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Pancreatic Ductal Adenocarcinoma and Its Variants

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Pancreas and Biliary Tract Cytohistology

Part of the book series: Essentials in Cytopathology ((EICP,volume 28))

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Abstract

Pancreatic ductal adenocarcinoma (PDCA) represents the most common primary pancreatic malignancy, with patients presenting with a variety of nonspecific abdominal symptoms. Radiographic studies, which include a combination of computed tomography and magnetic resonance imaging, are useful for characterizing the lesion and for staging purposes. However, endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is necessary for diagnosis. In addition to the conventional type of pancreatic ductal adenocarcinoma, there are a diverse group of histologic variants. However, with the exception of colloid carcinoma, the remaining types of ductal adenocarcinoma carry a grim prognosis. An understanding of the cytomorphologic and histologic features of conventional type of ductal adenocarcinoma and the variants is important to ensure accurate diagnoses, as certain variants can have significant prognostic implications. Ancillary studies, including immunohistochemistry and molecular testing, may be useful adjuncts in distinguishing between variants.

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  1. Department of Pathology and Laboratory Medicine, Weill-Cornell Medicine, New York Presbyterian Hospital, New York, NY, USA

    Kartik Viswanathan & Rema Rao

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  1. Kartik Viswanathan
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  2. Rema Rao
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  1. Department of Pathology and Laboratory Medicine, Weill-Cornell Medicine, NewYork Presbyterian Hospital, New York, NY, USA

    Abha Goyal

  2. Department of Pathology and Laboratory Medicine, Weill-Cornell Medicine, NewYork Presbyterian Hospital, New York, NY, USA

    Rema Rao

  3. Department of Pathology and Laboratory Medicine, Weill-Cornell Medicine, New York Presbyterian Hospital, New York, NY, USA

    Momin T. Siddiqui

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Viswanathan, K., Rao, R. (2019). Pancreatic Ductal Adenocarcinoma and Its Variants. In: Goyal, A., Rao, R., Siddiqui, M. (eds) Pancreas and Biliary Tract Cytohistology. Essentials in Cytopathology, vol 28. Springer, Cham. https://doi.org/10.1007/978-3-030-22433-2_5

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