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Mast Cell Ontogeny

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The Mast Cell

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Abstract

Paul Ehrlich firstly described mast cells in his doctoral thesis at the Medical Faculty of Leipzig University (Crivellato et al. 2003). Ehrlich recognized two types of mast cells.

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References

  • Abonia JP, Austen KF, Rollins BJ et al (2005) Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR45. Blood 105:4308–4313

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Alcaide P, Jones TG, Lord GM et al (2007) Dendritic cell expression of the transcription factor t-bet regulates mast cell progenitor homing to mucosal tissue. J Exp Med 204:431–439

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aloe L, Levi Montalcini R (1977) Mast cells increase in tissues of neonatal rats injected with the nerve growth factor. Brain Res 133:358–366

    Article  CAS  PubMed  Google Scholar 

  • Arinobu Y, Iwasaki H, Gurish MF et al (2005) Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci USA 102:18105–18110

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ashman LK (1999) The biology of stem cell factor and its receptor C-Kit. Int J Biochem Cell Biol 31:1037–1051

    Article  CAS  PubMed  Google Scholar 

  • Babina M, SchülkeY Kirchhof L et al (2005) The transcription factor profile of human mast cells in comparison with monocytes and granulocytes. Cell Mol Life Sci 62:214–226

    Article  CAS  PubMed  Google Scholar 

  • Bellone G, Smime C, Carbone A et al (2006) KIT/stem cell factor expression in premalignant and malignant lesions of the colon mucosa in relationship to disease progression and oucomes. Int J Oncol 29:851–859

    CAS  PubMed  Google Scholar 

  • Bischoff SC, Sellge G, Lorentz A et al (1999) IL-4 enhances proliferation and mediator release in mature human mast cells. Proc Natl Acad Sci 96:8080–8085

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Boyce JA (2002) Human mast cell progenitors use alpha 4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood 99:2890–2896

    Article  CAS  PubMed  Google Scholar 

  • Butterfield JH, Weiler D, Dewald G et al (1988) Establishment of an Immature Mast Cell Line from a Patient with Mast Cell Leukemia. Leuk Res 12:345–355

    Article  CAS  PubMed  Google Scholar 

  • Cantor AB, Iwasaki H, Arinobu Y et al (2008) Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J Exp Med 205:611–624

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen CC, Grimbaldeston MA, Tsai M et al (2005) Identification of mast cell progenitors in adult mice. Proc Natl Acad Sci USA 102: 11408–11413.

    Google Scholar 

  • Costa JJ, Demetri GD, Harrist TJ et al (1996) Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. J Exp Med 183:2681–2686

    Article  CAS  PubMed  Google Scholar 

  • Crapper RM, Schrader JW (1983) Frequency of mast cell precursors in normal tissues determined by an in vitro assay: antigen induces parallel increases in the frequency of P cell precursors and mast cells. J Immunol 131:923–928

    CAS  PubMed  Google Scholar 

  • Crivellato E, Beltrami C, Mallardi F et al (2003) Paul Ehrlich’s doctoral thesis: a milestone in the study of mast cells. Br J Haematol 123:19–21

    Article  PubMed  Google Scholar 

  • Crivellato E, Nico B, Battistig M et al (2004) The thymus is a site of mast cell development in chicken embryos. Anat Embryol (Berl) 209:243–249

    Article  Google Scholar 

  • Ehrlich PLA (1898) Die Anemie, 1. Holder, Normale und Patologische Histologie des Blutes Wien

    Google Scholar 

  • Enerbäck L (1966a) Mast cells in rat gastrointestinal mucosa. I. effects of fixation. Acta Pathol Microbiol Scand 66:289–302

    Article  PubMed  Google Scholar 

  • Enerbäck L (1966b) Mast cells in rat gastrointestinal mucosa. 2. dye-binding and metachromatic properties. Acta Pathol Microbiol Scand 66:303–312

    Article  PubMed  Google Scholar 

  • Furitsu T, Saito H, Dvorak AM et al (1989) Development of human mast cells in vitro. Proc Natl Acad Sci 86:10039–10043

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Galli SJ, Kalesnikoff J, Grimbaldeston MA et al (2005a) Mast cells as “Tunable” effector and immunoregulatory cells: recent advances. Annu Rev Immunol 23:749–786

    Article  CAS  PubMed  Google Scholar 

  • Galli SJ, Nakae S, Tsai M (2005b) Mast cells in the development of adaptive immune responses. Nat Immunol 6:135–142

    Article  CAS  PubMed  Google Scholar 

  • Ginsburg H, Lagunoff D (1967) The in vitro differentiation of mast cells. Cultures of cells from immunized mouse lymph nodes and thoracic duct lymph on fibroblast monolayers. J Cell Biol 35:685–697

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grimbaldeston MA, Chen CC, Piliponski AM et al (2005) Mast cell-deficient W-sash C-kit mutant kitw-Sh/W-Sh mice as a model for investigating mast cell biology in vivo. Am J Pathol 167:835–848

