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Heat Shock Protein 60 in Human Diseases and Disorders pp 57–68Cite as

Utilizing the Unique Architecture and Abilities of HSP60 in Drug Development

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Part of the book series: Heat Shock Proteins ((HESP,volume 18))

Abstract

As a major active component in the maintenance of protein homeostasis, the HSP60 family of proteins have evolved numerous unique abilities that are useful in detecting, stabilizing, and facilitating the recovery of various proteins that have denatured under stress. From a technological viewpoint, many of the unique abilities of HSP60 may potentially be used to solve a variety of problems in drug development, as well as to serve as a scaffold for various applications that are relevant to the medical field. This section is an overview of recent efforts to harness the unique abilities of the HSP60 proteins in its role as a chaperonin, capable of preventing the aggregation of and stimulating the recovery of various proteins that have undergone stress-related denaturation.

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Abbreviations

AD:

Apical domain

CCT:

Chaperonin containing T-complex polypeptide 1

GroEL-AD:

The isolated apical domain of GroEL

HSP:

Heat shock protein

PolyQ:

Polyglutamine

TRiC:

T-complex polypeptide 1 ring complex

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Acknowledgements

The authors were funded by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED (JP18dm0107073).

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Authors and Affiliations

  1. Faculty of Engineering and Center for Research on Green Sustainable Chemistry, Tottori University, Tottori, Japan

    Tomohiro Mizobata & Yasushi Kawata

Authors
  1. Tomohiro Mizobata
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  2. Yasushi Kawata
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Corresponding authors

Correspondence to Tomohiro Mizobata or Yasushi Kawata .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Mizobata, T., Kawata, Y. (2019). Utilizing the Unique Architecture and Abilities of HSP60 in Drug Development. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 60 in Human Diseases and Disorders. Heat Shock Proteins, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-23154-5_5

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