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Bioactive Ceramides in Health and Disease pp 65–77Cite as

The Role of Ceramide 1-Phosphate in Inflammation, Cellular Proliferation, and Wound Healing

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1159))

Abstract

The phospho-sphingolipid, ceramide 1-phosphate (C1P), has long been implicated as a dynamic bioactive agent. Over two decades of research has begun to characterize various regulatory roles for C1P from mammalian inflammatory response and wound healing to cellular proliferation and survival. As a metabolite of the intricately balanced “sphingolipid rheostat”, C1P stands as a crucial physiological regulator of both upstream and downstream mechanisms. This chapter serves as an overview of established and implicated roles for C1P in cellular processes vital to diseases and mammalian physiology. Additionally, we discuss potential clinical roles for C1P in cancer treatment, wound therapy, and pre-disease diagnosis. While many questions remain regarding C1P metabolism and the extent of signaling factors targeted by this bioactive lipid, new technologies and methodologies show great promise to discern key targets, signaling pathways, and physiologies regulated by C1P.

The authors Melissa L. Berwick, Brittany A. Dudley and Kenneth Maus have equally contributed to this chapter.

This work was supported, in whole or in part, by the National Institutes of Health. HL125353 (CEC), HD087198 (CEC), and AI139072 (CEC).

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Abbreviations

AA:

arachidonic acid

A-SMase:

acid sphingomyelinase

BMDMs:

bone marrow-derived macrophages

C1P:

ceramide 1-phosphate

CaLB domain:

Ca2+-dependent lipid binding domain

CerK:

ceramide kinase

CERT:

ceramide transport protein

cPLA2α:

cytosolic phospholipase A2 alpha

CPTP:

C1P transport protein

COX:

cyclooxygenases

DHA:

docosahexaenoic acid

EPA:

eicosapentaenoic acid

ER:

endoplasmic reticulum

ERK1/2:

extracellularly regulated kinases 1 and 2

IL-1β:

interleukin-1 beta cytokine

LPPs:

lipid phosphate phosphatases

LTB:

leukotriene B

NF-kB:

nuclear factor kB

NSAIDs:

non-steroidal anti-inflammatory drugs

PC:

phosphatidylcholine

PCERA-1:

a synthetic C1P analog

PGE2:

prostaglandin E2

PI3-K:

phosphatidylinositol 3-kinase

PRP:

platelet-rich plasma

S1P:

sphingosine 1-phosphate

SM:

sphingomyelin

SMase:

sphingomyelinase

SphKs:

sphingosine kinases

SPT:

serine palmitoyl transferase

TGN:

trans-Golgi network

TNFα:

tumor necrosis factor alpha

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    Authors and Affiliations

    1. Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA

      Melissa L. Berwick, Brittany A. Dudley, Kenneth Maus & Charles E. Chalfant

    2. The Moffitt Cancer Center, Tampa, FL, USA

      Charles E. Chalfant

    3. Research Service, James A. Haley Veterans Hospital, Tampa, FL, USA

      Charles E. Chalfant

    Authors
    1. Melissa L. Berwick
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    2. Brittany A. Dudley
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    3. Kenneth Maus
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    4. Charles E. Chalfant
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    Correspondence to Charles E. Chalfant .

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    Editors and Affiliations

    1. Department of Biology and Biochemistry, Faculty of Science, Birzeit University, Ramallah, Palestine, State of

      Johnny Stiban

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    Berwick, M.L., Dudley, B.A., Maus, K., Chalfant, C.E. (2019). The Role of Ceramide 1-Phosphate in Inflammation, Cellular Proliferation, and Wound Healing. In: Stiban, J. (eds) Bioactive Ceramides in Health and Disease. Advances in Experimental Medicine and Biology, vol 1159. Springer, Cham. https://doi.org/10.1007/978-3-030-21162-2_5

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