Abstract
Patients with X-linked agammaglobulinemia (XLA) have additional risk for autoimmune disorders
Arthritis is the most common rheumatologic manifestation in boys with XLA and is reported in 15–20% of patients
Immunosuppressive therapy for arthritis worsens immunodeficiency and contributes the development of severe infections. Early diagnosis and proper treatment may help optimize clinical outcomes for these patients
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References
Verbruggen G, De Backer S, Deforce D, Demetter P, Cuvelier C, Veys E, Elewaut D. X linked agammaglobulinaemia and rheumatoid arthritis. Ann Rheum Dis. 2005;64(7):1075–8.
Hernandez-Trujillo VP, Scalchunes C, Cunningham-Rundles C, Ochs HD, Bonilla FA, Paris K, Yel L, Sullivan KE. Autoimmunity and inflammation in X-linked agammaglobulinemia. J Clin Immunol. 2014;34(6):627–32.
Fischer A, Provot J, Jais JP, Alcais A, Mahlaoui N. Autoimmune and inflammatory manifestations occur frequently in patients with primary immunodeficiencies. J Allergy Clin Immunol. 2017;140(5):1388–1393.e1388.
Arason GJ, Jorgensen GH, Ludviksson BR. Primary immunodeficiency and autoimmunity: lessons from human diseases. Scand J Immunol. 2010;71(5):317–28.
Azizi G, Ahmadi M, Abolhassani H, Yazdani R, Mohammadi H, Mirshafiey A, Rezaei N, Aghamohammadi A. Autoimmunity in primary antibody deficiencies. Int Arch Allergy Immunol. 2016;171(3–4):180–93.
Torgerson TR. Immunodeficiency diseases with rheumatic manifestations. Pediatr Clin N Am. 2012;59(2):493–507.
Todoric K, Koontz JB, Mattox D, Tarrant TK. Autoimmunity in immunodeficiency. Curr Allergy Asthma Rep. 2013;13(4):361–70.
Goyal R, Bulua AC, Nikolov NP, Schwartzberg PL, Siegel RM. Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders. Curr Opin Rheumatol. 2009;21(1):78–84.
Ringold S, Weiss PF, Beukelman T, DeWitt EM, Ilowite NT, Kimura Y, Laxer RM, Lovell DJ, Nigrovic PA, Robinson AB, Vehe RK. 2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications. Arthritis Rheum. 2013;65(10):2499–512.
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Volokha, A. (2019). Recurrent Infections and Arthritis. In: Rezaei, N. (eds) Pediatric Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-21262-9_10
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DOI: https://doi.org/10.1007/978-3-030-21262-9_10
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