Abstract
In the search for biomaterials that exhibit both versatility and compatibility with human-tissues, considerable interest has been shown in collagen-based biomaterial for the repair and replacement of the body tissues such as tendons, skin, vascular grafts, heart valves, dental and bones. Some of the general properties of collagen which makes it an interesting biomaterial are the high mechanical strength of the fibers, low antigenicity, its suitability as a substrate for cell growth, and its tunable stability by chemical or physical cross-linking. Collagen based composites are used in various biomedical applications as collagen shields in ophthalmology, sponges for burns and wounds, mini-pellets and tablets for protein delivery, gel formulation in combination with liposome for sustained drug delivery, as controlling material for transdermal delivery, basic matrices for cell culture systems, coating material of metal implant for bone replacement and 3-D printed matrix for various tissue engineering applications. For an adequate biomedical application of collagen, basic knowledge about collagen structure, hierarchical structural organisation and the processing technology in combination with understanding of the physico-chemical properties is of vital importance.
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References
Al‐Munajjed AA, Plunkett NA, Gleeson JP, Weber T, Jungreuthmayer C, Levingstone T, Hammer J, O’Brien FJ (2009) Development of a biomimetic collagen-hydroxyapatite scaffold for bone tissue engineering using a SBF immersion technique. J Biomed Mater Res B Appl Biomater 90B(2):584–591. https://doi.org/10.1002/jbm.b.31320
Ardelean IL, Gudovan D, Ficai D, Ficai A, Andronescu E, Albu-Kaya MG, Neacsu P, Ion RN, Cimpean A, Mitran V (2018) Collagen/hydroxyapatite bone grafts manufactured by homogeneous/heterogeneous 3D printing. Mater Lett 231:179–182. https://doi.org/10.1016/j.matlet.2018.08.042
Badylak Stephen F (2004) Xenogeneic extracellular matrix as a scaffold for tissue reconstruction. Transpl Immunol 12(3):367–377. https://doi.org/10.1016/j.trim.2003.12.016
Baheiraei N, Nourani MR, Mortazavi SM, Movahedin M, Eyni H, Bagheri F, Norahan MH (2018) Development of a bioactive porous collagen/β-tricalcium phosphate bone graft assisting rapid vascularization for bone tissue engineering applications. J Biomed Mater Res, Part A 106(1):73–85. https://doi.org/10.1002/jbm.a.36207
Charulatha V, Rajaram A (2003) Influence of different crosslinking treatments on the physical properties of collagen membranes. Biomaterials 24(5):759–767. https://doi.org/10.1016/S0142-9612(02)00412-X
Chen K-Y, Chung C-M, Kuo S-M, Chen Y-S, Yao C-H (2009) Influence of collagen I nanospheres on the growth and osteogenic difference of rat bone marrow stromal cells. J Med Biol Eng 29(6):284–289
Dai W, Kawazoe N, Lin X, Dong J, Chen G (2010) The influence of structural design of PLGA/collagen hybrid scaffolds in cartilage tissue engineering. Biomaterials 31(8):2141–2152. https://doi.org/10.1016/j.biomaterials.2009.11.070
Davidenko N, Campbell JJ, Thian ES, Watson CJ, Cameron RE (2010) Collagen–hyaluronic acid scaffolds for adipose tissue engineering. Acta Biomater 6(10):3957–3968. https://doi.org/10.1016/j.actbio.2010.05.005
Dawson JI, Oreffo ROC (2013) Clay: new opportunities for tissue regeneration and biomaterial design. Adv Mater 25(30):4069–4086. https://doi.org/10.1002/adma.201301034
Dorozhkin SV (2012) Biphasic, triphasic and multiphasic calcium orthophosphates. Acta Biomater 8(3):963–977. https://doi.org/10.1016/j.actbio.2011.09.003
Dunn MG, Bellincampi LD, Jr Tria, Alfred J, Zawadsky JP (1997) Preliminary development of a collagen-PLA composite for ACL reconstruction. J Appl Polym Sci 63(11):1423–1428. https://doi.org/10.1002/(SICI)1097-4628(19970314)63:11%3c1423:AID-APP4%3e3.0.CO;2-O
Fan D, Takawale A, Lee J, Kassiri Z (2012) Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease. Fibrogenesis & Tissue Repair 5(1):15. https://doi.org/10.1186/1755-1536-5-15
