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Cytokine Storm Syndrome pp 319–330Cite as

Zoonotic Bacterial Infections Triggering Cytokine Storm Syndrome

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Abstract

Zoonotic infections can result in life-threatening complications that can manifest with hemophagocytic lymphohistiocytosis (HLH)/cytokine storm syndrome (CSS). Zoonotic bacterial infections constitute the largest group of reported cases associated with HLH among other zoonotic infections. There is a growing list of zoonotic bacterial infections associated with HLH/CSS and these include Brucella spp., Rickettsia spp., Ehrlichia, Coxiella burnetii, and Mycobacterium spp.

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References

  1. Cascio, A., Pernice, L. M., Barberi, G., Delfino, D., Biondo, C., Beninati, C., et al. (2012). Secondary hemophagocytic lymphohistiocytosis in zoonoses. A systematic review. European Review for Medical and Pharmacological Sciences, 16, 1324–1337.

    CAS  PubMed  Google Scholar 

  2. Lecronier, M., Prendki, V., Gerin, M., Schneerson, M., Renvoisé, A., Larroche, C., et al. (2013). Q fever and Mediterranean spotted fever associated with hemophagocytic syndrome: Case study and literature review. International Journal of Infectious Diseases, 17, e629–e633.

    Article  CAS  PubMed  Google Scholar 

  3. Otrock, Z. K., Gonzalez, M. D., & Eby, C. S. (2015). Ehrlichia-induced hemophagocytic lymphohistiocytosis: A case series and review of literature. Blood Cells, Molecules & Diseases, 55, 191–193.

    Article  Google Scholar 

  4. Pappas, G., Papadimitriou, P., Akritidis, N., Christou, L., & Tsianos, E. V. (2006). The new global map of human brucellosis. The Lancet Infectious Diseases, 6, 91–99.

    Article  PubMed  Google Scholar 

  5. Dean, A. S., Crump, L., Greter, H., Schelling, E., & Zinsstag, J. (2012). Global burden of human brucellosis: A systematic review of disease frequency. PLoS Neglected Tropical Diseases, 6, e1865.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Dean, A. S., Crump, L., Greter, H., Hattendorf, J., Schelling, E., & Zinsstag, J. (2012). Clinical manifestations of human brucellosis: A systematic review and meta-analysis. PLoS Neglected Tropical Diseases, 6, e1929.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Karaman, K., Akbayram, S., Kaba, S., Karaman, S., Garipardiç, M., Aydin, I., et al. (2016). An analysis of children with brucellosis associated with haemophagocytic lymphohistiocytosis. Le Infezioni in Medicina, 24, 123–130.

    PubMed  Google Scholar 

  8. Yaman, Y., Gözmen, S., Özkaya, A. K., Oymak, Y., Apa, H., Vergin, C., et al. (2015). Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: Report of three cases. Journal of Infection in Developing Countries, 9, 1172–1176.

    Article  CAS  PubMed  Google Scholar 

  9. Erduran, E., Makuloglu, M., & Mutlu, M. (2010). A rare hematological manifestation of brucellosis: Reactive hemophagocytic syndrome. Journal of Microbiology, Immunology, and Infection, 43, 159–162.

    Article  PubMed  Google Scholar 

  10. Mondal, N., Suresh, R., Acharya, N. S., Praharaj, I., Harish, B. N., & Mahadevan, S. (2010). Hemophagocytic syndrome in a child with brucellosis. Indian Journal of Pediatrics, 77, 1434–1436.

    Article  PubMed  Google Scholar 

  11. David, A., Iaria, C., Giordano, S., Iaria, M., & Cascio, A. (2012). Secondary hemophagocytic lymphohistiocytosis: Forget me not! Transplant Infectious Disease, 14, E121–E123.

    Article  CAS  PubMed  Google Scholar 

  12. Dumler, J. S., Madigan, J. E., Pusterla, N., & Bakken, J. S. (2007). Ehrlichioses in humans: Epidemiology, clinical presentation, diagnosis, and treatment. Clinical Infectious Diseases, 45(Suppl 1), S45–S51.