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gurish MF, Austen KF (2001) The diverse role of mast cells. J Exp Med 194:F1–F5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gurish MF, Boyce JA (2006) Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell. J Allergy Clin Immunol 117:1285–1291

    Article  CAS  PubMed  Google Scholar 

  • Gurish MF, Tao H, Abonia JP et al (2001) Intestinal mast cell progenitors require CD49dbeta7 (Alpha4beta7 Integrin) for tissue-specific homing. J Exp Med 194:1243–1252

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hardy WB, Wesbrook FF (1895) The wandering cells of the alimentary canal. J Physiol 18:490–493

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang B, Lei Z, Zhang GM et al (2008) SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood 112:1269–1279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Irani AA, Schechter NM, Craig SS et al (1986) Two types of human mast cells that have distinct neutral protease compositions. Proc Natl Acad Sci USA 83:4464–4468

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Irani AM, Nilsson G, Miettinen U et al (1992) Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells. Blood 80:3009–3021

    CAS  PubMed  Google Scholar 

  • Ishizaka T, Okudaira H, Mauser LE et al (1976) Development of rat mast cells in vitro. I. Differentiation of mast cells from thymus cells. J Immunol 116:747–754

    CAS  PubMed  Google Scholar 

  • Iwasaki H, Mizuno SI, Arinobu Y et al (2006) The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev 20:3010–3021

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jolly M (1900) Clasmatocytes et mastzellen. Comp Rend Soc Biol (Paris) 52:437–455

    Google Scholar 

  • Kanbe N, Kurosawa M, Miyachi Y et al (2000) Nerve growth factor prevents apoptosis of cord blood-derived human cultured mast cells synergistically with stem cell factor. Clin Exp Allergy 30:1113–1120

    Article  CAS  PubMed  Google Scholar 

  • Kanthack AA, Hardy WB (1894) The morphology and distribution of the wandering cells of mammalia. J Physiol 17:80–119

    Article  PubMed  PubMed Central  Google Scholar 

  • Kinoshita T, Sawai N, Hidaka E et al (1999) Interleukin-6 directly modulates stem cell factor-dependent development of human mast cells derived from CD34 + cord blood cells. Blood 4:496–508

    Google Scholar 

  • Kirshenbaum AS, Kessler SW, Goff JP et al (1991) Demonstration of the origin of human mast cells from CD34 + bone marrow progenitor cells. J Immunol 146:1410–1415

    CAS  PubMed  Google Scholar 

  • Kirshenbaum AS, Goff JP, Dreskin SC et al (1989) IL-3-dependent growth of basophil-like cells and mast like cells from human bone marrow. J Immunol 149:2424–2429

    Google Scholar 

  • Kirshenbaum AS, Goff JP, Kessler SW et al (1992) Effect of IL-3 and stem cell factor on the appearance of human basophils and mast cells from CD34 + pluripotent progenitor cells. J Immunol 148:772–777

    CAS  PubMed  Google Scholar 

  • Kitamura Y, Go S (1979) Decreased production of mast cells in S1/S1d anemic mice. Blood 53:492–497

    CAS  PubMed  Google Scholar 

  • Kitamura Y, Ito A (2005) Mast cell-committed progenitors. Proc Natl Acad Sci 102:11129–11130

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kitamura Y, Shimada M, Hatanaka et al (1977) Development of mast cells from grafted bone marrow cells in irradiated mice. Nature 268: 442–443

    Article  CAS  PubMed  Google Scholar 

  • Kitamura Y, Go S, Hatanaka K (1978) Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation. Blood 52:447–452

    CAS  PubMed  Google Scholar 

  • Lantz CS, Boesiger J, Song CH et al (1998) Role for interleukin-3 In mast-cell and basophil development and in immunity to parasites. Nature 392:90–93

    Article  CAS  PubMed  Google Scholar 

  • Levi-Schaffer F, Austen KF, Gravallese PM et al (1986) Coculture of Interleukin 3-dependent mouse mast cells with fibroblasts results in a phenotypic change of the mast cells. Proc Natl Acad Sci 83:6485–6488

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Levi-Schaffer F, Austen KF, Caulfield JP et al (1987a) Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and Ige-mediated release of histamine, prostaglandin D2, and leukotrienes. J Immunol 139:494–500

    CAS  PubMed  Google Scholar 

  • Levi-Schaffer F, Dayton ET, Austen KF et al (1987b) Mouse bone marrow-derived mast cells cocultured with fibroblasts. morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. J Immunol 139:3431–3441

    CAS  PubMed  Google Scholar 

  • Lorentz A (2002) Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins. Blood 99:966–972

    Article  CAS  PubMed  Google Scholar 

  • Lorentz A, Bischoff SC (2001) Regulation of human intestinal mast cells by stem cell factor and IL-4. Immunol Rev 179:57–60

    Article  CAS  PubMed  Google Scholar 

  • Lorentz A, Hoppe J, Worthmann H et al (2007) Neurotrophin-3, but not nerve growth factor, promotes survival of human intestinal mast cells. Neurogastroenterol Motil 19:301–308