Faraji D, Jahandideh A, Asghari A, Akbarzadeh A, Hesaraki S (2017) Effect of zeolite and zeolite/collagen nanocomposite scaffolds on healing of segmental femur bone defect in rabbits. Iran J Vet Surg 12(2):63–70. https://doi.org/10.22034/ivsa.2018.112807.1133
Friess W (1998) Collagen—biomaterial for drug delivery. Eur J Pharm Biopharm 45(2):113–136. https://doi.org/10.1016/S0939-6411(98)00017-4
Gelse K, Pöschl E, Aigner T (2003) Collagens—structure, function, and biosynthesis. Adv Drug Deliv Rev 55(12):1531–1546. https://doi.org/10.1016/j.addr.2003.08.002
Guillaume O, Naqvi SM, Lennon K, Buckley CT (2015) Enhancing cell migration in shape-memory alginate–collagen composite scaffolds: in vitro and ex vivo assessment for intervertebral disc repair. J Biomater Appl 29(9):1230–1246. https://doi.org/10.1177/0885328214557905
Hiraoka Y, Kimura Y, Ueda H, Tabata Y (2003) Fabrication and biocompatibility of collagen sponge reinforced with poly(glycolic acid) fiber. Tissue Eng 9(6):1101–1112. https://doi.org/10.1089/10763270360728017
Hum J, Boccaccini AR (2018) Collagen as coating material for 45S5 bioactive glass-based scaffolds for bone tissue engineering. Int J Mol Sci 19(6):1807
Jones JR, Brauer DS, Hupa L, Greenspan DC (2016) Bioglass and bioactive glasses and their impact on healthcare. Int J Appl Glass Sci 7(4):423–434. https://doi.org/10.1111/ijag.12252
Jorge-Herrero E, Fernandez P, Turnay J, Olmo N, Calero P, Garcı́a R, Freile I, Castillo-Olivares JL (1999) Influence of different chemical cross-linking treatments on the properties of bovine pericardium and collagen. Biomaterials 20(6):539–545. https://doi.org/10.1016/S0142-9612(98)90205-8
Kane RJ, Weiss-Bilka HE, Meagher MJ, Liu Y, Gargac JA, Niebur GL, Wagner DR, Roeder RK (2015) Hydroxyapatite reinforced collagen scaffolds with improved architecture and mechanical properties. Acta Biomater 17:16–25. https://doi.org/10.1016/j.actbio.2015.01.031
Kim B-S, Kim JS, Lee J (2013) Improvements of osteoblast adhesion, proliferation, and differentiation in vitro via fibrin network formation in collagen sponge scaffold. J Biomed Mater Res, Part A 101A(9):2661–2666. https://doi.org/10.1002/jbm.a.34567
Kozłowska J, Sionkowska A (2015) Effects of different crosslinking methods on the properties of collagen–calcium phosphate composite materials. Int J Biol Macromol 74:397–403. https://doi.org/10.1016/j.ijbiomac.2014.12.023
Lee CH, Singla A, Lee Y (2001) Biomedical applications of collagen. Int J Pharm 221(1):1–22. https://doi.org/10.1016/S0378-5173(01)00691-3
Li H, He J, Yu H, Green CR, Chang J (2016) Bioglass promotes wound healing by affecting gap junction connexin 43 mediated endothelial cell behavior. Biomaterials 84:64–75. https://doi.org/10.1016/j.biomaterials.2016.01.033
Li W, Lan Y, Guo R, Zhang Y, Xue W, Zhang Y (2015) In vitro and in vivo evaluation of a novel collagen/cellulose nanocrystals scaffold for achieving the sustained release of basic fibroblast growth factor. J Biomater Appl 29(6):882–893. https://doi.org/10.1177/0885328214547091
Li Y, Thula TT, Jee S, Perkins SL, Aparicio C, Douglas EP, Gower LB (2012) Biomimetic mineralization of woven bone-like nanocomposites: role of collagen cross-links. Biomacromol 13(1):49–59. https://doi.org/10.1021/bm201070g
Liu Y, Ren L, Yao H, Wang Y (2012) Collagen films with suitable physical properties and biocompatibility for corneal tissue engineering prepared by ion leaching technique. Mater Lett 87:1–4. https://doi.org/10.1016/j.matlet.2012.07.091
Long T, Yang J, Shi S-S, Guo Y-P, Ke Q-F, Zhu Z-A (2015) Fabrication of three-dimensional porous scaffold based on collagen fiber and bioglass for bone tissue engineering. J Biomed Mater Res B Appl Biomater 103(7):1455–1464. https://doi.org/10.1002/jbm.b.33328
Lotz C, Schmid FF, Oechsle E, Monaghan MG, Walles H, Groeber-Becker F (2017) Cross-linked collagen hydrogel matrix resisting contraction to facilitate full-thickness skin equivalents. ACS Appl Mater Interfaces 9(24):20417–20425. https://doi.org/10.1021/acsami.7b04017
