Stem Cell Therapy for Multiple Sclerosis: An Exciting Challenge or a Treatment Hope

  • Fakher Rahim
  • Kiarash Shirbandi
  • Rasoul Akbari
Part of the Stem Cells in Clinical Applications book series (SCCA)


Multiple sclerosis (MS) is an autoimmune inflammatory disease in which release of various cytokines, such as tumor necrosis factor-α (TNFα) and interferon gamma (IFNγ), can damage myelin, oligodendrocytes, and axons in the central nervous system (CNS). Like other degenerative diseases of CNS, MS treatment is only symptomatic and scientists are looking for a way to replace it with cell therapy. The stem cells are non-differentiated cells that can maintain the proliferation and production of precursor cells; thus, in response to specific stimuli, can be differentiated into the types of cells present in the body. Since researchers started treating patients with MS many years ago, some of the results are quite miraculous; they have seen deep nervous improvement in these patients. However, more research is needed to prove that MS patients experience only an interim improvement that sometimes happens in this disease. Recent research suggests and hopes that stem cell therapy will develop and propose a new and safe treatment approach to various diseases, especially neurodegenerative disorders such as MS in the near future. However, despite these impressive improvements, the treatment is not suitable for all patients. The results of a recent trial showed that this method only helped to improve the symptoms of approximately half the enrolled patients. Besides, there are also concerns about the potential for developing lethal diseases.


Efficacy Stem cell Multiple sclerosis Transplantation Toxicity 


Conflict of Interest

The authors declare that they have no conflict of interest.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Fakher Rahim
    • 1
    • 2
  • Kiarash Shirbandi
    • 3
  • Rasoul Akbari
    • 4
  1. 1.Research Center of Thalassemia & Hemoglobinopathies, Health Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran
  2. 2.Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular - Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  3. 3.Systematic Review and Meta-analysis Expert Group (SRMEG)Universal Scientific Education and Research Network (USERN)TehranIran
  4. 4.Department of Clinical Biochemistry, Allied Health Sciences SchoolAhvaz Jundishapur University of Medical SciencesAhvazIran

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