Abstract
This chapter is a brief but comprehensive overview of topics that will be tested in the Pediatric Boards. It covers a wide range of conditions, including benign hematology, malignant hematology, bone tumors, brain tumors, and abdominal masses. It discusses the differential diagnoses, pathophysiology, workup, classic laboratory features, and treatment options for a range of pediatric hematologic and oncologic conditions. This is a high yield review for the pediatric boards.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kliegman R, Stanton B, St. Geme JW III, Schor NF, Behrman RE, editors. Nelson textbook of pediatrics. Philadelphia: Elsevier; 2016.
Loghavi S, Hasserjian RP. Cytopenias: reactive and neoplastic. In: Wang SA, Hasserjian RP, editors. Diagnosis of blood and bone marrow disorders. Cham: Springer International. p. 17–80.
Rogers HJ. Normal bone marrow. In: George TI, Arber DA, editors. Atlas of bone marrow pathology. New York: Science+Business Media; 2018.
Schafernak KT, Calvo KR. Constitutional, metabolic, and related disorders. In: George TI, Arber DA, editors. Atlas of bone marrow pathology. New York: Science+Business Media; 2018. p. 33–66.
Penanchansky L. Pediatric bone marrow. Berlin: Springer; 2004.
Suggested Reading
Adams M, Jenney M, Lazarou L, White R, Birdsall S, Staab T, et al. Acute myeloid leukaemia after treatment for acute lymphoblastic leukaemia in girl with Bloomsyndrome. J Genet Syndr Gene Ther. 2013;4(8). pii: 1000177.
Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998;339(1):5–11.
Adams RJ, Brambilla D, Optimizing Primary Stroke Prevention in Sickle Cell Anemia (STOP 2) Trial Investigators. Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease. N Engl J Med. 2005;353(26):2769–78.
Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998;339(1):5–11.
Bain B. Diagnosis from the blood smear. N Engl J Med. 2005;353(5):498–507.
Bolton-Maggs PH, Langer JC, Iolascon A, Tittensor P, King MJ, General Haematology Task Force of the British Committee for Standards in Haematology. Guidelines for the diagnosis and management of hereditary spherocytosis – 2011 update. Br J Haematol. 2012;156(1):37–49.
Buitenkamp TD, Izraeli S, Zimmermann M, Forestier E, Heerema NA, van den Heuvel-Eibrink MM, et al. Acute lymphoblastic leukemia in children with Down Syndrome: a retrospective analysis from the Ponte Di Legno study group. Blood. 2014;123(1):70–7.
Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;372(19):1832–43.
DeLoughery T. Microcytic anemia. New Engl J Med. 2014;371(14):1324–31.
Haupt R, Minkov M, Astigarraga I, Schäfer E, Nanduri V, Jubran R, Euro Histio Network, et al. Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Pediatr Blood Cancer. 2013;60(2):175–84.
Horton TM, Steuber CP, Aster JC. Park JR, editor. Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children. Waltham: UpToDate. http://www.uptodate.com. Accessed 24 Dec 2018.
Karimi M. Guidelines for diagnosis and management of Beta-thalassemia intermedia. Pediatr Hematol Oncol. 2014–10;31:583–96.
Kliegman R, Stanton B, St. Geme JW III, Schor NF, Behrman RE, editors. Nelson textbook of pediatrics. Philadelphia: Elsevier; 2016.
Levin TL, Mäkitie O, Berdon WE, Lachman RS. Shwachman–Bodian–Diamond Syndrome: metaphyseal chondrodysplasia in children with pancreatic insufficiency and neutropenia. Pediatr Radiol. 2015;45(7):1066–71. Review.
Lipton JM. Evaluation of pancytopenia. BMJ Best Practice (database). 2018. https://bestpractice.bmj.com/topics/en-us/1024. Accessed 24 Dec 2018.
McClain KL. Kaplan SL, Mahoney Jr DH, Drutz JE, editors. Peripheral lymphadenopathy in children: evaluation and diagnostic approach. Waltham: UpToDate. http://www.uptodate.com. Accessed 24 Dec 2018.
Medeiros LJ, Greiner TC. Hodgkin’s disease. Cancer. 1995;75(1 Suppl):357–69.
Nathan DG, Oski FA, Orkin SH, editors. Nathan and Oski’s hematology and oncology of infancy and childhood, vol. 2. Philadelphia: Elsevier Saunders; 2015.
Rabin KR, Whitlock JA. Malignancy in children with trisomy 21. Oncologist. 2009;14(2):164–73.
Rai KR, Stilgenbauer S, Aster JC. Larson RA, editor. Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma. Waltham: UpToDate Inc. http://www.uptodate.com. Accessed 24 Dec 2018.
Schrier SL. Mahoney Jr DH, editor. Acquired aplastic anemia in children and adolescents. Waltham: UpToDate. http://www.uptodate.com (Accessed 24 Dec 2018
Tefferi A, Barbui T. Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk-stratification, and management. Am J Hematol. 2017;92(1):94–108.
Van Etten RA. Larson RA, editor. Clinical manifestations and diagnosis of chronic myeloid leukemia. Waltham: UpToDate. http://www.uptodate.com. Accessed 24 Dec 2018
Vannucchi AM. How I treat polycythemia vera. Blood. 2014;124(22):3212–20.
Wang WC, Ware RE, Miller ST, Iyer RV, Casella JF, Minniti CP, BABY HUG Investigators, et al. Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG). Lancet. 2011;377(9778):1663–72.
Acknowledgment
The authors gratefully acknowledge the contributions of Staci Bryson, MD, and Arlynn F. Mulne, MD, Department of Pediatrics, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA, to the 1st edition of this chapter, from which some images and tables have been incorporated into this edition as well.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Sinha, A.A., Moerdler, S., Fraint, E., Tal, A., Rahmani, N.E., Morrone, K. (2020). Hematology/Oncology. In: Naga, O.I. (eds) Pediatric Board Study Guide. Springer, Cham. https://doi.org/10.1007/978-3-030-21267-4_10
Download citation
DOI: https://doi.org/10.1007/978-3-030-21267-4_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-21266-7
Online ISBN: 978-3-030-21267-4
eBook Packages: MedicineMedicine (R0)