Skip to main content

Investigation of the Properties of the Heavy Scintillating Fibers for Their Potential Use in Hadron Therapy Monitoring

Part of the Springer Proceedings in Physics book series (SPPHY,volume 227)

Abstract

Recent development in the production of inorganic scintillators resulted in a variety of materials, many of which show excellent timing properties and large light yield. Due to large densities and effective atomic numbers, those materials are well suited for detection of a-few-MeV prompt gamma radiation, which is emitted during hadron therapy. Additionally, when combined with modern silicon photomultipliers (SiPM), they allow compact and granular detector designs. Therefore, heavy scintillators seem to be promising candidates for prompt gamma imaging (PGI) detectors, such as Compton cameras. Under the SiFi-CC (SiPM and Fiber based Compton Camera) project the investigation of heavy scintillating materials for their application in hadron therapy monitoring has been carried out. The study was focused on lutetium based crystals, including LuAG:Ce and LYSO:Ce as well as recently developed GAGG:Ce,Mg. Examined samples had an elongated, fiber-like shape, with 100 mm length and 1 × 1 mm2 square cross section. The following features of such fibers were investigated: attenuation length of the optical photons, light yield, energy resolution and timing characteristics. The study has shown that out of the materials chosen for the study LYSO:Ce is the most promising candidate for applications in PGI. Additionally, in order to optimize performance of scintillators an influence of wrapping was investigated. It has been observed that aluminum wrapping causes an increase in the light yield, but decreases the attenuation length.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-030-21970-3_14
  • Chapter length: 16 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   109.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-21970-3
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   149.99
Price excludes VAT (USA)
Hardcover Book
USD   199.99
Price excludes VAT (USA)
Fig. 14.1
Fig. 14.2
Fig. 14.3
Fig. 14.4
Fig. 14.5
Fig. 14.6
Fig. 14.7
Fig. 14.8
Fig. 14.9
Fig. 14.10
Fig. 14.11

References

  1. Nuclear Physics European Collaboration Committee, Nuclear Physics for Medicine (2014)

    Google Scholar 

  2. H. Paganetti et al., Range uncertainties in proton therapy and the role of Monte Carlo simulations. Phys. Med. Biol. 57, R99–R117 (2013)

    CrossRef  Google Scholar 

  3. K. Parodi, Vision 20/20: Positron emission tomography in radiation therapy planning, delivery, and monitoring. Med. Phys. 42, 7153–7168 (2015)

    CrossRef  Google Scholar 

  4. P.C. Lopes et al., First in situ TOF-PET study using digital photon counters for proton range verification. Phys Med Biol. 61, 6203–6230 (2016)

    Google Scholar 

  5. V. Ferrero et al., Online proton therapy monitoring: clinical test of a silicon-photodetector-based in-beam PET. Sci Rep. 8, 4100 (2018)

    ADS  CrossRef  Google Scholar 

  6. M. Pinto et al., Absolute prompt-gamma yield measurements for ion beam therapy monitoring. Phys. Med. Biol. 60, 565–594 (2015)

    CrossRef  Google Scholar 

  7. L. Kelleter et al., Spectroscopic study of prompt-gamma emission for range verification in proton therapy. Phys Med. 34, 7–17 (2017)

    CrossRef  Google Scholar 

  8. C.H. Min et al., Prompt gamma measurements for locating the dose falloff region in the proton therapy. Appl. Phys. Lett. 89, 183517 (2006)

    ADS  CrossRef  Google Scholar 

  9. J.M. Verburg et at., Proton range verification through prompt gamma-ray spectroscopy. Phys Med Biol. 59, 7089–7106 (2014)

    ADS  CrossRef  Google Scholar 

  10. J. Smeets et al., Prompt gamma imaging with a slit camera for real-time range control in proton therapy. Phys. Med. Biol. 57, 3371–3405 (2012)

    CrossRef  Google Scholar 

  11. V. Bom, L. Joulaeizadeh, F. Beekman, Real-time prompt gamma monitoring in spot-scanning proton therapy using imaging through a knife-edge-shaped slit. Phys. Med. Biol. 57, 297–308 (2012)

