Abstract
Combined heart-lung transplantation (HLTx) is a surgical treatment for highly specific patients with advanced cardiopulmonary failure. Although the rates of patients undergoing HLTx have decreased over time, a few select centers continue to offer the procedure. Current indications include Eisenmenger syndrome with an uncorrected intracardiac defect, uncorrectable congenital heart disease with atresia or diffuse severe hypoplasia of the pulmonary arteries, and coexistent severe cardiopulmonary disease with advanced heart or lung failure. This chapter will outline aspects of thoracic transplantation that are specific to HLTx.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Chambers DC, Yusen RD, Cherikh WS, Goldfarb SB, Kucheryavaya AY, Khusch K, Levvey BJ, Lund LH, Meiser B, Rossano JW, Stehlik J. International Society for Heart and Lung Transplantation. The Registry of the International Society for Heart and Lung Transplantation: thirty-fourth adult lung and heart-lung transplantation report-2017; Focus theme: allograft ischemic time. J Heart Lung Transplant. 2017;36:1047–59.
de Perrot M, Granton JT, McRae K, Pierre AF, Singer LG, Waddell TK, Keshavjee S. Outcome of patients with pulmonary arterial hypertension referred for lung transplantation: a 14-year single-center experience. J Thorac Cardiovasc Surg. 2012;143:910–8.
Fadel E, Mercier O, Mussot S, Leroy-Ladurie F, Cerrina J, Chapelier A, Simonneau G, Dartevelle P. Long-term outcome of double-lung and heart-lung transplantation for pulmonary hypertension: a comparative retrospective study of 219 patients. Eur J Cardiothorac Surg. 2010;38:277–84.
Carrel A. Johns Hopkins Hosp Bull. 1907;18:18–28.
Demikhov VP. Experimental transplantation of vital organs. New York City: Consultants Bureau Enterprises, Inc.; 1962. American Edition translated from the 1960 Russian Edition by Basil Haigh, M.A., M.B., B.Chir.
Webb WR, Howard HS. Cardio-pulmonary transplantation. Surg Forum. 1957;8:313–7.
Longmore DB, Cooper DK, Hall RW, Sekabunga J, Welch W. Transplantation of the heart and both lungs. II. Experimental cardiopulmonary transplantation. Thorax. 1969;24:391–8.
Grinnan GL, Graham WH, Childs JW, Lower RR. Cardiopulmonary homotransplantation. J Thorac Cardiovasc Surg. 1970;60:609–15.
Nakae S, Webb WR, Theodorides T, Sugg WL. Respiratory function following cardiopulmonary denervation in dog, cat, and monkey. Surg Gynecol Obstet. 1967;125:1285–92.
Cooley DA, Bloodwell RD, Hallman GL, Nora JJ, Harrison GM, Leachman RD. Organ transplantation for advanced cardiopulmonary disease. Ann Thorac Surg. 1969;8:30–46.
Wildevuur CR, Benfield JR. A review of 23 human lung transplantations by 20 surgeons. Ann Thorac Surg. 1970;9:489–515.
Losman JG, Campbell CD, Replogle RL, Barnard CN. Joint transplantation of the heart and lungs. Past experience and present potentials. J Cardiovasc Surg (Torino). 1982;23:440–52.
Reitz BA, Wallwork JL, Hunt SA, Pennock JL, Billingham ME, Oyer PE, Stinson EB, Shumway NE. Heart-lung transplantation: successful therapy for patients with pulmonary vascular disease. N Engl J Med. 1982;306:557–64.
Kirklin JK, Young JB, McGiffin DC. Heart transplantation. Philadelphia, PA: Churchill Livingstone; 2002.
Hopkins WE. The remarkable right ventricle of patients with Eisenmenger syndrome. Coron Artery Dis. 2005;16:19–25.
Niwa K, Perloff JK, Kaplan S, Child JS, Miner PD. Eisenmenger syndrome in adults: ventricular septal defect, truncus arteriosus, univentricular heart. J Am Coll Cardiol. 1999;34:223–32.
Saha A, Balakrishnan KG, Jaiswal PK, Venkitachalam CG, Tharakan J, Titus T, et al. Prognosis for patients with Eisenmenger syndrome of various aetiology. Int J Cardiol. 1994;45:199–207.
Hopkins WE, Ochoa LL, Richardson GW, Trulock EP. Comparison of the hemodynamics and survival of adults with severe primary pulmonary hypertension or Eisenmenger syndrome. J Heart Lung Transplant. 1996;15:100–5.
D’Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med. 1991;115:343–9.
Fuster V, Steele PM, Edwards WD, Gersh BJ, McGoon MD, Frye RL. Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation. 1984;70:580–7.
Riedel M, Stanek V, Widimsky J, Prerovsky I. Long-term follow-up of patients with pulmonary thromboembolism. Late prognosis and evolution of hemodynamic and respiratory data. Chest. 1982;81:151–8.
Robalino BD, Moodie DS. Association between primary pulmonary hypertension and portal hypertension: analysis of its pathophysiology and clinical, laboratory and hemodynamic manifestations. J Am Coll Cardiol. 1991;17:492–8.
Weill D, Benden C, Corris PA, Dark JH, Davis RD, Keshavjee S, Lederer DJ, Mulligan MJ, Patterson GA, Singer LG, Snell GI, Verleden GM, Zamora MR, Glanville AR. A consensus document for the selection of lung transplant candidates: 2014--an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2015;34:1–15.
Lick SD, Copeland JG, Rosado LJ, Arabia FA, Sethi GK. Simplified technique of heart-lung transplantation. Ann Thorac Surg. 1995;59:1592–3.
Pinderski LJ, Kirklin JK, McGiffin D, Brown R, Naftel DC, Young KR Jr, Smith K, Bourge RC, Tallaj JA, Rayburn BK, Benza R, Zorn G, Leon K, Wille K, Deierhoi M, George JF. Multi-organ transplantation: is there a protective effect against acute and chronic rejection? J Heart Lung Transplant. 2005;24:1828–33.
Date H, Trulock EP, Arcidi JM, Sundaresan S, Cooper JD, Patterson GA. Improved airway healing after lung transplantation. An analysis of 348 bronchial anastomoses. J Thorac Cardiovasc Surg. 1995;110:1424–33.
Griffith BP, Magee MJ, Gonzalez IF, Houel R, Armitage JM, Hardesty RL, Hattler BG, Ferson PF, Landreneau RJ, Keenan RJ. Anastomotic pitfalls in lung transplantation. J Thorac Cardiovasc Surg. 1994;107:743–54.
Schafers HJ, Haydock DA, Cooper JD. The prevalence and management of bronchial anastomotic complications in lung transplantation. J Thorac Cardiovasc Surg. 1991;101:1044–52.
Shumway SJ, Hertz MI, Maynard R, Kshettry VR, Bolman RM III. Airway complications after lung and heart-lung transplantation. Transplant Proc. 1993;25:1165–6.
Tamm M, Wallwork J, Higenbottam T. Heart-lung transplantation: results. In: Patterson GA, Couraud L, editors. Lung transplantation, vol. 3. Amsterdam: Elsevier Science; 1995. p. 399–423.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Hayes, D., Mulvihill, M.S., McGiffin, D. (2020). Heart-Lung Transplantation. In: Raja, S. (eds) Cardiac Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-24174-2_71
Download citation
DOI: https://doi.org/10.1007/978-3-030-24174-2_71
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-24173-5
Online ISBN: 978-3-030-24174-2
eBook Packages: MedicineMedicine (R0)