Marelli B, Ghezzi CE, Mohn D, Stark WJ, Barralet JE, Boccaccini AR, Nazhat SN (2011) Accelerated mineralization of dense collagen-nano bioactive glass hybrid gels increases scaffold stiffness and regulates osteoblastic function. Biomaterials 32(34):8915–8926. https://doi.org/10.1016/j.biomaterials.2011.08.016
Meena C, Mengi SA, Deshpande SG (1999) Biomedical and industrial applications of collagen. Proc Indian Acad Sci—Chem Sci 111(2):319–329. https://doi.org/10.1007/BF02871912
Mighri N, Mao J, Mighri F, Ajji A, Rouabhia M (2015) Chitosan-coated collagen membranes promote chondrocyte adhesion, growth, and interleukin-6 secretion. Materials 8(11):5413
Minardi S, Taraballi F, Wang X, Cabrera FJ, Van Eps JL, Robbins AB, Sandri M, Moreno MR, Weiner BK, Tasciotti E (2017) Biomimetic collagen/elastin meshes for ventral hernia repair in a rat model. Acta Biomater 50:165–177. https://doi.org/10.1016/j.actbio.2016.11.032
Miri AK, Muja N, Kamranpour NO, Lepry WC, Boccaccini AR, Clarke SA, Nazhat SN (2016) Ectopic bone formation in rapidly fabricated acellular injectable dense collagen-bioglass hybrid scaffolds via gel aspiration-ejection. Biomaterials 85:128–141. https://doi.org/10.1016/j.biomaterials.2016.01.047
Nimni ME, Harkness RD (1988) Molecular structures and functions of collagen. In: Nimni ME (ed) Collagen–biochemistry (pp 1–79). CRC Press, Boca Raton. https://doi.org/10.1201/9781351070799
Ogata K, Imazato S, Ehara A, Ebisu S, Kinomoto Y, Nakano T, Umakoshi Y (2005) Comparison of osteoblast responses to hydroxyapatite and hydroxyapatite/soluble calcium phosphate composites. J Biomed Mater Res, Part A 72A(2):127–135. https://doi.org/10.1002/jbm.a.30146
Ohno T, Tanisaka K, Hiraoka Y, Ushida T, Tamaki T, Tateishi T (2004) Effect of type I and type II collagen sponges as 3D scaffolds for hyaline cartilage-like tissue regeneration on phenotypic control of seeded chondrocytes in vitro. Mater Sci Eng, C 24(3):407–411. https://doi.org/10.1016/j.msec.2003.11.011
Oktay B, Kayaman-Apohan N, Erdem-Kuruca S, Süleymanoğlu M (2015) Fabrication of collagen immobilized electrospun poly(vinyl alcohol) scaffolds. Polym Adv Technol 26(8):978–987. https://doi.org/10.1002/pat.3512
Orban JM, Wilson LB, Kofroth JA, El-Kurdi MS, Maul TM, Vorp DA (2004) Crosslinking of collagen gels by transglutaminase. J Biomed Mater Res, Part A 68A(4):756–762. https://doi.org/10.1002/jbm.a.20110
Pannone PJ (2007) Trends in biomaterials research. Nova Publishers
Parenteau-Bareil R, Gauvin R, Berthod F (2010) Collagen-based biomaterials for tissue engineering applications. Materials 3(3):1863–1887. https://doi.org/10.3390/ma3031863
Powell HM, Boyce ST (2006) EDC cross-linking improves skin substitute strength and stability. Biomaterials 27(34):5821–5827. https://doi.org/10.1016/j.biomaterials.2006.07.030
Ramachandran GN, Kartha G (1954) Structure of collagen. Nature 174(4423):269–270. https://doi.org/10.1038/174269c0
Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (2004) Biomaterials science: an introduction to materials in medicine. Elsevier
Reyna-Valencia A, Chevallier P, Mantovani D (2012) Development of a collagen/clay nanocomposite biomaterial. Mater Sci Forum 706–709:461–466
Ryan EJ, Ryan AJ, González-Vázquez A, Philippart A, Ciraldo FE, Hobbs C, Nicolosi V, Boccaccini AR, Kearney CJ, O’Brien FJ (2019) Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo. Biomaterials 197:405–416. https://doi.org/10.1016/j.biomaterials.2019.01.031
Sakiyama-Elbert SE, Hubbell JA (2001) Functional biomaterials: design of novel biomaterials. Annu Rev Mater Res 31(1):183–201. https://doi.org/10.1146/annurev.matsci.31.1.183
Samavedi S, Whittington AR, Goldstein AS (2013) Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior. Acta Biomater 9(9):8037–8045. https://doi.org/10.1016/j.actbio.2013.06.014
Sargeant TD, Desai AP, Banerjee S, Agawu A, Stopek JB (2012) An in situ forming collagen–PEG hydrogel for tissue regeneration. Acta Biomater 8(1):124–132. https://doi.org/10.1016/j.actbio.2011.07.028