    CrossRef  Google Scholar 

  12. C. Richter et al., First clinical application of a prompt gamma based in vivo proton range verification system. Radiother. Oncol. 118, 232–237 (2016)

    CrossRef  Google Scholar 

  13. C.H. Min et al., Development of array-type prompt gamma measurement system for in vivo range verification in proton therapy. Med. Phys. 39, 2100–2107 (2012)

    CrossRef  Google Scholar 

  14. M. Pinto et al., Design optimisation of a TOF-based collimated camera prototype for online hadrontherapy monitoring. Phys. Med. Biol. 59, 7653–7674 (2014)

    ADS  CrossRef  Google Scholar 

  15. J. Krimmer et al., Collimated prompt gamma TOF measurements with multi-slit multi-detector configurations. J. Instrum. 10, P01011–P01011 (2015)

    CrossRef  Google Scholar 

  16. F. Hueso-González et al., A full-scale clinical prototype for proton range verification using prompt gamma-ray spectroscopy. Phys. Med. Biol. 63, 185019 (2018)

    CrossRef  Google Scholar 

  17. F. Hueso-González et al., First test of the prompt gamma ray timing method with heterogeneous targets at a clinical proton therapy facility. Phys. Med. Biol. 60, 6247–6272 (2015)

    CrossRef  Google Scholar 

  18. C. Golnik et al., Range assessment in particle therapy based on prompt γ-ray timing measurements. Phys. Med. Biol. 59, 5399–5422 (2014)

    CrossRef  Google Scholar 

  19. J. Petzoldt et al., Characterization of the microbunch time structure of proton pencil beams at a clinical treatment facility. Phys. Med. Biol. 61, 2432–2456 (2016)

    CrossRef  Google Scholar 

  20. T. Kormoll et al., A Compton imager for in-vivo dosimetry of proton beams—a design study. Nucl. Instrum. Methods Phys. A 626–627, 114–119 (2011)

    ADS  CrossRef  Google Scholar 

  21. M.H. Richard et al., Design study of the absorber detector of a Compton camera for on-line control in ion beam therapy. IEEE Trans. Nucl. Sci. 59, 1850–1855 (2012)

    ADS  CrossRef  Google Scholar 

  22. S. Aldawood et al., Development of a Compton camera for prompt-gamma medical imaging. Radiat. Phys. Chem. 140, 190–197 (2017)

    ADS  CrossRef  Google Scholar 

  23. J.C. Polf et al., Imaging of prompt gamma rays emitted during delivery of clinical proton beams with a Compton camera: feasibility studies for range verification. Phys. Med. Biol. 60, 7085–7099 (2015)

    CrossRef  Google Scholar 

  24. G. Llosá et al., First images of a three-layer Compton Telescope prototype for treatment monitoring in Hadron Therapy. Front. Oncol. 6, 14 (2016)

    CrossRef  Google Scholar 

  25. F. Hueso-Gonzalez et al., in Prompt gamma imaging of a pencil beam with a high efficiency Compton camera at a clinical proton therapy facility. 2015 IEEE Nuclear Science Symposium and Medical imaging Conference (NSS/MIC 2015) (2016), pp. 6–9

    Google Scholar 

  26. H. Rohling et al., Requirements for a Compton camera for in vivo range verification of proton therapy. Phys. Med. Biol. 62, 2795–2811 (2017)

    CrossRef  Google Scholar 

  27. E. Draeger et al., 3D prompt gamma imaging for proton beam range verification. Phys. Med. Biol. 63, 035019 (2018)

    CrossRef  Google Scholar 

  28. K. Lebbou, Single crystals fiber technology design. Where we are today? Opt Mat. 63, 13–18 (2017)

    ADS  CrossRef  Google Scholar 

  29. M.T. Lucchini et al., Test beam results with LuAG fibers for next-generation calorimeters. J. Inst. 8, P10017–P10017 (2013)

    Google Scholar 

  30. A. Benaglia et al., Test beam results of a high granularity LuAG fibre calorimeter prototype. J. Inst. 11, P05004–P05004 (2016)

