heart failure during the waiting list period. Transplant Proc. 2006;38:2459–61.

    Article  CAS  Google Scholar 

  37. Roth K, Lynn J. Dying with end stage liver disease with cirrhosis: insights from SUPPORT. J Am Geriatr Soc. 2000;28:S122–30.

    Google Scholar 

  38. Desbiens NA, Wu AW. Pain and satisfaction with pain control in seriously ill hospitalized patients: findings from SUPPORT research investigators. Crit Care Med. 1996;24:1957–61.

    Article  Google Scholar 

  39. Arvaniti V, D’Amico G. Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology. 2010;139:1246–56.

    Article  Google Scholar 

  40. Bernacki RE, Block SD. Communication about serious illness care goals: a review and synthesis of best practices. JAMA Intern Med. 2014;174(12):1994–2003. https://doi.org/10.1001/jamainternmed.2014.5271.

    Article  PubMed  Google Scholar 

  41. Fried TR, Bradley EH, O’Leary J. Prognosis communication in serious illness: perceptions of older patients, caregivers, and clinicians. J Am Geriatr Soc. 2003;51(10):1398–403.

    Article  Google Scholar 

  42. Davison BJ, Degner LF, Morgan TR. Information and decision making preferences of men with prostate cancer. Oncol Nurs Forum. 1995;22:1401–8.

    CAS  PubMed  Google Scholar 

  43. Degner LF, Kristjanson LJ, et al. Information needs and decisional preferences in women with breast cancer. JAMA. 1997;277:1485–92.

    Article  CAS  Google Scholar 

  44. Kutner JS, Steiner JF, et al. Information needs in terminal illness. Soc Sci Med. 1999;48:1341–52.

    Article  CAS  Google Scholar 

  45. Wright AA, Zhang B, Ray A, et al. Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA. 2008;300(14):1665–73.

    Article  CAS  Google Scholar 

  46. Haggerty RG, Butow PN, et al. Communicating with realism and hope: incurable cancer patients’ views on the disclosure of prognosis. J Clin Oncol. 2005;23(6):1278–88.

    Article  Google Scholar 

  47. Block SD. Perspectives on care at the close of life: psychological considerations, growth, and transcendence at the end of life: the art of the possible. JAMA. 2001;285(22):2898–905.

    Article  CAS  Google Scholar 

  48. Shalowitz DI, Garret-Mayer E, Wendler D. The accuracy of surrogate decision makers: a systematic review. Arch Intern Med. 2006;166:493–7.

    Article  Google Scholar 

  49. Wendler D, Rid A. Systematic review: the effect on surrogates of making treatment decisions for others. Ann Intern Med. 2011;154(5):336–46.

    Article  Google Scholar 

  50. Maker AM, Sachs GA, et al. Timing of do-not-resuscitate orders for hospitalized older adults who require a surrogate decision-maker. J Am Geriatr Soc. 2011;59(7):1326–31.

    Article  Google Scholar 

  51. Narang AK, Wright AA, Nicholas LH. Trends in advance care planning in patients with cancer: results from a national longitudinal survey. JAMA Oncol. 2015;1(5):601–8. https://doi.org/10.1001/jamaoncol.2015.1976.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Rowland M, Tozer TN. Clinical pharmacokinetics and pharmacodynamics: concepts and applications. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2010.

    Google Scholar 

  53. Smith HS. Opioid metabolism. Mayo Clin Proc. 2009;84(7):613–24.

    Article  CAS  Google Scholar 

  54. Overholser BR, Foster DR. Opioid pharmacokinetic drug-drug interactions. Am J Manag Care. 2011;17:S276–87.

    PubMed  Google Scholar 

  55. Strouse TB. Pharmacokinetic drug interactions in palliative care: focus on opioids. J Palliat Med. 2009;12(11):1043–50.

    Article  Google Scholar 

  56. Rhee C, Broadbent AM. Palliation and liver failure: palliative medications dosing guidelines. J Palliat Med. 2007;10:677–85.

    Article  Google Scholar 

  57. Chochinov HM. Dying, dignity, and new horizons in palliative end-of-life care. CA Cancer J Clin. 2006;56:84–103.

    Article  Google Scholar 

  58. Chochinov HM, Hassard T, McClement S, et al. The landscape of distress in the terminally ill. J Pain Symptom Manag. 2009;38:641–9.

    Article  Google Scholar 

  59. Qiaohong G, Chochinov HM, McClement S, et al. Development and evaluation of the Dignity Talk question framework for palliative patients and their families: a mixed-methods study. Palliat Med. 2018;32(1):195–205.

    Article  Google Scholar 

  60. Cassarett D, Kutner JS, Abrahm J. End of Life Consensus Panel. Life after death: a practical approach to grief and bereavement. Ann Intern Med. 2001;134(3):208–15.

    Article  Google Scholar 

  61. Fukui N, Golabi P, Otgonsuren M, et al. Demographics, resource utilization, and outcomes of elderly patients with chronic liver disease receiving hospice care in the United States. Am J Gastroenterol. 2017;112(11):1700–8.

    Article  Google Scholar 

  62. Kim WR, Lake JR, Smith JM, et al. OPTN/SRTR 2016 Annual data report: liver. Am J Transplant. 2018;18 Suppl 1:172–253. https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajt.14559.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert L. Fine .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Fine, R.L. (2020). The Role of Palliative Care in Cirrhosis. In: Rahimi, R. (eds) The Critically Ill Cirrhotic Patient. Springer, Cham. https://doi.org/10.1007/978-3-030-24490-3_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-24490-3_16

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-24489-7

  • Online ISBN: 978-3-030-24490-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics