Abstract
Centrosome amplification is a feature of multiple tumour types and has been postulated to contribute to both tumour initiation and tumour progression. This chapter focuses on the mechanisms by which an increase in centrosome number might lead to an increase or decrease in tumour progression and the role of proteins that regulate centrosome number in driving tumorigenesis.
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Abbreviations
- AKAP450:
-
A-kinase-anchoring protein 450
- cdc25C:
-
Cell division cycle 25C
- CDK:
-
Cyclin-dependent kinase
- CDK5RAP2:
-
CDK5 regulatory Subunit-associated protein 2
- CENP-E:
-
CENtrosome-associated Protein E
- Cep:
-
Centrosomal protein
- CLIP-70:
-
Cytoplasmic LInker Protein 170
- C-NAP1:
-
Centrosomal Nek2-associated Protein 1
- CP110:
-
Centriolar coiled-coil Protein of 110 kDa
- CPAP:
-
Centrosomal P4.1-associated Protein
- EGFR:
-
Epidermal growth factor receptor
- FBF1:
-
Fas-binding factor 1
- GCP:
-
γ-tubulin complex protein
- hPOC5:
-
human Proteome of Centriole 5
- INCENP:
-
Inner CENtromere Protein
- LRRC45:
-
Leucine-rich repeat containing 45
- NEDD1:
-
Neural precursor cell expressed developmentally down-regulated protein 1
- ODF2:
-
Outer dense fiber protein 2
- SAS-6:
-
Spindle assembly abnormal protein 6
- SCLT1:
-
Sodium channel and clathrin linker 1
- SMC3:
-
Structural maintenance of chromosomes protein 3
- STIL:
-
SCL interrupting locus protein
- TACC2:
-
Transforming acidic coiled-coil-containing protein 2
- TRF1:
-
Telomeric repeat-binding factor 1
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Bose, A., Dalal, S.N. (2019). Centrosome Amplification and Tumorigenesis: Cause or Effect?. In: Kloc, M. (eds) The Golgi Apparatus and Centriole. Results and Problems in Cell Differentiation, vol 67. Springer, Cham. https://doi.org/10.1007/978-3-030-23173-6_18
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