Sharifi E, Ebrahimi‐Barough S, Panahi M, Azami M, Ai A, Barabadi Z, Kajbafzadeh AM, Ai J (2016) In vitro evaluation of human endometrial stem cell-derived osteoblast-like cells’ behavior on gelatin/collagen/bioglass nanofibers’ scaffolds. J Biomed Mater Res, Part A 104(9):2210–2219. https://doi.org/10.1002/jbm.a.35748
Sinha VR, Trehan Aman (2003) Biodegradable microspheres for protein delivery. J Controlled Release 90(3):261–280. https://doi.org/10.1016/S0168-3659(03)00194-9
Sionkowska A, Kozłowska J (2013) Properties and modification of porous 3-D collagen/hydroxyapatite composites. Int J Biol Macromol 52:250–259. https://doi.org/10.1016/j.ijbiomac.2012.10.002
Socrates R, Prymak O, Loza K, Sakthivel N, Rajaram A, Epple M, Narayana Kalkura S (2019) Biomimetic fabrication of mineralized composite films of nanosilver loaded native fibrillar collagen and chitosan. Mater Sci Eng, C 99:357–366. https://doi.org/10.1016/j.msec.2019.01.101
Socrates R, Sakthivel N, Rajaram A, Ramamoorthy Usha, Narayana Kalkura S (2015) Novel fibrillar collagen–hydroxyapatite matrices loaded with silver nanoparticles for orthopedic application. Mater Lett 161:759–762. https://doi.org/10.1016/j.matlet.2015.09.089
Sousa I, Mendes A, Bártolo PJ (2013) PCL scaffolds with collagen bioactivator for applications in tissue engineering. Procedia Eng 59:279–284. https://doi.org/10.1016/j.proeng.2013.05.122
Stamov DR, Pompe T (2012) Structure and function of ECM-inspired composite collagen type I scaffolds. Soft Matter 8(40):10200–10212. https://doi.org/10.1039/C2SM26134K
Sundararaghavan HG, Monteiro GA, Lapin NA, Chabal YJ, Miksan JR, Shreiber DI (2008) Genipin-induced changes in collagen gels: correlation of mechanical properties to fluorescence. J Biomed Mater Res, Part A 87A(2):308–320. https://doi.org/10.1002/jbm.a.31715
Usha R, Sreeram KJ, Rajaram A (2012) Stabilization of collagen with EDC/NHS in the presence of l-lysine: a comprehensive study. Colloids Surf, B 90:83–90. https://doi.org/10.1016/j.colsurfb.2011.10.002
Vallet-Regí M, González-Calbet JM (2004) Calcium phosphates as substitution of bone tissues. Prog Solid State Chem 32(1):1–31. https://doi.org/10.1016/j.progsolidstchem.2004.07.001
Villa MM, Wang L, Huang J, Rowe DW, Wei M (2015) Bone tissue engineering with a collagen–hydroxyapatite scaffold and culture expanded bone marrow stromal cells. J Biomed Mater Res B Appl Biomater 103(2):243–253. https://doi.org/10.1002/jbm.b.33225
Xia Z, Villa MM, Wei M (2014) A biomimetic collagen–apatite scaffold with a multi-level lamellar structure for bone tissue engineering. J Mater Chem B 2(14):1998–2007. https://doi.org/10.1039/C3TB21595D
Xu Y, Zhang Z, Chen X, Li R, Li D, Feng S (2016) A silk fibroin/collagen nerve scaffold seeded with a co-culture of Schwann cells and adipose-derived stem cells for sciatic nerve regeneration. PLoS ONE 11(1):e0147184. https://doi.org/10.1371/journal.pone.0147184
Yamamoto M, Yanase K, Tabata Y (2010) Generation of type I collagen gradient in polyacrylamide hydrogels by a simple diffusion-controlled hydrolysis of amide groups. Materials 3(4). https://doi.org/10.3390/ma3042393
Yamauchi K, Goda T, Takeuchi N, Einaga H, Tanabe T (2004) Preparation of collagen/calcium phosphate multilayer sheet using enzymatic mineralization. Biomaterials 25(24):5481–5489. https://doi.org/10.1016/j.biomaterials.2003.12.057
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We would like to thank and acknowledge the financial support from Indo-French Centre for the Promotion of Advanced Research, IFCPAR/CEFIPRA (Project No. 5608-1).
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Radhakrishnan, S., Nagarajan, S., Bechelany, M., Kalkura, S.N. (2020). Collagen Based Biomaterials for Tissue Engineering Applications: A Review. In: Frank-Kamenetskaya, O., Vlasov, D., Panova, E., Lessovaia, S. (eds) Processes and Phenomena on the Boundary Between Biogenic and Abiogenic Nature. Lecture Notes in Earth System Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-21614-6_1
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