    Article  PubMed  Google Scholar 

  13. Parola, P., Paddock, C. D., & Raoult, D. (2005). Tick-borne rickettsioses around the world: Emerging diseases challenging old concepts. Clinical Microbiology Reviews, 18, 719–756.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Jayakrishnan, M. P., Veny, J., & Feroze, M. (2011). Rickettsial infection with hemophagocytosis. Tropical Doctor, 41, 111–112.

    Article  CAS  PubMed  Google Scholar 

  15. Walter, G., Botelho-Nevers, E., Socolovschi, C., Raoult, D., & Parola, P. (2012). Murine typhus in returned travelers: A report of thirty-two cases. The American Journal of Tropical Medicine and Hygiene, 86, 1049–1053.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Cascio, A., Giordano, S., Dones, P., Venezia, S., Iaria, C., & Ziino, O. (2011). Haemophagocytic syndrome and rickettsial diseases. Journal of Medical Microbiology, 60, 537–542.

    Article  PubMed  Google Scholar 

  17. Premaratna, R., Williams, H. S., Chandrasena, T. G., Rajapakse, R. P., Kularatna, S. A., & de Silva, H. J. (2009). Unusual pancytopenia secondary to haemophagocytosis syndrome in rickettsioses. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103, 961–963.

    Article  CAS  PubMed  Google Scholar 

  18. Basheer, A., Padhi, S., Boopathy, V., Mallick, S., Nair, S., Varghese, R. G., et al. (2015 Jan 1). Hemophagocytic Lymphohistiocytosis: an Unusual Complication of Orientia tsutsugamushi Disease (Scrub Typhus). Mediterr J Hematol Infect Dis., 7(1), e2015008.

    PubMed  PubMed Central  Google Scholar 

  19. Kwon, H. J., Yoo, I. H., Lee, J. W., Chung, N. G., Cho, B., Kim, H. K., et al. (2013 Feb). Life-threatening scrub typhus with hemophagocytosis and acute respiratory distress syndrome in an infant. J Trop Pediatr., 59(1), 67–69.

    Article  PubMed  Google Scholar 

  20. Otsuki, S., Iwamoto, S., Azuma, E., Nashida, Y., Akachi, S., Taniguchi, K., et al. (2015). Hemophagocytic Lymphohistiocytosis due to rickettsia japonica in a 3-month-old infant. Journal of Pediatric Hematology/Oncology, 37, 627–628.

    Article  PubMed  Google Scholar 

  21. Dumler, J. S. (2005). Anaplasma and Ehrlichia infection. Annals of the New York Academy of Sciences, 1063, 361–373.

    Article  PubMed  Google Scholar 

  22. Paddock, C. D., & Childs, J. E. (2003). Ehrlichia chaffeensis: A prototypical emerging pathogen. Clinical Microbiology Reviews, 16, 37–64.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Dumler, J. S., Choi, K. S., Garcia-Garcia, J. C., Barat, N. S., Scorpio, D. G., Garyu, J. W., et al. (2005). Human granulocytic anaplasmosis and Anaplasma phagocytophilum. Emerging Infectious Diseases, 11, 1828–1834.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Lantos, P. M., & Krause, P. J. (2002). Ehrlichiosis in children. Seminars in Pediatric Infectious Diseases, 13, 249–256.

    Article  PubMed  Google Scholar 

  25. Pujalte, G. G., & Chua, J. V. (2013). Tick-borne infections in the United States. Primary Care, 40, 619–635.

    Article  PubMed  Google Scholar 

  26. Dahlgren, F. S., Heitman, K. N., & Behravesh, C. B. (2016). Undetermined human ehrlichiosis and anaplasmosis in the United States, 2008–2012: A catch-all for passive surveillance. The American Journal of Tropical Medicine and Hygiene, 94, 299–301.

    Article  PubMed  CAS  Google Scholar 

  27. Dahlgren, F. S., Mandel, E. J., Krebs, J. W., Massung, R. F., & McQuiston, J. H. (2011). Increasing incidence of Ehrlichia chaffeensis and Anaplasma phagocytophilum in the United States, 2000–2007. The American Journal of Tropical Medicine and Hygiene, 85, 124–131.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Ismail, N., Olano, J. P., Feng, H. M., & Walker, D. H. (2002). Current status of immune mechanisms of killing of intracellular microorganisms. FEMS Microbiology Letters, 207, 111–120.

