Abstract
Skin decontamination, an important step mitigating percutaneous absorption through the stratum corneum (SC), is a highly complex process. Thus, understanding diffusion mechanisms and measuring dermal absorption rates are critical to protect humans from toxic exposures. Here, highly varied literature is placed in a biological and clinical perspective in regards to decontamination. Recent data have shown multiple layers of SC structural heterogeneity, which result in unique substance partitioning characteristics across the membrane. As such, attempts to model and understand this behavior in alternative in vitro membranes prove difficult. More synthetic and natural membranes are being explored as models for vivo behavior. In addition, commonly accepted decontamination methods are undergoing risk assessment. These recent and varied literature findings update available knowledge regarding skin decontamination and its challenges.
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Phuong, C., Maibach, H.I. (2020). Recent Knowledge: Human/Animal Skin Decontamination. In: Zhu, H., Maibach, H. (eds) Skin Decontamination. Springer, Cham. https://doi.org/10.1007/978-3-030-24009-7_3
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DOI: https://doi.org/10.1007/978-3-030-24009-7_3
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