    Google Scholar 

  31. J. Kataoka et al., Recent progress of MPPC-based scintillation detectors in high precision X-ray and gamma-ray imaging. Nucl. Instrum. Methods Phys. A 784, 248–254 (2015)

    ADS  CrossRef  Google Scholar 

  32. A. Kishimoto et al., Development of a compact scintillator-based high-resolution Compton camera for molecular imaging. Nucl. Instrum. Methods Phys. A 845, 656–659 (2017)

    ADS  CrossRef  Google Scholar 

  33. P. Lecoq, Development of new scintillators for medical applications. Nucl. Instrum. Methods Phys. A 809, 130–139 (2016)

    ADS  CrossRef  Google Scholar 

  34. K. Kamada et al., Large size Czochralski growth and scintillation properties of Mg2+ co-doped Ce: Gd3Ga3Al2O12. IEEE Trans. Nucl. Sci. 63, 443–447 (2016)

    ADS  CrossRef  Google Scholar 

  35. K. Kamada et al., Alkali earth co-doping effects on luminescence and scintillation properties of Ce doped Gd3Al2Ga3O12 scintillator. Opt. Mater. 41, 63–66 (2015)

    ADS  CrossRef  Google Scholar 

  36. M.T. Lucchini et al., Effect of Mg2+ ions co-doping on timing performance and radiation tolerance of cerium doped Gd3Al2Ga3O12 crystals. Nucl. Instrum. Methods Phys. A 816, 176–183 (2016)

    ADS  CrossRef  Google Scholar 

  37. S. Gaundacker et al., Measurement of intrinsic rise times for various L(Y)SO and LuAG scintillators with a general study of prompt photons to achieve 10 ps in TOF-PET. Phys. Med. Biol. 61, 2802 (2016)

    CrossRef  Google Scholar 

  38. K. Pauwels et al., Single crystalline LuAG fibers for homogeneous dual-readout calorimeters. J. Instrum. 8, P09019–P09019 (2013)

    CrossRef  Google Scholar 

  39. I. Vilardi et al., Optimization of the effective light attenuation length of YAP:Ce and LYSO:Ce crystals for a novel geometrical PET concept. Nucl. Instrum. Methods Phys. A 564, 506–514 (2006)

    ADS  CrossRef  Google Scholar 

  40. P. Anfré et al., Evaluation of fiber-shaped LYSO for double readout gamma photon detection. IEEE Trans. Nucl. Sci. 54, 391–397 (2007)

    ADS  CrossRef  Google Scholar 

  41. Y. Shao et al., Dual APD array readout of LSO crystals: optimization of crystal surface treatment. IEEE Trans. Nucl. Sci. 49, 649–654 (2002)

    ADS  CrossRef  Google Scholar 

  42. J. Iwanowska et al., Performance of cerium-doped Gd3Al2Ga3O12 (GAGG:Ce) scintillator in gamma-ray spectroscopy. Nucl. Instrum. Methods Phys. A 712, 34–40 (2013)

    ADS  CrossRef  Google Scholar 

Download references

Acknowledgements

The authors wish to express their gratitude to T. Kołodziej and Z. Baster (Department of Molecular and Interfacial Biophysics, Jagiellonian University), K. Kamada, A. Yoshikawa and Y. Ugaji (C&A Corporation).

The research has been founded under the Sonata Bis grant by Polish National Science Center (2017/26/E/ST2/00618) and the DSC 2017 and DSC 2018 grants for young researchers at the Faculty of Physics, Astronomy and Applied Computer Science of the Jagiellonian University (7150/E-338/M/2017 and 7150/E-338/M/2018).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K. Rusiecka .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this paper

Verify currency and authenticity via CrossMark

Cite this paper

Rusiecka, K., Kasper, J., Magiera, A., Stahl, A., Wrońska, A. (2019). Investigation of the Properties of the Heavy Scintillating Fibers for Their Potential Use in Hadron Therapy Monitoring. In: Korzhik, M., Gektin, A. (eds) Engineering of Scintillation Materials and Radiation Technologies. ISMART 2018. Springer Proceedings in Physics, vol 227. Springer, Cham. https://doi.org/10.1007/978-3-030-21970-3_14

Download citation