Abstract
The continued significant societal challenge of both civilian and military traumatic brain injury (TBI) makes the development of preventive strategies ranging from primary to secondary to tertiary pressing. The invisible and visible loss of societal productivity further underscores this urgency. The clinical complexity of traumatic brain has resulted in controversy, especially in the appreciation of concussion and its sequelae with the need to clearly define terms such as mild TBI and the persistent post-concussive syndrome or symptom complex. The following overview highlights some of the key areas of the required interdisciplinary approach to TBI.
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Walshe T. Neurological concepts in Archaic Greece: what did Homer know. J Hist Neurosci. 1997;6(1):72–81.
Sablas D. Functional neuroanatomy in the pre-Hippocratic era: observations from the Iliad of Homer. Neurosurgery. 2001;48(6):1352–7.
McCory P, Berkovic SF. Concussion: the history of clinical and pathophysiological concepts and misconceptions. Neurology. 2001;57:2283–9.
Kors E, Terwindt G, Vermeulen F, Fitzsimons R, Jardine P, Heywood P, et al. Delayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine. Ann Neurol. 2001;49:753–60.
Schiffmann R, Elroy-Stein O. Childhood ataxia with CNS hypomyelination/vanishing white matter disease—a common leukodystrophy caused by abnormal control of protein synthesis. Mol Genet Metab. 2006;88:7–15.
Visible human project. http://www.nlm.nih.gov/research/visible/visible_human.html.
Saatman K, Duhaime AC, Bullock R, Maas AI, Valadka A, Manley GT, et al. Classification of traumatic brain injury for targeted therapies. J Neurotrauma. 2008;25(7):719–38.
Wright D, Kellermann AL, Hertzberg VS, Clark PL, Frankel M, Goldstein FC, et al. ProTect: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann Emerg Med. 2007;49:391–402.
Beauchamp K, Mutlak H, Smith WR, Shohami E, Stahel PF. Pharmacology of traumatic brain injury: where is the “golden bullet”? Mol Med. 2008;14:731–40.
Xiao G, Wei J, Yan W, Wang W, Lu Z. Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit Care. 2008;12:R61.
Stein DG. Embracing failure: what the phase III progesterone studies can teach about TBI clinical trials. Brain Inj. 2015;29(11):1259–72.
Finkelstein E, Corso P, Miller T. The incidence and economic burden of injuries in the United States. New York: Oxford University Press; 2006.
Faul M, Xu L, Wald MM, Coronado VG. Traumatic brain injury in the United States: emergency department visits, hospitalizations, and deaths. Atlanta: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control; 2010.
Zasler N, Katz DI, Zafonte RD. Brain injury medicine. New York: Demos Medical Publishing; 2007.
Shaw N. The neurophysiology of concussion. Prog Neurobiol. 2002;67:281–344.
Henry L, Tremblay S, Boulanger Ellenberg D, Lassonde M. Neurometabolic changes in the acute phase after sports concussion correlate with symptom severity. J Neurotrauma. 2010;27:65–75.
Casson I, Pellman EJ, Viano DC. Concussion in the national football league: an overview for neurologists. Neurol Clin. 2008;26:217–41.
Denny-Brown D, Ritchie Russell W. Experimental cerebral concussion. J Physiol. 1940;99:153.
Holbourn A. Mechanics of head injury. Lancet. 1943;2:438–41.
Gurdjian ES, Lissner HR. Mechanism of head injury as studied by the cathode ray oscilloscope, preliminary report. J Neurosurg. 1944;1:393–9.
Ivancevic V. New mechanics of traumatic brain injury. Cogn Neurodyn. 2009;3:281–93.
Biot M. Acoustics, elasticity, and thermodynamics of porous media - twenty-one papers by M. A. Biot. Woodbury: Acoustical Society of America; 1992.
Coussy O. PoroMechanics. Chichester, John Wiley & Sons; 2004.
Oda J, Sakamoto J, Sakano K. Mechanical evaluation of the skeletal structure and tissue of the woodpecker and its shock absorbing system. JSME Int J. 2006;40(3):390–6.
Mckee AC, Stein TD, Kiernan PT, Alvarez VE. The neuropathology of chronic traumatic encephalopathy. Brain Pathol. 2015;25(3):350–64.
Farah G, Siwek D, Cummings P, Planel E. Tau accumulations in the brains of woodpeckers. PLoS One. 2018;13(2):e0191526.
Cicerone K, Kalmar K. Persistent postconcussion syndrome: the structure of subjective complaints after mild traumatic brain injury. J Head Trauma Rehabil. 1995;10:1–7.
Ropper A, Gorson KC. Concussion. NEJM. 2007;356(2):166–72.
Whittaker R, Kemp S, House A. Illness perceptions and outcome in mild head injury: a longitudinal study. J Neurol Neurosurg Psychiatry. 2007;78:644–6.
Wood R. Post concussional syndrome: all in the mind’s eye! J Neurol Neurosurg Psychiatry. 2007;78:552.
Niogi S, Mukerjee P, Ghajar J, Johnson C, Kolster RA, Sarkar R, et al. Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T diffusion tensor imaging study of mild traumatic brain injury. AJNR. 2008;29:967–73.
Saraf H, Ramesh KT, Lennon AM, Merkle AC, Roberts IC. Mechanical properties of soft human tissues under dynamic loading. J Biomech. 2007;40:1960–7.
Gennarelli T, Thibault L, Graham D. Diffuse axonal injury: an important form of traumatic brain damage. Neuroscientist. 1998;4:202–15.
Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review. NMR Biomed. 2002;15:435–55.
