Automatic Image-Derived Estimation of the Arterial Whole-Blood Input Function from Dynamic Cerebral PET with \(^{18}\)F-Choline

  • Carlos González
  • Pedro BibiloniEmail author
  • Manuel González-Hidalgo
  • Arnau Mir
  • Sebastià Rubí
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11526)


The arterial concentration of the radiopharmaceutical \({}^{18}\text {F}\)-choline is needed to estimate its absorption by tumors and other tissues. The blood concentration of \({}^{18}\text {F}\)-choline changes as it interacts with tissues, and so it is represented as a function with respect to time, the so-called Input Function (IF). In this paper, we present the estimation of an arterial whole-blood Image-Derived Input Function (IDIF) from the PET image, needed to model its absorption. The sagittal and transverse brain venous sinuses are automatically segmented based on the top-hat morphological transform. Such segmentation provides an estimation of the venous whole-blood IDIF. It is then corrected to obtain the arterial whole-blood IDIF by relating the amount of radioactivity material entering the brain region with the amount leaving it and the amount remaining. We compare the automatic venous whole-blood IDIF with a whole-blood venous IDIF from a region manually segmented. Also, we compare the automatic arterial whole-blood IDIF with the arterial IF obtained with serial blood samples on the radial artery. Quantitative measures indicate the overall accuracy of the estimation.


PET \(^{18}\)F-choline Image processing Vessel segmentation Input function Image-derived input function Top-hat morphological transform 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Carlos González
    • 1
  • Pedro Bibiloni
    • 1
    • 2
    Email author
  • Manuel González-Hidalgo
    • 1
    • 2
  • Arnau Mir
    • 1
    • 2
  • Sebastià Rubí
    • 2
    • 3
  1. 1.SCOPIA Research GroupUniversitat de les Illes BalearsPalmaSpain
  2. 2.Balearic Islands Health Research Institute (IdISBa)PalmaSpain
  3. 3.Department of Nuclear MedicineUniversity Hospital Son EspasesPalmaSpain

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