    Article  CAS  PubMed  Google Scholar 

  • Matsuda H, Kannan Y, Ushio H et al (1991) Nerve growth factor induces development of connective tissue-type mast cells in vitro from murine bone marrow cells. J Exp Med 174:7–14

    Article  CAS  PubMed  Google Scholar 

  • Matsuzawa S, Sakashita K, Kinoshita T et al (2003) IL-9 enhances the growth of human mast cell progenitors under stimulation with stem cell factor. J Immunol 170:3461–3467

    Article  CAS  PubMed  Google Scholar 

  • Mitsui H, Furitsu T, Dvorak AM et al (1993) Development of human mast cells from umbilical cord blood cells by recombinant human and murine c-kit ligand. Proc Natl Acad Sci 90:735–739

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moller C, Alfredsson J, Engström M et al (2005) Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim. Blood 106:1330–1336

    Article  PubMed  Google Scholar 

  • Nagao K, Yokoro K, Aaronson S (1981) Continuous lines of basophil/mast cells derived from normal mouse bone marrow. Science 212:333–335

    Article  CAS  PubMed  Google Scholar 

  • Nakano T, Sonoda T, Hayashi C, et al (1985) Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice: evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J Exp Med 162:1025–1043

    Article  CAS  PubMed  Google Scholar 

  • Nishiyama C (2005) GATA-1 Is Required for Expression of Fc RI on Mast Cells: Analysis of Mast Cells Derived from GATA-1 Knockdown Mouse Bone Marrow. Int Immunol 17:847–856

    Article  CAS  PubMed  Google Scholar 

  • Ochi H, Hirani WM, Yuan Q et al (1999) T helper cell type 2 cytokine-mediated comitogenic responses and Ccr3 expression during differentiation of human mast cells in vitro. J Exp Med 190:267–280

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Okayama Y, Kawakami T (2006) Development, migration and survival of mast cells. Immunol Res 34:97–115

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pittoni P, Tripodo C, Piconese S et al (2011) Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers. Cancer Res 71:5987–5997

    Article  CAS  PubMed  Google Scholar 

  • Rodewald HR, Dessing M, Dvorak AM et al (1996) Identification of a committed precursor for the mast cell lineage. Science 271:818–822

    Article  CAS  PubMed  Google Scholar 

  • Rubin BP, Heinrich MC, Corless CL (2007) Gastrointestinal stromal tumour. Lancet 369:1731–1734

    Article  CAS  PubMed  Google Scholar 

  • Saito H (2006) Culture of human mast cells from hemopoietic progenitors. Methods Mol Biol 315:113–122

    PubMed  Google Scholar 

  • Sakata-Yanagimoto M, Sakai T, Miyake Y et al (2011) Notch 2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine. Blood 117:128–134

    Article  CAS  PubMed  Google Scholar 

  • Taghon T, Yui MA, Rothenberg EV (2007) Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3. Nat Immunol 8:845–855

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tam SY, Tsai M, Yamaguchi M et al (1997) Expression of functional trka receptor tyrosine kinase in the HMC-1 human mast cell line and in human mast cells. Blood 90:1807–1820

    CAS  PubMed  Google Scholar 

  • Tei H, Kasugai T, Tsuijimura T et al (1994) Characterization of cultured mast cells derived from Ws/Ws mast cell-deficient rats with a small deletion at tyrosine kinase domain of c-kit. Blood 83:913–925

    Google Scholar 

  • Tsai M (1991) The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. analysis by anatomical distribution, histochemistry, and protease phenotype. J Exp Med 174:125–131

    Article  CAS  PubMed  Google Scholar 

  • Valent P, Spanblochl E, Sperr WR et al (1992) Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor/kit-ligand in long-term culture. Blood 80:2237–2245

    CAS  PubMed  Google Scholar 

  • Valent P, Akin C, Sperr WR et al (2005) Mastocytosis: pathology, genetics and current options for therapy. Leuk Lymph 46:35–48

    Article  CAS  Google Scholar 

  • Williams HU (1900) A critical summary of recent literature on plasma-cells and mast cells. Am J Med Sci 119:702–709

    Article  Google Scholar 

  • Winandy S, Brown M (2007) No DL1 notch ligand? GATA Be a mast cell. Nat Immunol 8:796–797

    Article  CAS  PubMed  Google Scholar 

  • Zhang W, Stoica G, Tasca SI et al (2000) Modulation of tumor angiogenesis by stem cell factor. Cancer Res 60:6757–6762

    CAS  PubMed  Google Scholar 

  • Zhou JS, Xing W, Friend DS et al (2007) Mast cell deficiency in Kit(W-Sh) mice does not impair antibody-mediated arthritis. J Exp Med 204:2797–2802

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  1. Department of Biomedical Sciences, Neurosciences and Sensory Organs, University of Bari, Bari, Italy

    Domenico Ribatti

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Ribatti, D. (2019). Mast Cell Ontogeny. In: The Mast Cell . Springer, Cham. https://doi.org/10.1007/978-3-030-24190-2_2

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