Lee J, Choi CG, Chun MH. Usefulness of diffusion tensor imaging for evaluation of motor function in patients with traumatic brain Injury. J Head Trauma Rehabil. 2006;21:272–8.
Bazarian J, Zhong J, Blyth B, Zhu T, Kavcic V, Peterson D. Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot study. J Neurotrauma. 2007;24:1447–59.
Budde M, Kim JH, Liang HF, Schmidt RE, Russell JH, Cross AH, et al. Toward accurate diagnosis of white matter pathology using diffusion tensor imaging. Magn Reson Med. 2007;57:686–95.
Kraus M, Susmaras T, Caughlin BP, Walker CJ, Sweeney JA, Little DM. White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain. 2007;130:2508–19.
MacDonald C, Dikranian K, Bayly P, Holtzman D, Brody D. Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury. J Neurosci. 2007;51:11869–76.
Mori S. Introduction to diffusion tensor imaging. Amsterdam: Elsevier; 2007.
Neil J. Diffusion imaging concepts for clinicians. J Magn Reson Imaging. 2008;27:1–7.
Rutgers D, Filliard P, Paradot G, Tadie M, Lasjaunais P, Ducreux D. Diffusion tensor imaging characteristics of the corpus callosum in mild moderate and severe traumatic brain injury. AJNR. 2008;29:1730–5.
Rutgers D, Toulgoat F, Cazejust J, Filliard P, Lasjaunais P, Ducreux D. White matter abnormalities in mild traumatic brain Injury: a diffusion tensor imaging study. AJNR. 2008;29:514–9.
Wilde E, McCauley SR, Hunter JN, Bigler ED, Chu Z, Wang ZJ, et al. Diffusion tensor imaging of acute mild traumatic brain injury in adolescents. Neurology. 2008;70:948–55.
Budde M, Xie M, Cross AH, Song SK. Axial diffusivity is the primary correlate of axonal Injury in experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci. 2009;29:2805–13.
Bendlin B, Ries ML, Lazar M, Alexander AL, Dempsey RJ, Rowley HA, et al. Longitudinal changes in patients with traumatic brain injury assessed with diffusion tensor imaging. NeuroImage. 2008;42:503–14.
Lord Southborough and Committee. Report of the War Office Committee of Enquiry into Shell-shock. Military Handbook Series. Crawley: Imperial War Museum; 1922.
Moore D, Radovitzky RA, Shupenko L, Klinoff A, Jaffee MS, Rosen JM. Blast physics and central nervous system injury. Future Neurol. 2008;3:243–50.
Mayorga M. The pathology of primary blast overpressure injury. Toxicology. 2007;121:17–28.
Guy R, Kirkman E, Watkins PE, Cooper GJ. Physiologic responses to primary blast. J Trauma. 1998;45:983–7.
Guy R, Glover MA, Cripps NP. Primary blast injury: pathophysiology and implications for treatment. Part III: injury to the central nervous system and the limbs. J R Nav Med Serv. 2000;86:27–31.
DePalma R, Burris DG, Champion HR, Hodgson MJ. Blast injury. N Engl J Med. 2005;353:1335–42.
Warden D, French LM, Shupenko L, Fargus J, Riedy G, Erickson ME, et al. Case report of a soldier with primary blast brain injury. NeuroImage. 2009;47:T152–3.
Moore D, Jérusalem A, Nyein M, Noels L, Jaffee MS, Radovitzky RA. Computational biology - modeling of primary blast effects on the central nervous system. NeuroImage. 2009;47:T10–20.
Nyein MK, Jason AM, Yu L, Pitaa CM, Joannopoulos JD, Moore DF, et al. In silico investigation of intracranial blast mitigation with relevance to military traumatic brain injury. PNAS. 2010;107(48):20703–8.
Jeana A, Nyeina MK, Zheng JQ, Moore DF, Joannopoulos JD, Radovitzky R. An animal-to-human scaling law for blast-induced traumatic brain injury risk assessment. PNAS. 2014;111(43):15310–5.
Armonda R, Bell RS, Vo AH, Ling G, DeGraba TJ, Crandall B, et al. Wartime traumatic cerebral vasospasm: recent review of combat casualties. Neurosurgery. 2006;59(6):1215.
Hoge C, Goldberg HM, Castro CA. Care of war veterans with mild traumatic brain Injury -flawed perspectives. N Engl J Med. 2008;360:1588–91.
Hoge C, McGurk D, Thomas JL, Cox AL, Engel CC, Castro CA. Mild traumatic brain injury in U.S. soldiers returning from Iraq. N Engl J Med. 2008;358:453–63.
Acknowledgments
This work was support in full by financial aid from the Defense and Veterans Brain Injury Center, the Joint Improvised Explosive Device Defeat Organization (JIEDDO), and the Army Research Office. The authors appreciate the permission of Dr. James Smirniotopoulos, Radiology, USUHS, and Dr. Gerard Riedy, Radiology, WRAMC, for the use of the neuroimaging slide in Fig. 6. We also thank Dr. Simona Socrates for the use of Fig. 3.
Conflict of Interest Statement
The authors have no conflicts of interest to disclose. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of the Army, Department of Defense, or US Government.
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Moore, D.F., Jaffee, M., Ling, G., Radovitzky, R. (2020). Overview of Traumatic Brain Injury (TBI). In: Tsao, J. (eds) Traumatic Brain Injury. Springer, Cham. https://doi.org/10.1007/978-3-030-22436-3_1
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DOI: https://doi.org/10.1007/978-3-030-22436-3_1
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