    Article  CAS  PubMed  Google Scholar 

  29. Ismail, N., Soong, L., McBride, J. W., Valbuena, G., Olano, J. P., Feng, H. M., et al. (2004). Overproduction of TNF-alpha by CD8+ type 1 cells and down-regulation of IFN-gamma production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichiosis. Journal of Immunology, 172, 1786–1800.

    Article  CAS  Google Scholar 

  30. Ismail, N., Stevenson, H. L., & Walker, D. H. (2006). Role of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis: Increased resistance of TNF receptor p55- and p75-deficient mice to fatal ehrlichial infection. Infection and Immunity, 74, 1846–1856.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Otrock, Z. K., Eby, C. S., & Burnham, C. D. (2019). Human ehrlichiosis at a tertiary-care academic medical center: Clinical associations and outcomes of transplant patients and patients with hemophagocytic lymphohistiocytosis. Blood Cells Mol Dis., 77, 17–22.

    Article  PubMed  Google Scholar 

  32. Statler, V. A., & Marshall, G. S. (2015). Hemophagocytic lymphohistiocytosis induced by monocytic ehrlichiosis. The Journal of Pediatrics, 166, 499–99.e1.

    Article  PubMed  Google Scholar 

  33. Kumar, N., Goyal, J., Goel, A., Shakoory, B., & Chatham, W. (2014). Macrophage activation syndrome secondary to human monocytic ehrlichiosis. Indian Journal of Hematology and Blood Transfusion, 30(Suppl 1), 145–147.

    Article  PubMed  Google Scholar 

  34. Naqash, A. R., Yogarajah, M., Vallangeon, B. D., Hafiz, M., Patel, D., Kolychev, E., et al. (2017). Hemophagocytic lymphohistiocytosis (HLH) secondary to Ehrlichia chaffeensis with bone marrow involvement. Annals of Hematology, 96, 1755–1758.

    Article  PubMed  Google Scholar 

  35. Cheng, A., Williams, F., Fortenberry, J., Preissig, C., Salinas, S., & Kamat, P. (2016). Use of extracorporeal support in Hemophagocytic Lymphohistiocytosis secondary to Ehrlichiosis. Pediatrics, 138(4), e20154176.

    Article  PubMed  Google Scholar 

  36. Kaplan, R. M., Swat, S. A., & Singer, B. D. (2016). Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. Diagnostic Microbiology and Infectious Disease, 86, 327–328.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Vijayan, V., Thambundit, A., & Sukumaran, S. (2015). Hemophagocytic lymphohistiocytosis secondary to ehrlichiosis in a child. Clinical Pediatrics (Phila), 54, 84–86.

    Article  Google Scholar 

  38. Pandey, R., Kochar, R., Kemp, S., Rotaru, D., & Shah, S. V. (2013). Ehrlichiosis presenting with toxic shock-like syndrome and secondary hemophagocytic lymphohistiocytosis. The Journal of the Arkansas Medical Society, 109, 280–282.

    PubMed  Google Scholar 

  39. Hanson, D., Walter, A. W., & Powell, J. (2011). Ehrlichia-induced hemophagocytic lymphohistiocytosis in two children. Pediatric Blood & Cancer, 56, 661–663.

    Article  Google Scholar 

  40. Burns, S., Saylors, R., & Mian, A. (2010). Hemophagocytic lymphohistiocytosis secondary to Ehrlichia chaffeensis infection: A case report. Journal of Pediatric Hematology/Oncology, 32, e142–e143.

    Article  PubMed  Google Scholar 

  41. Otrock, Z. K., & Eby, C. S. (2015). Clinical characteristics, prognostic factors, and outcomes of adult patients with hemophagocytic lymphohistiocytosis. American Journal of Hematology, 90, 220–224.

    Article  CAS  PubMed  Google Scholar 

  42. Parikh, S. A., Kapoor, P., Letendre, L., Kumar, S., & Wolanskyj, A. P. (2014). Prognostic factors and outcomes of adults with hemophagocytic lymphohistiocytosis. Mayo Clinic Proceedings, 89, 484–492.

