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Heat Shock Protein 90 in Kidney Stone Disease

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Heat Shock Protein 90 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 19))

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Abstract

Since early 2000s, proteomics has been applied to kidney stone research by its capability to uncover the previously unexplored or unknown proteins that are involved in kidney stone pathogenesis but had been previously hidden by the limitation of tools for protein science in the past. Using proteomics approach, several novel findings have been generated and a list of proteins involved in kidney stone formation or development has been expanded tremendously. One of such proteins is heat shock protein 90 (HSP90), which is generally known as a molecular chaperone. Its common roles are stress response and regulation of folding and conformation of many other proteins. However, new findings from recent proteomics studies have shown that HSP90 is also involved in kidney stone formation and disease mechanisms as summarized and discussed in this chapter.

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Abbreviations

AP-MS:

Affinity purification followed by mass spectrometry

COM:

Calcium oxalate monohydrate

ECM:

Extracellular matrix

HSP90:

Heat shock protein 90

IFN-α:

Interferon-α

IL-6:

Interleukin-6

MCP-1:

Monocyte chemoattractant protein-1

MS:

Mass spectrometry

MS/MS:

Tandem MS

Q-TOF:

Quadrupole time-of-flight

siHSP90:

Small interfering RNA targeting to HSP90

siRNA:

Small interfering RNA

TAP:

Tandem affinity purification

TNF-α:

Tumor necrosis factor-α

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Acknowledgements

This work was supported by Mahidol University research grant and the Thailand Research Fund (IRN60W0004 and IRG5980006).

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Authors and Affiliations

  1. Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Visith Thongboonkerd

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  1. Visith Thongboonkerd
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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Thongboonkerd, V. (2019). Heat Shock Protein 90 in Kidney Stone Disease. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-030-23158-3_26

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