Modeling: The New Prospects of Studying Biological Systems as Illustrated by the Human Stomach

Conference paper
Part of the Lecture Notes in Earth System Sciences book series (LNESS)


Thermodynamic modeling was undertaken of the interactions between gastric juice and the mineral water sampled from the Marcial water well and spring in the vicinity of the city of Apatity. The study results make it possible to determine the migration forms of elements in the natural water—gastric juice system in a low and high acidity environment and the deposition conditions of the mineral phases that can be transported from the stomach to other organs and tissues. The physicochemical parameters (Eh and pH) of the studied gastric juice model were examined under normal conditions as well as deficient and excessive HCl. Important factors affecting the change in the gastric juice parameters are temperature and the intake of different mineral water varieties containing different concentrations of the individual elements. It was shown that, in stomach disorders, the transition of iron from the solution to the solid phase occurs, which may explain the anemic condition. A successful treatment of this condition requires restoring the acid-base parameters of the system. The study results complement the existing knowledge and open up new prospects of applying thermodynamic modeling methods to biological systems. An attempt was made to apply the thermodynamic modeling method to study the processes occurring in the human stomach.


Stomach model Metabolism Thermodynamic modeling Mineral metabolism Hyperacidity Hypoacidity Migration forms Newly formed phases 



The study was carried out with the financial support of RFBR and the Ministry of Education and Science of Murmansk Region as part of the research project 17-45-510640 p_a “Geochemical examination of the groundwater in the Khibiny Mountains (dating, identification of the origin, chemical composition, migration forms of the elements)”.


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Internet Reference

  1. Ministry of Natural Resources and Ecology of the Murmansk region (in Russian)

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Institute of North Industrial Ecology Problems—Subdivision of the Federal Research Centre “Kola Science Centre of the Russian Academy of Sciences”Akademgorodok, ApatityRussia
  2. 2.Russia Federal State Budgetary Institution of Science A.P. Vinogradov Institute of Geochemistry SB RASIrkutskRussia
  3. 3.Research Centre for Human Adaptation, Arctic—Branch of the Federal Research Centre, “Kola Science Centre of the Russian Academy of Science”Akademgorodok, ApatityRussia
  4. 4.Tananaev Institute of Chemistry—Subdivision of the Federal Research Centre, “Kola Science Centre of the Russian Academy of Sciences”Akademgorodok, ApatityRussia
  5. 5.Luzin Institute for Economic Studies—Subdivision of the Federal Research Centre, “Kola Science Centre of the Russian Academy of Sciences”ApatityRussia

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