    Article  PubMed  Google Scholar 

  43. Shabbir, M., Lucas, J., Lazarchick, J., & Shirai, K. (2011). Secondary hemophagocytic syndrome in adults: A case series of 18 patients in a single institution and a review of literature. Hematological Oncology, 29, 100–106.

    Article  PubMed  Google Scholar 

  44. Anderson, A., Bijlmer, H., Fournier, P. E., Graves, S., Hartzell, J., Kersh, G. J., et al. (2013). Diagnosis and management of Q fever–United States, 2013: Recommendations from CDC and the Q fever working group. MMWR - Recommendations and Reports, 62, 1–30.

    PubMed  Google Scholar 

  45. Million, M., & Raoult, D. (2015). Recent advances in the study of Q fever epidemiology, diagnosis and management. The Journal of Infection, 71(Suppl 1), S2–S9.

    Article  PubMed  Google Scholar 

  46. Amara, A. B., Bechah, Y., & Mege, J. L. (2012). Immune response and Coxiella burnetii invasion. Advances in Experimental Medicine and Biology, 984, 287–298.

    Article  PubMed  CAS  Google Scholar 

  47. Chen, T. C., Chang, K., Lu, P. L., Liu, Y. C., Chen, Y. H., Hsieh, H. C., et al. (2006). Acute Q fever with hemophagocytic syndrome: Case report and literature review. Scandinavian Journal of Infectious Diseases, 38, 1119–1122.

    Article  PubMed  Google Scholar 

  48. Harris, P., Dixit, R., & Norton, R. (2011). Coxiella burnetii causing haemophagocytic syndrome: A rare complication of an unusual pathogen. Infection, 39, 579–582.

    Article  CAS  PubMed  Google Scholar 

  49. Paine, A., Miya, T., & Webb, B. J. (2015). Coxiella burnetii infection with severe hyperferritinemia in an asplenic patient. Open Forum Infectious Diseases, 2, ofv125.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Padhi, S., Ravichandran, K., Sahoo, J., Varghese, R. G., & Basheer, A. (2015). Hemophagocytic lymphohistiocytosis: An unusual complication in disseminated Mycobacterium tuberculosis. Lung India, 32, 593–601.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Grandjean Lapierre, S., Toro, A., & Drancourt, M. (2017). Mycobacterium iranicum bacteremia and hemophagocytic lymphohistiocytosis: A case report. BMC Research Notes, 10, 372.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Castelli, A. A., Rosenthal, D. G., Bender Ignacio, R., & Chu, H. Y. (2015). Hemophagocytic Lymphohistiocytosis secondary to human immunodeficiency virus-associated Histoplasmosis. Open Forum Infectious Diseases, 2, ofv140.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  53. Yang, W. K., Fu, L. S., Lan, J. L., Shen, G. H., Chou, G., Tseng, C. F., et al. (2003). Mycobacterium avium complex-associated hemophagocytic syndrome in systemic lupus erythematosus patient: Report of one case. Lupus, 12, 312–316.

    Article  CAS  PubMed  Google Scholar 

  54. Chamsi-Pasha, M. A., Alraies, M. C., Alraiyes, A. H., & Hsi, E. D. (2013). Mycobacterium avium complex-associated hemophagocytic lymphohistiocytosis in a sickle cell patient: An unusual fatal association. Case Reports in Hematology, 2013, 291518.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Henry Ford Hospital, Detroit, MI, USA

    Zaher K. Otrock & Charles S. Eby

  2. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

    Zaher K. Otrock & Charles S. Eby

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  1. Zaher K. Otrock
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  2. Charles S. Eby
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Correspondence to Zaher K. Otrock .

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Editors and Affiliations

  1. UAB School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    Randy Q. Cron

  2. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Edward M. Behrens

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Otrock, Z.K., Eby, C.S. (2019). Zoonotic Bacterial Infections Triggering Cytokine Storm Syndrome. In: Cron, R., Behrens, E. (eds) Cytokine Storm Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-030-22094-5_19

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