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Gastrointestinal, Pancreas, and Bile Ducts Cytology

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Practical Cytopathology

Part of the book series: Practical Anatomic Pathology ((PAP))

Abstract

In this chapter, we are focusing on gastrointestinal tract, pancreas, and bile ducts cytology. The conventional cytology sampling methods in GI and pancreaticobiliary tract are brushing, which is an easy and quick way to diagnose most of the mucosal-based disease. With the advent of new diagnostic tools, such as endoscopic ultrasound-directed fine-needle aspirates (EUS-FNA), submucosal-based mass lesions and regional lymph nodes are readily accessible by minimal invasive cytology method nowadays. Pancreatic cancer is one of the leading causes of death in Western Country. The cytological samples for pancreatic lesions include CT or EUS-guided fine-needle aspiration (FNA) and pancreatic or common bile duct brushing. However, EUS-FNA is more commonly performed now. Here we discuss commonly encountered questions in GI and pancreaticobiliary cytology practice and encompass the whole spectrum of morphologic findings from normal elements, reactive conditions, infectious lesions, and neoplasms. Common differential diagnoses, immunohistochemistry applications, and diagnostic pitfalls are emphasized. The updated knowledge on biomarker testing in pancreatic cancer is reviewed. Six illustrative cases are presented with take-home messages from each case.

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Author information

Authors and Affiliations

  1. Department of Pathology and Immunology, Washington University, St. Louis, MO, USA

    Zhongren Zhou

  2. Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA

    Cory T. Bernadt

  3. Boston VA Health Care System and Boston University Medical School, Boston, MA, USA

    Huihong Xu

Authors
  1. Zhongren Zhou
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  2. Cory T. Bernadt
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  3. Huihong Xu
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Corresponding author

Correspondence to Huihong Xu .

Editor information

Editors and Affiliations

  1. VA Boston Healthcare System, Boston, MA, USA

    Huihong Xu

  2. Brigham and Women’s Hospital, Boston, MA, USA

    Xiaohua Qian

  3. Robert Wood Johnson University Hospital, New Brunswick, NJ, USA

    He Wang

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Zhou, Z., Bernadt, C.T., Xu, H. (2020). Gastrointestinal, Pancreas, and Bile Ducts Cytology. In: Xu, H., Qian, X., Wang, H. (eds) Practical Cytopathology . Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-24059-2_6

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  • DOI: https://doi.org/10.1007/978-3-030-24059-2_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-24058-5

  • Online ISBN: 978-3-030-24059-2

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